Abstract: The present technology generally relates to implantable medical devices and, in particular, to systems and methods for selectively adjusting implantable shunting systems, including fully closing the shunting systems after implantation within a patient. For example, many embodiments of the present technology are directed to systems and method for plugging or sealing a lumen in an adjustable shunting element configured to fluidly couple a first body region and a second body region. At least some embodiments of the systems and methods for selectively closing interatrial shunting systems include closure devices configured to be removable, such that the closure device can be removably coupled to the implantable shunting system to at least partially or fully prevent fluid flow therethrough for a time, and can be removed from the implantable shunting system to allow fluid flow through the implantable shunting system to resume.

Abstract: The present technology provides adjustable shunting systems with actuation assemblies that can be selectively adjusted to change a level of therapy provided by the shunt. The actuation assemblies can include a shape memory actuator having a plurality of leaflets or projections forming a conical shape with openings on both ends of the cone. The actuation assemblies can further include one or more membranes that individually jacket or cover individual projections of the plurality of projections to form a lumen extending through the conical shape.

Abstract: In an example, a method for delivery of a therapeutic agent to at least one of a palatine canal or a pterygopalatine fossa of a patient is described. The method includes inserting a delivery device into a nasal cavity of a patient. The delivery device includes an elongated shaft with a proximal end and a distal end, a handpiece coupled to the proximal end of the elongated shaft, and a boring element disposed on the distal end of the elongated shaft. The method also includes advancing the distal end of the elongated shaft to a position proximate to a palatine bone within the nasal cavity, actuating the boring element to form a passage in the palatine bone between the nasal cavity and a palatine canal of the patient, and delivering a therapeutic agent into the palatine canal.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: The present technology is directed to implantable medical devices comprising an electrical circuit for powering one or more active components of the device, such as an actuation element, an engine, or a sensor. The electrical circuit can include one or more inductors having a plurality of receiving coils that generate a current in response to being exposed to an electromagnetic field. The current generated by the receiving coils can be used to directly or indirectly power the one or more active components. The inductors can have one or more wires having a non-concentric configuration such that, in addition to generating the current for powering the device, the receiving coils also anchor a portion of the device when it is implanted. For example, the receiving coils can be at least partially composed of a superelastic material such that they exhibit superelastic properties at body temperature.

Abstract: The present technology is directed to implantable medical systems that can include a first implantable device, a second implantable device, and a communication assembly that extends between and physically couples the first device and the second device. The first device can include one or more first electronic components, and the second device can include one or more second electronic components. The communication assembly can include (a) one or more first wires that are configured to wirelessly receive data from, and/or wirelessly transmit data to, a third device positioned external to the patient, and (b) one or more second wires that are configured to conductively transfer power between the first electronic components and the second electronic components. In some embodiments, the one or more first wires have a helical configuration, and the one or more second wires have a linear configuration and extend within the one or more first wires.

Abstract: The present technology relates to interatrial shunting systems and methods. In some embodiments, the present technology includes a system for shunting blood between a left atrium and a right atrium of a patient. The system can include a shunting element having a lumen extending therethrough. The lumen is configured to fluidly couple the left atrium and the right atrium when the shunting element is implanted in the patient. The system can also include a sensor configured to be implanted in the patient and operably coupled to the shunting element. An actuation element is coupled to the sensor. The actuation element is configured to be selectively energized and transmit a desired motion to the sensor to reduce the likelihood of tissue ingrowth/overgrowth and adhesion on at least a portion of the sensor.

Abstract: Closure devices that selectively control blood flow between the right atrium and the left atrium of a heart of a patient. The control of blood flow can be based on detected values from a pressure sensor. The closure devices can include a body configured to engage native tissue when the device is deployed across the septal wall. In a first state at least a portion of (an inner surface of) a lumen is closed, preventing blood flow through the closure device. In a second state, the lumen is open to enable blood flow from the left atrium to the right atrium. A closure element can be selectively adjusted to control the flow of blood through the lumen. A volume of an expandable chamber can be increased or decreased to place the closure device into the first state or the second state.

Abstract: The present technology includes systems and methods for invasively adjusting implantable devices for selectively controlling fluid flow between a first body region and a second body region of a patient. For example, in many of the embodiments described herein, a catheter can be used to mechanically and/or electrically engage an implanted medical device. Once the catheter engages the medical device, the catheter can (i) increase a dimension associated with the medical device, such as through mechanical expansion forces, and/or (ii) decrease a dimension associated with the medical device, such as by heating a shape memory component of the medical device above a phase transition temperature.

Abstract: The present technology relates to intracardiac pressure monitoring devices, and associated systems and methods. In some embodiments, the present technology includes a device for monitoring pressure within a patient's heart. The device can include a pressure sensor configured to reside within a first chamber of a heart of a patient, and a pressure transmission element configured to extend from the first chamber through a septal wall to a second chamber of the heart of the patient. When the device is implanted in the patient's heart, the pressure transmission element is configured to transmit pressure from the second chamber to the pressure sensor residing within the first chamber.

Abstract: The present technology relates to shunting systems and methods. In some embodiments, the present technology includes a method for monitoring a shunting element implanted in a patient and having a lumen fluidly coupling two body regions. The method can comprise applying an electrical input to a first contact region and a second contact region of the shunting element. The method can also include measuring an electrical output that results from the electrical input. The method can further include calculating, via the processor, an electrical parameter associated with the shunting element based, at least in part, on the electrical output. The electrical parameter can vary based on a size of the lumen of the shunting element. The method can determine, via the processor, the size of a portion of the lumen based, at least in part, on the electrical parameter.

Abstract: The present technology is generally directed to interatrial shunting systems and associated devices and methods. For example, a system configured in accordance with embodiments of the present technology can include a shunting element implantable into a patient at or adjacent a septal wall. The shunting element can have a lumen that fluidly connects a left atrium and a right atrium of the patient to facilitate blood flow therebetween when the shunting element is implanted. In some embodiments, the system further includes a flow control element to selectively control blood flow between the left atrium and the right atrium.

Abstract: In an example, a cryotherapy device includes an elongated shaft, and a cryotherapy delivery member coupled to a distal end of the elongated shaft. The cryotherapy delivery member is configured to apply, from a fixed position in a nasal cavity, thermal energy to at least one of a plurality of nerves in the nasal cavity or a plurality of branches of a nerve in the nasal cavity.

Abstract: The present technology is generally directed to implantable medical devices and associated methods. For example, a system configured in accordance with embodiments of the present technology can include a body implantable into a patient and configured to undergo a shape change, the body having a conductive path with variable conductivity in portions thereof for selective and/or preferential heating. The body can be coupled with an energy source that can delivery energy to the body and/or conductive path, to promote the shape change in the body.

Abstract: The present technology relates to power management for interatrial shunting systems. In some embodiments, the present technology includes a system for shunting blood between a left atrium and a right atrium of a patient. The system can include a shunting element and a plurality of active electronic components operably coupled to the shunting element. At least some of the active electronic components have different power consumption characteristics. The system also includes a plurality of energy storage components, with some of the energy storage components have different characteristics. During operation, the system is configured to receive a signal indicating that an active electronic component is to be operated, and select an energy storage component associated with power output characteristics capable of accommodating the power consumption characteristics of the active electronic component.

Abstract: In an example, a cryotherapy device includes an elongated shaft, and a cryotherapy delivery member coupled to a distal end of the elongated shaft. The cryotherapy delivery member is configured to apply, from a fixed position in a nasal cavity, thermal energy to at least one of a plurality of nerves in the nasal cavity or a plurality of branches of a nerve in the nasal cavity.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: Systems, devices, and methods involve ablation of tissue to treat rhinitis and/or other nasal conditions. Implementations allow treatment of tissue in the confined space of the nasal cavity. Additionally, implementations allow targeted treatment tissue to be ablated, while protecting other non-treatment tissue from unintentional collateral effects that might be produced by the ablation. According to an example implementation, an approach for treating a nasal condition includes advancing a probe into a nasal cavity, the probe including a shaft and a cryotherapy element coupled to the shaft. The approach also includes cryogenically cooling a target treatment site with the cryotherapy element to treat at least one nasal nerve. Additionally, the approach includes transmitting a focused ultrasound beam to a target heating site to increase a temperature tissue at the target heating site.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: The present technology generally relates to a sensor assembly for an implantable medical device. In some embodiments, the sensor assembly includes a housing having a cavity, and a measurement component positioned within the cavity. When the medical device is implanted within a patient, the sensor can be configured to measure one or more physiological parameters of the patient. In some embodiments, the sensor assembly further includes a coupling element positioned within the cavity and at least partially covering, contacting, or encapsulating the measurement component. The coupling element can be configured to transmit or convey the one or more physiological parameters to the measurement component, such that the measurement component can measure the one or more physiological parameters without exposure to an environment external to the sensor assembly.