Patents by Inventor Brian Metcalf

Brian Metcalf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20060020133
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: June 27, 2005
    Publication date: January 26, 2006
    Inventors: Chu-Biao Xue, Changsheng Zheng, Hao Feng, Michael Xia, Joseph Glenn, Ganfeng Cao, Brian Metcalf
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20060009491
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 12, 2006
    Inventors: Wenqing Yao, Colin Zhang, Konstantinos Agrios, Brian Metcalf, Jincong Zhuo
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20060009471
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 12, 2006
    Inventors: Wenqing Yao, Meizhong Xu, Colin Zhang, Konstantinos Agrios, Brian Metcalf, Jincong Zhuo
  • N-substituted piperidines and their use as pharrmaceuticals
    Publication number: 20060004049
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: January 5, 2006
    Inventors: Wenqing Yao, Meizhong Xu, Colin Zhang, Yanlong Li, Jincong Zhuo, Brian Metcalf
  • 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20060004018
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: June 27, 2005
    Publication date: January 5, 2006
    Inventors: Chu-Biao Xue, Changsheng Zheng, Hao Feng, Michael Xia, Joseph Glenn, Ganfeng. Cao, Brian Metcalf
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20050288338
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor MR, and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: December 29, 2005
    Inventors: Wenqing Yao, Colin Zhang, Meizhong Xu, Jincong Zhuo, Chunhong He, Brian Metcalf
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20050288317
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: June 23, 2005
    Publication date: December 29, 2005
    Inventors: Wenqing Yao, Yanlong Li, Meizhong Xu, Jincong Zhuo, Colin Zhang, Brian Metcalf
  • Amido compounds and their use as pharmaceuticals
    Publication number: 20050282858
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: May 4, 2005
    Publication date: December 22, 2005
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
  • 3-(4-Heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
    Publication number: 20050267146
    Abstract: The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
    Type: Application
    Filed: May 10, 2005
    Publication date: December 1, 2005
    Inventors: Chu-Biao Xue, Changsheng Zheng, Ganfeng Cao, Hao Feng, Michael Xia, Rajan Anand, Joseph Glenn, Brian Metcalf
  • Piperazinylpiperidine derivatives as chemokine receptor antagonists
    Publication number: 20050261310
    Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
    Type: Application
    Filed: April 12, 2005
    Publication date: November 24, 2005
    Inventors: Chu-Biao Xue, Ganfeng Cao, Taisheng Huang, Lihua Chen, Ke Zhang, Anlai Wang, David Meloni, Rajan Anand, Joseph Glenn, Brian Metcalf
  • Motilide compounds
    Patent number: 6946482
    Abstract: Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: September 20, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel V. Santi, Brian Metcalf, Christopher Carreras, Yaoquan Liu, Robert McDaniel, Eduardo J. Rodriguez
  • 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
    Publication number: 20050192302
    Abstract: The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 1, 2005
    Inventors: Chu-Biao Xue, Brian Metcalf, Amy Han, Darius Robinson, Changsheng Zheng, Anlai Wang, Yingxin Zhang
  • Epothilone derivatives and methods for making and using the same
    Patent number: 6893859
    Abstract: This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: May 17, 2005
    Assignee: KOSAN Biosciences, Inc.
    Inventors: Gary Ashley, Robert L. Arslanian, John Carney, Brian Metcalf, Li Tang
  • Epothilone derivatives and methods for making and using the same
    Publication number: 20050038086
    Abstract: This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
    Type: Application
    Filed: May 12, 2004
    Publication date: February 17, 2005
    Inventors: Gary Ashley, Robert Arslanian, John Carney, Brian Metcalf, Li Tang
  • Aza spiro alkane derivatives as inhibitors of metalloproteases
    Publication number: 20040259896
    Abstract: The present invention provides a compound of Formula I or Formula II: 1
    Type: Application
    Filed: April 23, 2004
    Publication date: December 23, 2004
    Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Fenglei Zhang, Brian Metcalf
  • Laulimalide derivatives
    Patent number: 6815463
    Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: November 9, 2004
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Brian Metcalf
  • Motilide compounds
    Publication number: 20040147461
    Abstract: The present invention provides novel macrolide compounds of the formulas 1
    Type: Application
    Filed: November 12, 2003
    Publication date: July 29, 2004
    Inventors: Gary Ashley, Brian Metcalf, Zong-Qiang Tian, Daniel Santi
  • Motilide compounds
    Publication number: 20040138150
    Abstract: Motilide compounds having the formula (I), 1
    Type: Application
    Filed: August 26, 2003
    Publication date: July 15, 2004
    Inventors: Daniel V. Santi, Brian Metcalf, Christopher Carreras, Yaoquan Liu, Robert McDaniel, Eduardo J. Rodriguez
  • Laulimalide derivatives
    Patent number: 6670389
    Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: December 30, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Brian Metcalf
  • Novel epothilone compounds and methods for making the same
    Publication number: 20030219877
    Abstract: The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by chemical synthesis.
    Type: Application
    Filed: November 14, 2002
    Publication date: November 27, 2003
    Inventors: Li Tang, Brian Metcalf, Leonard Katz, Gary Ashley