Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A fuel dispensing nozzle comprises a nozzle body defining a dispensing path extending between a distal inlet and a proximal outlet and configured to dispense fuel. A fuel flow valve is disposed in the nozzle body between the distal inlet and the proximal outlet. An actuation assembly movable to open the fuel flow valve is also provided. The nozzle also includes a shut-off mechanism operatively connected to the actuation assembly. A hand lever is pivotally connected with respect to the nozzle body, the hand lever being operatively connected to the actuation assembly so as to cause opening of the fuel flow valve when the hand lever is pivoted in a valve opening direction. The hand lever has a grasping portion extending between a proximal location nearer the proximal outlet and a distal location. The nozzle according to this aspect further includes a hold open mechanism including a trigger disposed at the proximal location of the hand lever.

Abstract: A food delivery apparatus includes a domed shell that defines an interior space. A thermal storage device is secured to the shell so as to direct heat downward to food within the interior space.

Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.

Abstract: The subject matter disclosed herein provides methods for presenting glucose level data. Glucose data for a patient may be received. A current glucose level and a rate of change of the current glucose level may be determined based on the received glucose data. A first interface may be displayed on a screen of a device. The first interface may include a unitary icon. The unitary icon may display the current glucose level and a visualization of the rate of change. Related apparatus, systems, techniques, and articles are also described.

Abstract: An air turbine starter that includes a housing. The housing can circumscribe a turbine coupled that is coupled to a gear train in a gear box via a drive shaft. The gear train can couple to an output shaft via at least a carrier. The air turbine starter can include at least a first bearing assembly and a second bearing assembly to rotatably support the drive shaft and the output shaft.

Abstract: A device and system comprising a cutting torch system including a multi-fuel adapter specially adapted to convert a gasoline oxygen cutting system to a multi-fuel cutting system and methods of using the same. The invention also includes a portable system including a carrying case for use with the multi-fuel adapter.

Abstract: A system having an enclosure for containing a solution. An atomizer is in communication with an interior of the enclosure and the solution for generating an aerosolized particle mist within the interior of the enclosure. A positive pressure device is in communication with the interior of the enclosure for generating a positive pressure within the enclosure relative to an atmosphere outside of the enclosure. An ejection nozzle having a tortuous path is provided, wherein an entrance of the tortuous path is in communication with the interior of the atomizer and an exit of the tortuous path is in communication with the atmosphere outside of the enclosure.

Abstract: A rapid detection method of a target biomolecule comprising an antigenic moiety is provided. The method includes providing a source biological sample comprising the target biomolecule; contacting the source biological sample to an ion-exchange medium; eluting the captured-target biomolecule from the ion-exchange medium as an eluate, and loading the eluate to a rapid diagnostic testing device comprising an antibody. The eluate comprises a concentrated form of the biomolecule in a solution having a salt concentration greater than 150 mM. A concentration of the target biomolecule in the eluate is in a range from about 2× to 25× compared to a concentration of the biomolecule in the source biological sample. The target biomolecule binds to the antibody under the salt concentration of greater than 150 mM. A device for rapid detection of target biomolecule is also provided.

Abstract: A pitch energy module comprising one or more ultracapacitors storing electrical energy for a wind turbine emergency pitch energy event. The pitch energy module replaces at least one battery within a battery housing of a wind turbine and interfaces with the existing battery wiring harness to communicate with a control system of the wind turbine. The pitch energy module is installed without further modification to the battery housing or the battery wiring harness.

Abstract: Three-dimensional (3D) visualization of multi-layer networks include receiving data associated with a network, wherein the network includes interconnected network elements that operate at a plurality of levels that include any of network layers and encapsulations; displaying a plurality of three-dimensional icons each represent one of a plurality of network elements of the interconnected network elements; and displaying links between the plurality of three-dimensional icons each link representing one of a network layer connection and an encapsulation connection.

Abstract: A battery management system for a lawnmower that can include a first switch configured to issue a wake-up signal in response to a wake-up input, issue a battery status request signal in response to a battery status input, and issue a shut-down signal in response to a shut-down input. A first controller can be configured to, switch the second switch to an ON state to electrically connect the battery to the electrically powered device when the first controller receives the wake-up signal, cause the display to display information indicative of a status of the battery when the first controller receives the battery status request signal, and switch the second switch to an OFF state to terminate output from the battery to the electrically powered device when the first controller receives the shut-down signal.

Abstract: A fuel dispensing nozzle comprises a nozzle body defining a dispensing path extending between a distal inlet and a proximal outlet and configured to dispense fuel. A fuel flow valve is disposed in the nozzle body between the distal inlet and the proximal outlet. An actuation assembly movable to open the fuel flow valve is also provided. The nozzle also includes a shut-off mechanism operatively connected to the actuation assembly. A hand lever is pivotally connected with respect to the nozzle body, the hand lever being operatively connected to the actuation assembly so as to cause opening of the fuel flow valve when the hand lever is pivoted in a valve opening direction. The hand lever has a grasping portion extending between a proximal location nearer the proximal outlet and a distal location. The nozzle according to this aspect further includes a hold open mechanism including a trigger disposed at the proximal location of the hand lever.

Abstract: The subject matter disclosed herein provides methods for presenting glucose level data. Glucose data for a patient may be received. A current glucose level and a rate of change of the current glucose level may be determined based on the received glucose data. A first interface may be displayed on a screen of a device. The first interface may include a unitary icon. The unitary icon may display the current glucose level and a visualization of the rate of change. Related apparatus, systems, techniques, and articles are also described.

Abstract: Disclosed are systems and methods for secure and seamless set up and modification of bolus calculator parameters for a bolus calculator tool by a health care provider (HCP). In one aspect, a method for enabling HCP set up of a bolus calculator includes providing a server accessible by both an HCP and a patient; upon login by the HCP, displaying, or transmitting for display, a fillable form, the fillable form including one or more fields for entry of one or more bolus calculator parameters; receiving data from the fillable form, the data corresponding to one or more bolus calculator parameters; and upon login by the patient, transmitting data to a device associated with the patient, the transmitted data based on the received data, where the transmitted data corresponds to one or more of the bolus calculator parameters in a format suitable for entry to a bolus calculator.

Abstract: An air turbine starter that includes a housing. The housing can circumscribe a turbine coupled that is coupled to a gear train in a gear box via a drive shaft. The gear train can couple to an output shaft via at least a carrier. The air turbine starter can include at least a first bearing assembly and a second bearing assembly to rotatably support one or more of the drive shaft, the carrier, or the output shaft.

Abstract: A method of producing liquid fuel and/or chemicals from a carbonaceous material entails combusting a conditioned syngas in pulse combustion heat exchangers of a steam reformer to help convert carbonaceous material into first reactor product gas which includes carbon monoxide, hydrogen, carbon dioxide and other gases. A portion of the first reactor product gas is transferred to a hydrogen reformer into which additional conditioned syngas is added and a reaction carried out to produce an improved syngas. The improved syngas is then subject to one or more gas clean-up steps to form a new conditioned syngas. A portion of the new conditioned syngas is recycled to be used as the conditioned syngas in the pulse combustion heat exchangers and in the hydrocarbon reformer. A system for carrying out the method include, a steam reformer, a hydrocarbon reformer, first and second gas-cleanup systems, a synthesis system and an upgrading system.

Abstract: The present disclosure relates to adjusting and maintaining a position of a cutting surface used to create lines of weakness for rolled products.

Abstract: Provided is a spring drive cam for a spring drive of a circuit breaker including a disc-like shape configured for rotating around a rotation axis in the spring drive, whereby the disc-like shape comprises a radius (R) that changes depending on an angle (?) of the radius (R) relative to a base angle (?0), and whereby a rate (dR/d?) defined by a change of the radius (R) per change of the angle (?) is ?0.3 mm/°.

Abstract: Genetically engineered immune cells such as T cells having a disrupted CD83 gene and optionally expressing a chimeric antigen receptor (CAR) and therapeutic applications thereof. Such genetically engineered immune cells may further comprise a disrupted TRAC gene, a disrupted ?2M gene, or a combination thereof.