Patents by Inventor Brian Metcalf

Brian Metcalf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Laulimalide derivatives
    Publication number: 20030195181
    Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
    Type: Application
    Filed: February 10, 2003
    Publication date: October 16, 2003
    Inventors: Gary Ashley, Brian Metcalf
  • Epothilone compounds and methods for making and using the same
    Patent number: 6589968
    Abstract: This present invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: July 8, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Robert L. Arslanian, John R. Carney, Brian Metcalf
  • Maytansines and maytansine conjugates
    Publication number: 20030109682
    Abstract: Cytotoxin-targeting molecule conjugates comprising cytotoxin and an antibody, growth factor, or polysaccharide together with a pH-sensitive or redox potential-sensitive linker. Novel ansamitocins and recombinant genes and organisms that produce them. The use of the described conjugates in the treatment of cancer and other hyperproliferation diseases.
    Type: Application
    Filed: September 3, 2002
    Publication date: June 12, 2003
    Inventors: Daniel Santi, David C. Myles, Brian Metcalf, C. Richard Hutchinson, Gary Ashley
  • Epothilone derivatives and methods for making and using the same
    Publication number: 20030045711
    Abstract: This invention relates to compounds of formula (I) 1
    Type: Application
    Filed: April 2, 2002
    Publication date: March 6, 2003
    Inventors: Gary Ashley, Robert L. Arslanian, John Carney, Brian Metcalf, Li Tang
  • Epothilone derivatives and methods for making and using the same
    Publication number: 20030023082
    Abstract: The present invention relates to bicyclic compounds wherein one of the cyclic moieties is a 16-membered macrocycle and to methods for making and using these compounds.
    Type: Application
    Filed: May 13, 2002
    Publication date: January 30, 2003
    Inventors: Gary Ashley, Brian Metcalf
  • Epothilone derivatives and methods for making and using the same
    Publication number: 20020193361
    Abstract: The present invention relates to 16-membered macrocyclic compounds.
    Type: Application
    Filed: April 3, 2001
    Publication date: December 19, 2002
    Inventors: Gary Ashley, Brian Metcalf
  • Epothilone derivatives and methods for making and using the same
    Patent number: 6489314
    Abstract: The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula are provided wherein: R1, R2, R3, and R5 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl; R4 is hydrogen, halogen, C1-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 haloalkyl, aryl, —C(═O)R6, —C(═O)OR6, —NR6R7 where R6 and R7 are each independently hydrogen, C1-C10 aliphatic, aryl or alkylaryl; W is O, NR8 where R8 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or alkylaryl; X is O, CH2 or a carbon-carbon double bond; Y is absent or a C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl; and Ar is aryl; provided that 10,11-dehydroepothilone C is excluded.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: December 3, 2002
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Brian Metcalf
  • Epothilone compounds and methods for making and using the same
    Publication number: 20020156110
    Abstract: The present invention relates to compounds of the formula: 1
    Type: Application
    Filed: April 3, 2001
    Publication date: October 24, 2002
    Inventors: Robert L. Arslanian, John R. Carney, Brian Metcalf
  • Fermentation process for epothilones
    Publication number: 20020137152
    Abstract: Desoxyepothilone compounds are produced by fermentation of an epothilone producing microorganism in the presence of a P450 enzyme inhibitor.
    Type: Application
    Filed: July 25, 2001
    Publication date: September 26, 2002
    Inventors: Daniel Santi, Brian Metcalf, Gary Ashley
  • Laulimalide derivatives
    Publication number: 20020128471
    Abstract: Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
    Type: Application
    Filed: February 8, 2002
    Publication date: September 12, 2002
    Inventors: Gary Ashley, Brian Metcalf
  • Motilide compounds
    Publication number: 20020094962
    Abstract: The present invention provides novel macrolide compounds of the formulas 1
    Type: Application
    Filed: November 21, 2001
    Publication date: July 18, 2002
    Inventors: Gary Ashley, Brian Metcalf, Zong-Qiang Tian, Daniel Santi
  • METHOD FOR SCREENING COMPOUNDS WHICH INTERACT WITH THE L-ENANTIOMER OF A TARGET RNA
    Publication number: 20010007743
    Abstract: A method of identifying compounds which interact, directly or indirectly, with a target molecule of interest, wherein the target molecule of interest is an RNA, comprises screening compounds for interaction with the (L)-enantiomer of the said RNA, and identifying, as hits, the enantiomers of those compounds for which a said interaction is detected.
    Type: Application
    Filed: May 26, 1999
    Publication date: July 12, 2001
    Inventors: DAVID JUSTIN CHARLES KNOWLES, BRIAN METCALF, NEVILLE HUBERT NICHOLSON, NEIL DAVID PEARSON, CATHERINE DENISE PRESCOTT