Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: A method and system for thermal spraying braze alloy materials onto a nickel-based component to facilitate a high density brazed joint with low discontinuities is disclosed. The method and system utilize a high melt braze alloy material and a low melt braze alloy material. A thermal spraying application sprays the high melt braze alloy material and the low melt braze alloy onto a surface of a nickel-based component containing a damaged portion. The sprayed high melt braze alloy material and the low melt braze alloy form a solidified deposit within the damaged portion of the nickel-based component. The solidified deposit is a homogeneous braze coating containing the high melt braze alloy and the low melt braze alloy. The homogeneous braze coating facilitates a high density brazed joint with low discontinuities in the damaged portion of the nickel-based component.

Abstract: A system for creating a braze joint within a component. The system includes an environment operable to reach a braze temperature sufficient to melt at least a portion of a braze material. The system also includes a component within the environment, the component including a base having a base surface, a recess depending from the base surface into the base to an inner edge, and a braze material within the recess and forming a cap above the base surface. The braze material fills the recess from the cap to the inner edge. The cap has an exposed braze surface. The system also includes an insulation layer that at least partially covers the exposed braze surface.

Abstract: A system for creating a braze joint within a component. The system includes an environment operable to reach a braze temperature sufficient to melt at least a portion of a braze material. The system also includes a component within the environment, the component including a base having a base surface, a recess depending from the base surface into the base to an inner edge, and a braze material within the recess and forming a cap above the base surface. The braze material fills the recess from the cap to the inner edge. The cap has an exposed braze surface. The system also includes an insulation layer that at least partially covers the exposed braze surface.

Abstract: A method of repairing a superalloy component includes subjecting the superalloy component, including a repair area, to a phase agglomeration cycle, which includes stepped heating and controlled cooling of the component. The method further includes applying weld material to the repair area to create a weld surface; and covering the weld surface with brazing material. The component is then subjected to a braze cycle to produce a brazed component. The brazed component is cleaned, and the cleaned component is subjected to a restorative heat treatment to restore the microcrystalline structure and mechanical properties of the component.

Abstract: A method of brazing a treatment area of a load-bearing component includes applying a repair material over the treatment area of the component and positioning an induction brazing coil having a geometry corresponding to the treatment area over the repair material and the treatment area. The method further includes heating the repair material utilizing the induction brazing coil to a temperature sufficient to cause at least partial melting of the repair material, thereby effecting a brazed joint between the treatment area and the repair material.

Abstract: A system for creating a braze joint within a component. The system includes an environment operable to reach a braze temperature sufficient to melt at least a portion of a braze material. The system also includes a component within the environment, the component including a base having a base surface, a recess depending from the base surface into the base to an inner edge, and a braze material within the recess and forming a cap above the base surface. The braze material fills the recess from the cap to the inner edge. The cap has an exposed braze surface. The system also includes an insulation layer that at least partially covers the exposed braze surface.

Abstract: A method for treating a turbine diaphragm and a treated turbine diaphragm are provided. The method includes the step of removing a portion of the turbine diaphragm. The method further includes the step of forming a coupon having a geometry that corresponds to the portion of the turbine diaphragm removed. The method further includes joining the coupon to the turbine diaphragm. At least a portion of the coupon is a pre-sintered preform. The treated turbine diaphragm includes a substrate and a coupon joined to the substrate, wherein at least a portion of the coupon is a pre-sintered preform.

Abstract: A method of repairing a superalloy component includes subjecting the superalloy component, including a repair area, to a phase agglomeration cycle, which includes stepped heating and controlled cooling of the component. The method further includes applying weld material to the repair area to create a weld surface; and covering the weld surface with brazing material. The component is then subjected to a braze cycle to produce a brazed component. The brazed component is cleaned, and the cleaned component is subjected to a restorative heat treatment to restore the microcrystalline structure and mechanical properties of the component.

Abstract: A method includes heating a brazing material in a braze chamber of a first component to a braze temperature to melt the brazing material. The brazing material flows from the braze chamber, through at least one internal channel of the first component, and into a braze gap between the first component and a second component to braze the first component to the second component. A brazed article includes a first component having a braze chamber and at least one internal channel extending from the braze chamber to an external surface, a second component having at least one braze surface separated from the external surface of the first component by a braze gap, and a braze material in the braze gap. A braze assembly includes a first component, a second component, and a brazing material in the braze chamber.

Abstract: A process includes agitating at least one core of a core alloy together with a braze binder to form at least one coated core comprising the at least one core coated with a first layer of the braze binder. The process also includes agitating the at least one coated core together with a powder composition comprising a first metal powder of a first alloy and a second metal powder of a second alloy to form a green preform having a first powder composition layer of the first alloy and the second alloy. The process further includes sintering the green preform to form at least one hybrid pre-sintered preform. A green preform includes a core, a first layer of a braze binder coated on the core, and a powder composition coated on the first layer. A hybrid pre-sintered preform includes a core and a first layer sintered to the core.

Abstract: A method for counteracting tensile stress in an article is disclosed, including heating the article and applying compressive stress to the article along a compressive stress vector, the compressive stress vector including a compressive stress vector component opposite in direction to a tensile stress vector of a thermally-induced tensile stress of the article. The compressive stress is applied by thermally-induced autogenous pressure by a fixture contacting the article. A fixture for counteracting tensile stress is disclosed, including a first compression member and a second compression member, and a position lock connecting the first compression member to the second compression member and reversibly fixing the first compression member relative to the second compression member. The first compression member and the second compression member include compressive surfaces having mating conformations for surfaces of an article. The position lock includes a material composition.

Abstract: A fixture and method for resistance welding of at least one pad to at least one surface of an article is disclosed. The method includes mounting the article in the fixture, placing the at least one pad on the at least one surface of the article, positioning a first electrode of a resistance welding apparatus to the at least one pad and a second electrode of the resistance welding apparatus to the article, and applying pressure and electric current across the at least one pad and the at least one surface. The fixture includes a first, second and third support element, which, respectively, include a first, second and third contact surface being adapted and disposed to support a first, second and third portion of the article. The first, second and third contact surfaces are each inelastic and electrically insulating. The fixture is arranged and disposed to non-rotatably cradle the article.

Abstract: A method to repair an opening in a metallic device including: mount the device on a positioner; while the device is mounted on the positioner, sense and record positions of a surface of an opening in the device using a probe operated by a manipulator; based on the recorded positions determine a centerline and diameter of the opening; orient a digital model of the opening with respect to the opening of the device based on the centerline and diameter of the opening, and apply an weld or cladding to the opening by a welding torch maneuvered automatically by the manipulator while the device is mounted to the positioner and based on the oriented digital model of the opening.

Abstract: A process includes agitating at least one core of a core alloy together with a braze binder to form at least one coated core comprising the at least one core coated with a first layer of the braze binder. The process also includes agitating the at least one coated core together with a powder composition comprising a first metal powder of a first alloy and a second metal powder of a second alloy to form a green preform having a first powder composition layer of the first alloy and the second alloy. The process further includes sintering the green preform to form at least one hybrid pre-sintered preform. A green preform includes a core, a first layer of a braze binder coated on the core, and a powder composition coated on the first layer. A hybrid pre-sintered preform includes a core and a first layer sintered to the core.

Abstract: The present application provides a method of repairing a turbine blade. The method may include the steps of removing an existing tip cap from the turbine blade in whole or in part, machining the turbine blade to form a machined groove, positioning an insert in the machined groove, welding the insert to the turbine blade, and brazing the turbine blade.

Abstract: A method for treating a turbine diaphragm and a treated turbine diaphragm are provided. The method includes the step of removing a portion of the turbine diaphragm. The method further includes the step of forming a coupon having a geometry that corresponds to the portion of the turbine diaphragm removed. The method further includes joining the coupon to the turbine diaphragm. At least a portion of the coupon is a pre-sintered preform. The treated turbine diaphragm includes a substrate and a coupon joined to the substrate, wherein at least a portion of the coupon is a pre-sintered preform.

Abstract: A method for counteracting tensile stress in an article is disclosed, including heating the article and applying compressive stress to the article along a compressive stress vector, the compressive stress vector including a compressive stress vector component opposite in direction to a tensile stress vector of a thermally-induced tensile stress of the article. The compressive stress is applied by thermally-induced autogenous pressure by a fixture contacting the article. A fixture for counteracting tensile stress is disclosed, including a first compression member and a second compression member, and a position lock connecting the first compression member to the second compression member and reversibly fixing the first compression member relative to the second compression member. The first compression member and the second compression member include compressive surfaces having mating conformations for surfaces of an article. The position lock includes a material composition.

Abstract: A method of brazing a treatment area of a load-bearing component includes applying a repair material over the treatment area of the component and positioning an induction brazing coil having a geometry corresponding to the treatment area over the repair material and the treatment area. The method further includes heating the repair material utilizing the induction brazing coil to a temperature sufficient to cause at least partial melting of the repair material, thereby effecting a brazed joint between the treatment area and the repair material.

Abstract: A method to repair an opening in a metallic device including: mount the device on a positioner; while the device is mounted on the positioner, sense and record positions of a surface of an opening in the device using a probe operated by a manipulator; based on the recorded positions determine a centerline and diameter of the opening; orient a digital model of the opening with respect to the opening of the device based on the centerline and diameter of the opening, and apply an weld or cladding to the opening by a welding torch maneuvered automatically by the manipulator while the device is mounted to the positioner and based on the oriented digital model of the opening.