Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: A system and method for a hybrid multimode input device includes a multimode input device capable of a two-dimensional (2D) mode of operation and a three-dimensional (3D) mode of operation. The device includes a two-dimensional (2D) position sensor, a three-dimensional (3D) position sensor, and a processor. The processor is configured to enter a 3D input mode when the processor detects that the input device is in a first orientation, and enter a 2D input mode when the processor detects that the input device is in a second orientation. The 2D input mode is configured to provide 2D position data to a connected computer system, and wherein the 3D input mode is configured to provide 3D position data to the connected computer system.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: The present disclosure includes methods and devices for generation and control of virtual displays in a virtual environment. A method includes receiving a trigger input from a user of a computing device, the computing device including a physical display that displays first content, initiating at least one virtual display based on the trigger input from the user, providing the at least one virtual display in association with the physical display, and displaying second content via the at least one virtual display in association with the first content displayed via the physical display.

Abstract: A milling cutter includes a milling drum having a body with a first end, a second end, an outer surface extending around a circumference of the body between the first and second ends, and a plurality of slots formed in the outer surface. The plurality of slots arranged in a staggered row between the first end and the second end of the body. The milling cutter also includes a plurality of cutting insert removably secured to the body. Each cutting insert is positioned at least partially within one of the plurality of slots and includes a cutting profile defined by rounded peaks and pointed valleys to cut a tooth form into a saw blade. The plurality of cutting inserts are staggered such that the plurality of cutting inserts are circumferentially offset from each other along a longitudinal axis of the milling drum.

Abstract: In one embodiment, a computing system may access one or more frames of media content with each frame corresponding to at least part of an image. The computing system may automatically detect at least one object in at least one of the one or more frames. The computing system may automatically identify the at least one object. For each of the identified objects, the computing system may automatically determine an annotation corresponding to that object and each annotation may include one or more graphical elements. For each annotation, the computing system may automatically associate that annotation for display with its corresponding object.

Abstract: An apparatus for a robotic limb includes one or more limb segments connected via one or more joints. The robotic limb may feature one or more dual-reduction quasi-quasi-direct-drive joint actuators that permit the robotic limb to move throughout a scene. The robotic limb may further include an end-effector connected to a free end of the robotic limb with one or more opposable fingers comprising a four bar linkage. The end-effector may include a main actuator that actuates the one or more fingers via the four-bar linkages to complete various tasks.

Abstract: A method of manufacturing a saw blade includes providing a saw blade body, forming a plurality of gullets and a first portion of a plurality of tooth bodies in the saw blade body with each gullet positioned between adjacent tooth bodies, and forming a second portion of the plurality of tooth bodies in the saw blade body separate to forming the plurality of gullets and the first portion of the plurality of tooth bodies in the saw blade body.

Abstract: A system and method for a hybrid multimode input device includes a multimode input device capable of a two-dimensional (2D) mode of operation and a three-dimensional (3D) mode of operation. The device includes a two-dimensional (2D) position sensor, a three-dimensional (3D) position sensor, and a processor. The processor is configured to enter a 3D input mode when the processor detects that the input device is in a first orientation, and enter a 2D input mode when the processor detects that the input device is in a second orientation. The 2D input mode is configured to provide 2D position data to a connected computer system, and wherein the 3D input mode is configured to provide 3D position data to the connected computer system.

Abstract: The present disclosure includes methods and devices for generation and control of virtual displays in a virtual environment. A method includes receiving a trigger input from a user of a computing device, the computing device including a physical display that displays first content, initiating at least one virtual display based on the trigger input from the user, providing the at least one virtual display in association with the physical display, and displaying second content via the at least one virtual display in association with the first content displayed via the physical display.

Abstract: An apparatus and method for a wall clock AI voice assistant, such as a computing device, is provided herein. The wall-mountable electronic clock includes an optical sensor, a microphone, a digital display and a speaker. The optical sensor captures image data representing at least a portion of a user. The microphone receives an audio input from the user when certain criteria is met, such as when the image data representing at least a portion of the user is captured. The digital display provides visual information to the user provided in response to the captured image data or the audio input. The speaker provides audio information provides from a digital voice assistant in response to the captured image data or the audio input.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: In one embodiment, one or more systems may receive input from a user identifying an interactive region of a physical environment. The one or more systems may determine a location of the interactive region relative to a depth sensor and monitor, at least in part by the depth sensor, the interactive region for a predetermined event. The one or more systems may detect, at least in part by the depth sensor, the predetermined event. In response to detecting the predetermined event, the one or more systems may initiate a predetermined action associated with the predetermined event.

Abstract: In one embodiment, a computing system may access one or more frames of media content with each frame corresponding to at least part of an image. The computing system may automatically detect at least one object in at least one of the one or more frames. The computing system may automatically identify the at least one object. For each of the identified objects, the computing system may automatically determine an annotation corresponding to that object and each annotation may include one or more graphical elements. For each annotation, the computing system may automatically associate that annotation for display with its corresponding object.

Abstract: In one embodiment, one or more systems may receive input from a user identifying an interactive region of a physical environment. The one or more systems may determine a location of the interactive region relative to a depth sensor and monitor, at least in part by the depth sensor, the interactive region for a predetermined event. The one or more systems may detect, at least in part by the depth sensor, the predetermined event. In response to detecting the predetermined event, the one or more systems may initiate a predetermined action associated with the predetermined event.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: In one embodiment, one or more systems may receive input from a user identifying an interactive region of a physical environment. The one or more systems may determine a location of the interactive region relative to a depth sensor and monitor, at least in part by the depth sensor, the interactive region for a predetermined event. The one or more systems may detect, at least in part by the depth sensor, the predetermined event. In response to detecting the predetermined event, the one or more systems may initiate a predetermined action associated with the predetermined event.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: A milling cutter includes a milling drum having a body with a first end, a second end, an outer surface extending around a circumference of the body between the first and second ends, and a slot formed in the outer surface. The milling cutter also includes a cutting insert positioned at least partially within the slot and removably secured to the body. The cutting insert includes a cutting profile defined by rounded peaks and pointed valleys to cut a tooth form into a saw blade.