Abstract: A method for correcting long-term phase drift of a crystal oscillator in a numerically-controlled oscillator is described. The method includes determining the phase error in an oscillator signal in comparison with an external time base; delta-sigma modulating the phase error to generate a delta-sigma error bitstream; conditionally adding or subtracting an error correction step size from a phase increment value in each clock cycle based on the delta-sigma error bitstream, to create a modulated phase increment value; and adding the modulated phase increment value to a phase accumulator to generate an error-corrected output digital signal. The delta-sigma-based error correction method avoids the use of multipliers. The same delta-sigma error signal can be used in multiple numerically-controlled oscillators configured to different output frequency if driven by the same reference oscillator.

Abstract: Described is a method and devices to determine root-mean-square of a delta-sigma modulated signal. The method includes filtering the delta-sigma modulated signal to produce a multi-bit filtered signal, delaying a copy of the delta-sigma modulated signal by a fixed number of samples to align with the filtered input, setting a sign of each multi-bit value of the multi-bit filtered signal based upon a corresponding sample value of the delayed copy of the delta-sigma modulated signal, to generate a hybrid signal, summing the hybrid signal to produce a summed signal, and determining the average of the summed signal and the square root of the average to produce a root-mean-square value.

Abstract: The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.

Abstract: An insert body used in an existing aperture within a building panel, the body defining an aperture with geometry varied relative to the existing aperture, and comprising an inner surface, an outer surface, a front face and a rear face. The inner surface provides an inner side wall of the aperture to be formed, the outer surface provides for an outer side wall of the aperture to be formed and/or of the existing aperture to be varied. The outer side wall in use is located adjacent to the existing aperture side wall. The rear face provides a support surface for location upon the second face of the panel. The inner side wall terminates in at least one rim on the front face. The front face comprises at least one recessed region and each rim having a surface projected from the recessed region as a reference relative to the first face.

Abstract: A method for correcting long-term phase drift of a crystal oscillator in a numerically-controlled oscillator is described. The method includes determining the phase error in an oscillator signal in comparison with an external time base; delta-sigma modulating the phase error to generate a delta-sigma error bitstream; conditionally adding or subtracting an error correction step size from a phase increment value in each clock cycle based on the delta-sigma error bitstream, to create a modulated phase increment value; and adding the modulated phase increment value to a phase accumulator to generate an error-corrected output digital signal. The delta-sigma-based error correction method avoids the use of multipliers. The same delta-sigma error signal can be used in multiple numerically-controlled oscillators configured to different output frequency if driven by the same reference oscillator.

Abstract: The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.

Abstract: The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.

Abstract: The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.

Abstract: Described is a method and devices to determine root-mean-square of a delta- sigma modulated signal. The method includes filtering the delta-sigma modulated signal to produce a multi-bit filtered signal, delaying a copy of the delta-sigma modulated signal by a fixed number of samples to align with the filtered input, setting a sign of each multi-bit value of the multi-bit filtered signal based upon a corresponding sample value of the delayed copy of the delta-sigma modulated signal, to generate a hybrid signal, summing the hybrid signal to produce a summed signal, and determining the average of the summed signal and the square root of the average to produce a root-mean-square value.

Abstract: The present invention provides an automotive headlamp assembly having a light pipe. The present invention provides use of at least one incandescent light bulb to illuminate the light pipe. Power consumption is reduced from approximately 35 watts to 10 watts. The present assembly consists of a light pipe, at least one light source positioned at either end of the light pipe, the light source being an incandescent light bulb, at least one reflector and an elongated reflector positioned adjacent the light pipe. The reflector is positioned adjacent the light source to capture light from the light bulb, concentrate the light into a beam and reflect the light into the light pipe. The reflector aims light directly down the light pipe without the use of cable or LED mounted to the light pipe. The reflector prevents lost light and creates a more efficient headlamp assembly. The light pipe is a generally cylindrical elongated member having a plurality of attachment members.

Abstract: The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.

Abstract: The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.

Abstract: The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.

Abstract: A novel design and method of attachment of a retention device to a monolithic thin walled deep drawn core provides an efficient system to produce a complete conjunct nozzle assembly. The design of the molded retention device contains the provision for joining the parts together without the use of adhesives or ancillary parts. Additional polymer in the correct amount is molded into the retention device in close proximity to the location where a mechanical lock must be formed to join the two components together. An inventive tool enables the technique for shut off of the monolithic core from the heated thermoplastic polymer allowing formation of a ledge that overhangs the flange of the core. Execution of the process is rapid, low cost and it eliminates damage to the thin wall of the core that would occur if the retention device were molded around the core.

Abstract: A pump cartridge which has a polymer shell with moveable cores inserted from each end. The polymer shell contains perpendicular passages along the top for connection of fluid supply and prime chambers. Statically mounted elastomers adjacent to perpendicular passages provide sealing around movable cores. Fluid moves by translation within the pump cartridge by filling the cavity volume between the oblate ends of the moveable cores with a liquid and matching the rotation angle and translation position of advancing left moveable core with retreating right moveable core, maintaining equivalent volume. Both moveable cores can be directed toward one another or one moveable core can remain stationary while the other advances to extrude fluid. Pump cartridge rotation changes the angle of the fluid exit passage.

Abstract: An injection molded foam article including a structure and a projection projecting from the structure. The thickness of the projection is greater than 40% of the thickness of the structure and the front surface of the structure opposite the projection is free of sink marks.

Abstract: The present invention provides a headlamp assembly including a light pipe and reflex reflector integration utilizing a single bulb to illuminate both the reflex reflector and the light pipe, simultaneously. The headlamp assembly includes a single light source, a light pipe and a reflex reflector positioned adjacent one another allowing the light source to provide light to both the reflex reflector and the light pipe. The reflex reflector includes a reflecting element and a cutout to allow light to pass though the reflex reflector into the reflecting element. The reflex reflector is adapted to transform light from white to amber thereby creating the side marker function. The headlamp assembly further includes a reflector behind the light source to direct light into the light pipe. The automotive headlamp assembly provides an automotive headlamp assembly that includes a reflex reflector light and a light pipe while reducing cost and decreasing weight.

Abstract: The present invention provides an automotive headlamp assembly having a light pipe. The present invention provides use of at least one incandescent light bulb to illuminate the light pipe. Power consumption is reduced from approximately 35 watts to 10 watts. The present assembly consists of a light pipe, at least one light source positioned at either end of the light pipe, the light source being an incandescent light bulb, at least one reflector and an elongated reflector positioned adjacent the light pipe. The reflector is positioned adjacent the light source to capture light from the light bulb, concentrate the light into a beam and reflect the light into the light pipe. The reflector aims light directly down the light pipe without the use of cable or LED mounted to the light pipe. The reflector prevents lost light and creates a more efficient headlamp assembly. The light pipe is a generally cylindrical elongated member having a plurality of attachment members.

Abstract: A novel method of designing a twisting translational pump cartridge by utilizing a polymer shell with moveable cores inserted from each end. The polymer shell contains two perpendicular passages along the top for connection of a prime fluid chamber, a bulk fluid supply chamber and a fluid reservoir. These perpendicular passages and corresponding connection details are arranged in a fashion that is perpendicular to the axis of the polymer shell that comprises the pump cartridge cavity. Directly below at a different relative position also perpendicular to the axis of the pump cartridge cavity is an exit perpendicular passage for extrusion of fluid. The pump cartridge contains no valves or ancillary passages to direct flow between the different machine states of prime, refill, translate and dispense. The states are activated by changing the pitch of the twist or speed to determine relative position of the moveable cores with respect to each passage.

Abstract: An injection molded foam article including a structure and a projection projecting from the structure. The thickness of the projection is greater than 40% of the thickness of the structure and the front surface of the structure opposite the projection is free of sink marks.