Patents by Inventor Brian Orr

Brian Orr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8399671
    Abstract: The present disclosure generally relates to methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydromorphone, hydrocodone, or a derivative thereof, by means of a non-catalytic hydrogenation reaction of thebaine, oripavine or a derivative thereof, respectively, using a hydrazide reagent, followed by hydrolysis of the hydrogenated intermediate at a low temperature and for a short period of time. Additionally, the present disclosure relates to a composition comprising the desired hydromorphone, hydrocodone, or a derivative thereof, in combination with a 6-beta compound that is structurally related thereto.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: March 19, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Brian Orr, William E. Dummitt
  • Patent number: 8232397
    Abstract: The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Brenda E. Allen, Esa T. Jarvi, Dennis J. Kalota, James R. Meyer, Keith G. Tomazi, Anthony Mannino, Brian Orr
  • Patent number: 8232396
    Abstract: The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Brian Orr, Miranda Steele
  • Publication number: 20120071659
    Abstract: The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 22, 2012
    Applicant: Mallinckrodt LLC
    Inventors: Brian ORR, Joseph P. HAAR, JR., George H. KLEMM, Keith G. TOMAZI
  • Publication number: 20110296305
    Abstract: Methods and apparatus are provided for matching media files stored in a media player device to media files stored in a computing device. In one embodiment, a method includes scanning a media player device for one or more media files, detecting an identifier associated with each media file stored on the media player device, wherein identifiers are generated by a media management application, and checking if detected identifiers associated with media files stored in the media player device correspond to identifiers associated with media files stored in the computing device. The method may also include determining one or more graphical indicators for a user interface of the media management application based on said checking. According to another embodiment, a user interface may be provided for a media management application by a computing device.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 1, 2011
    Applicant: SONY CORPORATION
    Inventors: Brian Orr, Anton Jedlovsky, Steven Brenneman
  • Publication number: 20110296325
    Abstract: A device and methods are provided for operating a computing device to display a user interface for an application. In one embodiment a method includes executing code of an application program stored in the memory to display a user interface on the computing device, and detecting a display command in the code for an element of the user interface during execution of the application program, wherein the display command identifies a format identifier for the element. The method further includes determining one or more display characteristics of the element based on the format identifier, wherein the code includes a format identifier table defining one or more display characteristics of the format identifier, and displaying the element by the computing device, wherein display includes data from the display command based on characteristics of the format identifier determined from the format identifier table.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 1, 2011
    Applicant: Sony Corporation
    Inventor: Brian Orr
  • Publication number: 20110296047
    Abstract: Methods and apparatus are provided for seamless playback of media files by an application of a computing device. In one embodiment a method includes detecting a user selection for playback of one or more media files by the application, initiating playback of a first media file by the application based on the selection, and determining a time period to pre-load a second media file during playback of the first media file. The method may further include pre-loading data for the second media file, initiating playback of a buffer portion following an endpoint of the first media file, and continuing playback of the second media file following the endpoint of the buffer portion.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 1, 2011
    Applicant: Sony Corporation
    Inventor: Brian Orr
  • Publication number: 20110071297
    Abstract: The present disclosure generally relates to methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydromorphone, hydrocodone, or a derivative thereof, by means of a non-catalytic hydrogenation reaction of thebaine, oripavine or a derivative thereof, respectively, using a hydrazide reagent, followed by hydrolysis of the hydrogenated intermediate at a low temperature and for a short period of time. Additionally, the present disclosure relates to a composition comprising the desired hydromorphone, hydrocodone, or a derivative thereof, in combination with a 6-beta compound that is structurally related thereto.
    Type: Application
    Filed: September 20, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt inc.
    Inventors: Brian Orr, William E. Dummitt
  • Publication number: 20100197921
    Abstract: The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Application
    Filed: June 16, 2008
    Publication date: August 5, 2010
    Inventors: Christopher W. Grote, Brian Orr, Tao Jiang, Gary L. Cantrell
  • Publication number: 20100087647
    Abstract: The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Brenda E. Allen, Esa T. Jarvi, Dennis J. Kalota, James R. Meyer, Keith G. Tomazi, Anthony Mannino, Brian Orr
  • Publication number: 20100081813
    Abstract: The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Brian Orr, Miranda Steele
  • Patent number: 7491878
    Abstract: A music generation engine automatically generates musical compositions by accessing musical sections and corresponding properties including similarity factors that provide a quantified indication of the similarity of musical sections to one another (e.g., a percentage of similarity). A sequential relationship of the musical sections is then determined according to an algorithmic process that uses the similarity factors to assess the desirability of the sequential relationship. The algorithmically created musical composition may then be stored, such as by rendering the composition as an audio file or by storing a library file that refers to the musical sections. The created musical composition may include layers respectively having different audio elements such that the created musical composition has a first dimension along a timeline and a second dimension that provides a depth based upon the presence of different audio elements.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: February 17, 2009
    Assignees: Sony Corporation, Sony Creative Software, Inc.
    Inventor: Brian Orr
  • Patent number: 7325361
    Abstract: A modular drive assembly for a sliding door, comprising: a guide track having a hinge slidably received therein; a pair of pulleys disposed on either end of the guide track; a pair of cables each having an end that is secured to the hinge and the other end is secured to a cable drum of a motor drive unit mounted to the guide track, the motor drive unit being configured to rotate the cable drum, wherein the cable drum is also capable of freely rotating within the motor drive unit when the motor drive unit is not rotating the cable drum, wherein rotation of the cable drum causes the hinge to move in the guide track as one of the cables wraps onto the cable drum while the other one of the cables wraps off of the cable drum.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: February 5, 2008
    Assignee: Delphi Technologies, Inc.
    Inventors: Lloyd W. Rogers, Jr., Brian Orr, Jeff S. Hamminga, Theodore J. Lindsay
  • Publication number: 20070221044
    Abstract: A music generation engine automatically generates musical compositions by accessing musical sections and corresponding properties including similarity factors that provide a quantified indication of the similarity of musical sections to one another (e.g., a percentage of similarity). A sequential relationship of the musical sections is then determined according to an algorithmic process that uses the similarity factors to assess the desirability of the sequential relationship. The algorithmically created musical composition may then be stored, such as by rendering the composition as an audio file or by storing a library file that refers to the musical sections. The created musical composition may include layers respectively having different audio elements such that the created musical composition has a first dimension along a timeline and a second dimension that provides a depth based upon the presence of different audio elements.
    Type: Application
    Filed: February 13, 2007
    Publication date: September 27, 2007
    Inventor: Brian Orr
  • Publication number: 20060225358
    Abstract: A drive assembly for a vehicle door, comprising: a motor having a driving member; a housing having a shaft rotatably received therein; an input member being rotatably received upon the shaft, the input member being operatively associated with the driving member, wherein rotation of the driving member causes rotation of the input member; an armature mounted on the input member; a rotor fixedly secured to the shaft, the rotor being cylindrical in shape and has a plurality of teeth positioned along the periphery of the rotor, the teeth being positioned in an equidistant manner; a coil mounted to the housing, the coil providing magnetic flux lines through the rotor to attract the armature when the coil is energized; and an inductance sensor assembly mounted to the housing in a facing spaced relationship with respect to the plurality of teeth of the rotor, wherein rotational speed and direction of the rotor is detected by the inductance sensor assembly.
    Type: Application
    Filed: April 7, 2006
    Publication date: October 12, 2006
    Inventors: Ronald Haag, Joseph Johnson, Brian Orr
  • Publication number: 20060071505
    Abstract: An automotive vehicle has a power operated lift-gate that is opened and closed by two drive units. The typical drive unit has a guide channel, an attachment assembly that is disposed in the guide channel, a flexible drive member that is attached to the attachment assembly and formed in a loop for moving the attachment assembly in the guide channel. The flexible drive member is trained solely around two pulleys at the respective opposite ends of the guide channel to form the flexible drive member in a narrow loop. One of the pulleys is an idler pulley that is part of an adjustable pulley assembly and the other pulley is driven by a power unit that is attached to the guide channel. The adjustable pulley assembly adjusts the distance between the pulleys to take up slack in the flexible drive member.
    Type: Application
    Filed: August 31, 2005
    Publication date: April 6, 2006
    Inventors: Michael Ciavaglia, Joseph Johnson, Lloyd Rogers, Howard Kuhlman, Brian Orr, John Rice, Eric Hansen
  • Publication number: 20040221511
    Abstract: A modular drive assembly for a sliding door, comprising: a guide track having a hinge slidably received therein; a pair of pulleys disposed on either end of the guide track; a pair of cables each having an end that is secured to the hinge and the other end is secured to a cable drum of a motor drive unit mounted to the guide track, the motor drive unit being configured to rotate the cable drum, wherein the cable drum is also capable of freely rotating within the motor drive unit when the motor drive unit is not rotating the cable drum, wherein rotation of the cable drum causes the hinge to move in the guide track as one of the cables wraps onto the cable drum while the other one of the cables wraps off of the cable drum.
    Type: Application
    Filed: March 11, 2004
    Publication date: November 11, 2004
    Inventors: Lloyd W. Rogers, Brian Orr, Jeff S. Hamminga, Theodore J. Lindsay
  • Publication number: 20040127467
    Abstract: A new and efficient synthesis of the (+)-pancratistatin phosphate prodrug 2a has been accomplished. Selective protection (tetraacetate 4) of (+)-pancratistatin (1a) was followed by phosphorylation (to 5) with dibenzyl chlorophosphite (prepared in situ from dibenzyl phosphite). Cleavage of the acetate (with sodium methoxide) and benzyl (by hydrogenolysis) protecting groups followed by concomitant reaction with two equivalents of sodium methoxide afforded good yield of disodium (+)-pancratistatin phosphate (2a). Further increases in yields of the prodrug (2a) were realized by avoiding heat in the final purification steps. Fourteen (2b-o) additional metal and ammonium derived phosphate prodrugs were also synthesized.
    Type: Application
    Filed: October 16, 2003
    Publication date: July 1, 2004
    Inventors: George R Pettit, Brian Orr, Sylvie Ducki
  • Patent number: 6623396
    Abstract: A differential gear assembly including a differential housing. A pair of side gears substantially axially aligned and spaced apart from each other, wherein the side gears are adapted to be supported by the differential housing and to engage axle shafts. A pair of pinion gears substantially axially aligned and spaced apart from each other, wherein the pinion gears are adapted to engage the side gears. A ring gear is mounted externally to the differential housing and a pinion pin engages and extends diametrically across the ring gear. The ring gear includes features adapted to receive the ends of the pinion pin and to position the pinion pin relative to the ring gear such that a center of mass of the ring gear is aligned with a center of mass of the pinion pin.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: September 23, 2003
    Assignee: Visteon Global Technologies, Inc.
    Inventors: Norman Szalony, Richard Krzesicki, John Rutt, Brian Orr
  • Publication number: 20030144106
    Abstract: A differential gear assembly including a differential housing. A pair of side gears substantially axially aligned and spaced apart from each other, wherein the side gears are adapted to be supported by the differential housing and to engage axle shafts. A pair of pinion gears substantially axially aligned and spaced apart from each other, wherein the pinion gears are adapted to engage the side gears. A ring gear is mounted externally to the differential housing and a pinion pin engages and extends diametrically across the ring gear. The ring gear includes features adapted to receive the ends of the pinion pin and to position the pinion pin relative to the ring gear such that a center of mass of the ring gear is aligned with a center of mass of the pinion pin.
    Type: Application
    Filed: January 31, 2002
    Publication date: July 31, 2003
    Inventors: Norman Szalony, Richard Krzesicki, John Rutt, Brian Orr