Abstract: A method for selecting a combination of therapeutic agents can include: providing a response surface having data that relates network activation states of a downstream component of a biological network with activation states of at least two upstream components of the network; identifying a desired network activation state of the downstream component from the response surface; identifying the corresponding activation states of the upstream components and identifying at least two therapeutic agents that modulate the upstream components and that are capable of obtaining the desired network activation state. The response surface can be visual or virtual. Optionally, the desired network activation state is an optimal network activation state.

Abstract: The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.

Abstract: A system and method for narrowing the range of frequency uncertainty of a Doppler shifted pilot signal in a satellite or other communications system with relative signal source and receiver motion. The satellite communications system includes a user terminal (for example, a mobile wireless telephone), a gateway (terrestrial base station), and at least one satellite with unknown position and unknown relative velocity. The method includes the steps of shifting the pilot signal over a plurality of frequency hypotheses, coherently accumulating samples of the pilot signal over a plurality of chips, measuring the energy of the accumulated pilot signal samples, accumulating the energy measurements over a plurality of chips to produce an energy accumulation value, and determining which of the plurality of frequency hypotheses results in the highest energy accumulation value.

Abstract: A technique for spreading information signals in a spread spectrum communication system to provide increased signal acquisition speed. A first PN spreading code or code set is used to spread information signals along with a second PN spreading code sequence or function. The second PN code is synchronized with the first PN spreading code, but has a larger code period so that each code chip of the second PN code extends over the entire period of the first PN code. The longer period spreading code forms an outer code which helps provide unambiguous beam identification and easily acquired frame timing in the presence of dynamically changing signal path delay, improving signal acquisition.

Abstract: A system and method for narrowing the range of frequency uncertainty of a Doppler shifted pilot signal in a satellite or other communications system with relative signal source and receiver motion. The satellite communications system includes a user terminal (for example, a mobile wireless telephone), a gateway (terrestrial base station), and at least one satellite with unknown position and unknown relative velocity. The method includes the steps of shifting the pilot signal over a plurality of frequency hypotheses, coherently accumulating samples of the pilot signal over a plurality of chips, measuring the energy of the accumulated pilot signal samples, accumulating the energy measurements over a plurality of chips to produce an energy accumulation value, and determining which of the plurality of frequency hypotheses results in the highest energy accumulation value.

Abstract: A system and method for narrowing the range of frequency uncertainty of a Doppler shifted pilot signal in a satellite or other communications system with relative signal source and receiver motion. The satellite communications system includes a user terminal (for example, a mobile wireless telephone), a gateway (terrestrial base station), and at least one satellite with unknown position and unknown relative velocity. The method includes the steps of shifting the pilot signal over a plurality of frequency hypotheses, coherently accumulating samples of the pilot signal over a plurality of chips, measuring the energy of the accumulated pilot signal samples, accumulating the energy measurements over a plurality of chips to produce an energy accumulation value, and determining which of the plurality of frequency hypotheses results in the highest energy accumulation value.

Abstract: A technique for using energy received by subscriber units over multiple orthogonal channels within a spread spectrum communication system to acquire signal timing by controlling signal amplitude integration intervals used in detecting such timing. Received signals are despread and respective amplitudes integrated over periods that are divisible by factors of 2 into the length of Walsh functions used to generate orthogonal signal channels. Non-coherent combinations of the results of this integration are subsequently formed over periods that commence and terminate on Walsh function boundaries, and used to determine when a correct time offset has been selected for despreading signals. Additional advantages are realized by assigning signals that consistently provide a higher energy content such as paging, synchronization, and most frequently assigned traffic channels to specific orthogonal channels within the communication system.