Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.

Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are compounds that modulate splicing of a pre-mRNA, encoded by genes, and methods of treating diseases and conditions associated with gene expression or activity of proteins encoded by genes.

Abstract: An integrated drug selection system centered around point-of-care dispensing assembly that provides a practical, cost effective, and convenient way to optimize and individualize drug treatments. Through the cloud-based platform the dispensing assembly can be linked to the patient-user, prescriber-user, pharmacy-user, and the like, via network communication protocols and techniques. The dispensing assembly can include a drug reservoir assembly and a drug dispensing section (or base). The drug reservoir assembly is rotated between one or more rotatable drug reservoirs to dispense different drugs. The system includes a cloud-based platform that uses software to process and facilitate dispensing, treatments, data, monitoring, notifications, and trials, including treatment of specific health conditions.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Systems and methods are described for providing variable-length media clips based upon a received media stream. An exemplary system for providing media clips to users includes a database comprising a list of rules associated with a plurality of programs, as well as a first server and a second server. The first server receives information about a particular program being viewed by a media player and obtains rules from the database for the identified program that are transmitted to the media player. The second server receives a media clip of the particular program being viewed from the media player, wherein the media clip is created at the media player in accordance with the rules corresponding to the program, and subsequently makes the media clip available to the users.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: A cleaning pad includes a mounting surface disposed on a top side of the cleaning pad. The mounting surface is configured to provide a mechanical connection to an autonomous cleaning robot. The cleaning pad includes a first outer layer disposed on a bottom side of the cleaning pad, the first outer layer having a first coefficient of friction; and a second outer layer disposed on the bottom side of the cleaning pad, the second outer layer having a second coefficient of friction less than the first coefficient of friction.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.