Abstract: The present disclosure provides antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1). The disclosure also provides, enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection. Also disclosed are pharmaceutical compositions and their use.

Abstract: The present invention relates to novel therapeutic agents against hepatitis B virus (HBV) infection, particularly inhibitors of viral covalently closed circular DNA (cccDNA) which is the key barrier for HBV cure. Accordingly, the invention provides the pyrrolo[2,3-b]pyrazine compounds of formula (I), as described and defined herein, for use in the treatment of HBV infection. The compounds provided herein are highly potent against HBV infection and enable an improved therapy, particularly of chronic HBV infection and HBV rebound. The present invention further relates to a novel screening assay for the identification of therapeutic agents against HBV infection, particularly cccDNA inhibitors, which is performed in hepatocyte-like cells that recapitulate the complete HBV life cycle following infection with patient-derived HBV.

Abstract: In one aspect, a smart watch or other device may include at least one processor, a display accessible to the at least one processor, and storage accessible to the at least one processor. The storage may include instructions executable by the at least one processor to identify an orientation of a user’s head and identify an orientation of the smart watch with respect to the user’s head. The instructions may also be executable to, based on the orientation of the user’s head and the orientation of the smart watch, present content on the display in a content orientation that is maintained with respect to a reference for the content to appear upright on the display relative to the reference.

Abstract: Embodiments described herein relate to methods for preparing catalysts and catalyst supports. In one embodiment, transition metal carbide materials, having a nanotube like morphology, are utilized as a support for a precious metal catalyst, such as platinum. Embodiments described herein also relate to proton exchange membrane fuel cells that incorporate the catalysts described herein.

Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.

Abstract: A novel ledge forming system used to attach a polymer retention hub to a thin wall nozzle core to provide an efficient way to produce a conjunct nozzle. The inventive apparatus provides a means for assembly of components by a method involving use of a press with a heating element to elevate temperature of a thermoplastic polymer to permit formation of a ledge that overhangs the flange of a nozzle core, mechanically locking components together. Execution of the process is rapid, low cost and eliminates damage to the thin wall of the core that would occur if the polymer retention hub were molded around the nozzle core.

Abstract: The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.

Abstract: Embodiments described herein relate to methods for preparing catalysts and catalyst supports. In one embodiment, transition metal carbide materials, having a nanotube like morphology, are utilized as a support for a precious metal catalyst, such as platinum. Embodiments described herein also relate to proton exchange membrane fuel cells that incorporate the catalysts described herein.

Abstract: This invention relates to an insert component to be affixed to a panel. The insert component comprises a body, the body including a first face and a second face, the body defining at least one opening extending between the first face and the second face, said at least one opening positioned within a perimeter of the body. A flange portion extends substantially radially outwardly from one or each of said at least one opening. At least one rim is provided upon said first face and substantially about a perimeter of each said opening. At least one channel region is provided in said first face and substantially about the perimeter of each said opening, said channel region located outwardly of said rim relative to said perimeter of each said opening.

Abstract: Embodiments described herein relate to methods for preparing catalysts and catalyst supports. In one embodiment, transition metal carbide materials, having a nanotube like morphology, are utilized as a support for a precious metal catalyst, such as platinum. Embodiments described herein also relate to proton exchange membrane fuel cells that incorporate the catalysts described herein.

Abstract: A novel ledge forming system used to attach a polymer retention hub to a thin wall nozzle core to provide an efficient way to produce a conjunct nozzle. The inventive apparatus provides a means for assembly of components by a method involving use of a press with a heating element to elevate temperature of a thermoplastic polymer to permit formation of a ledge that overhangs the flange of a nozzle core, mechanically locking components together. Execution of the process is rapid, low cost and eliminates damage to the thin wall of the core that would occur if the polymer retention hub were molded around the nozzle core.

Abstract: An insert body used in an existing aperture within a building panel, the body defining an aperture with geometry varied relative to the existing aperture, and comprising an inner surface, an outer surface, a front face and a rear face. The inner surface provides an inner side wall of the aperture to be formed, the outer surface provides for an outer side wall of the aperture to be formed and/or of the existing aperture to be varied. The outer side wall in use is located adjacent to the existing aperture side wall. The rear face provides a support surface for location upon the second face of the panel. The inner side wall terminates in at least one rim on the front face. The front face comprises at least one recessed region and each rim having a surface projected from the recessed region as a reference relative to the first face.

Abstract: A novel design of a polymer retention hub created having an innovative feature used to permanently attach a thin wall nozzle core without use of adhesives or ancillary parts to form a conjunct nozzle. Additional polymer in the correct amount is molded into a polymer retention hub in close proximity to a location where a mechanical lock must be formed to join the two components together. The inventive design of the polymer retention hub is configured to produce an enclosed cavity with the strength required for separation of a nozzle core from a standard taper.

Abstract: Embodiments described herein relate to methods for preparing catalysts and catalyst supports. In one embodiment, transition metal carbide materials, having a nanotube like morphology, are utilized as a support for a precious metal catalyst, such as platinum. Embodiments described herein also relate to proton exchange membrane fuel cells that incorporate the catalysts described herein.

Abstract: Disclosed herein is a solid feed formulation for feeding to livestock. The formulation comprises comminuted saltbush or bluebush plant material as a protein component. Optionally, the formulation further comprises an energy component, such as feed barley, a vegetable oil, plant material from plants of the genus Artemisia, and/or one or more excipients or additives.