Patents by Inventor Brian Connolly
Brian Connolly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11660104Abstract: An endovascular apparatus for crossing through an obstruction in a blood vessel comprises: an elongate endovascular element such as a wire; an ultrasonic transducer, mechanically coupled to the endovascular element for ultrasonically exciting a distal tip portion thereof to facilitate the crossing through the obstruction, and one or more damping features, mechanically coupled to the endovascular element to attenuate lateral displacement of the endovascular element at positions away from the distal tip portion.Type: GrantFiled: November 6, 2020Date of Patent: May 30, 2023Assignee: Versono Medical LimitedInventors: Finbar Dolan, Hugh O'Donoghue, Ivan Mooney, Pat Connolly, Jim Smedley, Brian Tarpey
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Patent number: 11377787Abstract: The present invention is directed to dye mixtures comprising structures of formula and their production and their use for dyeing textiles and in particular for dyeing aramid fibres.Type: GrantFiled: December 7, 2017Date of Patent: July 5, 2022Assignee: DYSTAR COLOURS DISTRIBUTION GMBHInventors: Adrian Murgatroyd, Manfred Hoppe, Clemens Grund, Brian Connolly, Thomas Stepanski
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Patent number: 11370833Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.Type: GrantFiled: July 3, 2018Date of Patent: June 28, 2022Assignee: Genentech, Inc.Inventors: Lan Le, Brian Connolly
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Publication number: 20220040312Abstract: The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.Type: ApplicationFiled: January 22, 2021Publication date: February 10, 2022Applicant: Genentech, Inc.Inventors: Brian CONNOLLY, Lydia HAMBURG, Emily HOLZ
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Patent number: 10933141Abstract: The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.Type: GrantFiled: November 21, 2019Date of Patent: March 2, 2021Assignee: GENENTECH, INC.Inventors: Brian Connolly, Lydia Hamburg, Emily Holz
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Patent number: 10869597Abstract: Methods, apparatus, and systems are provided for scanning and measuring an anatomical cavity. An apparatus may include an absorbing medium assembly that is fluidly connected to an earpiece and configured to provide an absorbing medium to the earpiece. The absorbing medium assembly may include a medium container with a gas trap, as well as a tube fluidly connected to the medium container. The gas trap may be located at a top portion of the medium container. The tube may be coupled to the top portion or a bottom portion of the medium container. The system may include a dip tube disposed inside the medium container when the tube of the absorbing medium assembly couples to a top portion of the medium container. A gas relief valve configured to enable gas to escape may also be present in the apparatus.Type: GrantFiled: November 24, 2015Date of Patent: December 22, 2020Assignee: LANTOS TECHNOLOGIES, INC.Inventors: Shawn M. Patterson, Steve Schmidt, Mac Andrew Dougan, Brian Connolly, Manas Menon, Lynn Ihlenfeldt
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Publication number: 20200215195Abstract: The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.Type: ApplicationFiled: November 21, 2019Publication date: July 9, 2020Applicant: Genentech, Inc.Inventors: Brian CONNOLLY, Lydia HAMBURG, Emily HOLZ
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Patent number: 10525137Abstract: The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.Type: GrantFiled: December 28, 2016Date of Patent: January 7, 2020Assignee: Genentech, Inc.Inventors: Brian Connolly, Lydia Hamburg, Emily Holz
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Publication number: 20190338461Abstract: The present invention is directed to dye mixtures comprising structures of formula and their production and their use for dyeing textiles and in particular for dyeing aramid fibres.Type: ApplicationFiled: December 7, 2017Publication date: November 7, 2019Inventors: ADRIAN MURGATROYD, Manfred HOPPE, Clemens GRUND, Brian CONNOLLY, Thomas STEPANSKI
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Publication number: 20190161541Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.Type: ApplicationFiled: July 3, 2018Publication date: May 30, 2019Inventors: Lan LE, Brian Connolly
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Patent number: 10301475Abstract: The invention relates to mixtures of fiber-reactive Triphendioxazine dyes with other fiber-reactive azo dyes and their use for the dyeing of hydroxyl- and especially carboxamide-containing material in blue and navy shades.Type: GrantFiled: October 26, 2016Date of Patent: May 28, 2019Assignee: DryStar Colours Distribution GmbHInventors: Adrian Murgatroyd, Manfred Hoppe, Clemens Grund, Brian Connolly, Thomas Stepanski
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Publication number: 20180230311Abstract: The invention relates to mixtures of fibre-reactive Triphendioxazine dyes with other fibre-reactive azo dyes and their use for the dyeing of hydroxyl- and especially carboxamide-containing material in blue and navy shades.Type: ApplicationFiled: October 26, 2016Publication date: August 16, 2018Inventors: Adrian MURGATROYD, Manfred HOPPE, Clemens GRUND, Brian CONNOLLY, Thomas STEPANSKI
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Publication number: 20170189536Abstract: The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.Type: ApplicationFiled: December 28, 2016Publication date: July 6, 2017Inventors: Brian CONNOLLY, Lydia HAMBURG, Emily HOLZ
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Patent number: 9445619Abstract: Provided herein are exemplary compositions, products, and capsules utilizing POA, EPA, blends of POA and EPA, total algal oil compositions, and/or whole biomass compositions in methods of inhibiting inflammation including in cardiovascular disease, diabetes, obesity, stroke, metabolic syndromes, dementia, Alzheimer's disease, and/or cancer. The exemplary compositions, products, and capsules may be orally, topically, intravenously, and/or subcutaneously administered. The exemplary compositions herein may be used as feed, food, food supplements, beverages, beverage supplements, nutritional products, products for athletic performance, pharmaceutical products, and/or medical products for mammalian use, including humans.Type: GrantFiled: September 12, 2013Date of Patent: September 20, 2016Assignee: AURORA ALGAE, INC.Inventors: James Astwood, Michelle L. Collins, Brian Connolly
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Publication number: 20160150949Abstract: Methods, apparatus, and systems are provided for scanning and measuring an anatomical cavity. An apparatus may include an absorbing medium assembly that is fluidly connected to an earpiece and configured to provide an absorbing medium to the earpiece. The absorbing medium assembly may include a medium container with a gas trap, as well as a tube fluidly connected to the medium container. The gas trap may be located at a top portion of the medium container. The tube may be coupled to the top portion or a bottom portion of the medium container. The system may include a dip tube disposed inside the medium container when the tube of the absorbing medium assembly couples to a top portion of the medium container. A gas relief valve configured to enable gas to escape may also be present in the apparatus.Type: ApplicationFiled: November 24, 2015Publication date: June 2, 2016Inventors: Shawn M. Patterson, Steve Schmidt, Mac Andrew Dougan, Brian Connolly, Manas Menon, Lynn Ihlenfeldt
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Publication number: 20160137727Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.Type: ApplicationFiled: September 15, 2015Publication date: May 19, 2016Inventors: Lan LE, Brian CONNOLLY
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Patent number: 8868613Abstract: Systems and methods, including computer software products, for updating data on a remote device involve defining multiple channels on a remote device, where each channel is associated with a predetermined type of content. Content updates for the channels are automatically delivered to the remote device, and an update frequency is identified for each channel. A most frequent update frequency among the multiple channels defined on the remote device is determined, and updates to the channels are requested according to the most frequent update frequency.Type: GrantFiled: November 26, 2007Date of Patent: October 21, 2014Assignee: Adobe Systems IncorporatedInventors: Antti Piira, Rupen Chanda, Brian Connolly
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Publication number: 20140271706Abstract: Provided herein are exemplary compositions, products, and capsules utilizing POA, EPA, blends of POA and EPA, total algal oil compositions, and/or whole biomass compositions in methods of inhibiting inflammation including in cardiovascular disease, diabetes, obesity, stroke, metabolic syndromes, dementia, Alzheimer's disease, and/or cancer. The exemplary compositions, products, and capsules may be orally, topically, intravenously, and/or subcutaneously administered. The exemplary compositions herein may be used as feed, food, food supplements, beverages, beverage supplements, nutritional products, products for athletic performance, pharmaceutical products, and/or medical products for mammalian use, including humans.Type: ApplicationFiled: September 12, 2013Publication date: September 18, 2014Applicant: Aurora Algae, Inc.Inventors: James Astwood, Michelle L. Collins, Brian Connolly
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Patent number: 8214619Abstract: Systems and methods, including computer software stored on a machine-readable medium for performing operations, can be implemented for allocating memory. Multiple channels are defined on a mobile device. Each channel can be adapted to receive a predetermined type of content for access on the mobile device. An amount of memory allocated to each channel for storing data is defined. Data identifying a new amount of memory allocated to one of the channels is received, and the amount of memory allocated to the channel is adjusted based on the data identifying the new amount of memory.Type: GrantFiled: November 26, 2007Date of Patent: July 3, 2012Assignee: Adobe Systems IncorporatedInventors: Brian Connolly, Rupen Chanda
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Publication number: 20120046203Abstract: The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes.Type: ApplicationFiled: September 24, 2009Publication date: February 23, 2012Applicant: Straus Holdings Inc.Inventors: Bruce Walsh, Boris Blanter, Matthew Barra, Brian Connolly, Greg Yantz, Paul Gervasio, Don Straus