Patents by Inventor Brian Reed

Brian Reed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210148921
    Abstract: Aspects of the application provide methods of preparing an enriched sample for polypeptide sequencing, and compositions, kits and devices useful for the same.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 20, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Matthew Dyer
  • Publication number: 20210147474
    Abstract: Aspects of the application provide methods of preparing a multiplexed sample for polypeptide sequencing, and compositions, kits and devices useful for the same.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 20, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Matthew Dyer, Brian Reed
  • Publication number: 20210148922
    Abstract: Provided herein are methods of single-polypeptide sequencing and reconstruction. Also provided herein are compositions, kits and devices useful for the same.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 20, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Matthew Dyer, Brian Reed
  • Publication number: 20210149625
    Abstract: Systems, methods, and software are disclosed herein for enhancing the content capture experience on computing devices. In an implementation, a combined user input comprises a voice signal and a touch gesture sustained at least partially coincident with the voice signal. An occurrence of the combined user input triggers the identification of an associated content object which may then be associated with a captured version of the voice signal. Such an advance provides users with a new framework for interacting with their devices, applications, and surroundings.
    Type: Application
    Filed: November 14, 2019
    Publication date: May 20, 2021
    Inventors: Eddie Louis Mays, III, Hauke Antony Gentzkow, Austin Seungmin Lee, Alice Shirong Ferng, Aaron David Rogers, Lauren Diana Lo, Cadin Lee Batrack, Jonathan Reed Harris, Brian Scott Stucker, Becky Ann Brown
  • Publication number: 20210139973
    Abstract: Provided herein are methods of single-cell polypeptide and/or polynucleic acid sequencing, which facilitate the direct sequencing of a single cell without amplification. Also provided herein are compositions, kits and devices useful for the same.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 13, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Matthew Dyer, Brian Reed
  • Patent number: 11001875
    Abstract: Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided. In some aspects, methods of sequencing nucleic acids involve determining the luminescence lifetimes, and optionally luminescence intensities, of a series of luminescently labeled nucleotides incorporated during a nucleic acid sequencing reaction.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: May 11, 2021
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang
  • Patent number: 11003225
    Abstract: A computing device includes a first connector near a first wall. The first connector is in communication with a chip package positioned apart for the first wall via a first cable. The chip package includes a chip supported by a support layer. The chip can be supported by a substrate and/or a circuit board. A second connector can be positioned near a second wall and can also be in communication with the chip package via a second cable. If desired, the substrate or circuit board can include a signal board connector that is configured to engage board connectors terminated to ends of the first and second cables.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: May 11, 2021
    Assignee: Molex, LLC
    Inventors: Bruce Reed, Brian Keith Lloyd, Gregory Fitzgerald
  • Publication number: 20210123234
    Abstract: A modular panel assembly for use with, e.g., a shower enclosure. The modular panel assembly includes a plurality of panels, each panel having a first side surface and a second side surface. The modular panel assembly also include a plurality of channel members, wherein each channel member is configured to be coupled to an edge portion of one or more panels. Additionally, a plurality of brackets are provided, wherein each bracket is configured to hold both the first side surface and the second side surface of two or more of the plurality of panels and an end portion of one or more of the plurality of channel members.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 29, 2021
    Inventors: Patrick Van Kirk, Samuel Reed, Leo Volkov, Michael Minkovich, Michael Korsky, Marina Seredova, Brian Lieb
  • Publication number: 20210112313
    Abstract: Methods, systems, devices, and computer-program products are described herein for providing dynamic content serving. The dynamic content serving technology can identify, in real-time, programming arriving at a client device, identify a specific media segment being received and/or displayed, and determine which pre-stored substitute media segment may be used to replace the identified segment. A picture-in-picture channel can be used to display the substitute media segment.
    Type: Application
    Filed: October 12, 2020
    Publication date: April 15, 2021
    Applicant: INSCAPE DATA, INC.
    Inventors: Zeev Neumeier, Brian Reed
  • Publication number: 20210102180
    Abstract: Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.
    Type: Application
    Filed: June 26, 2020
    Publication date: April 8, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Manjula Pandey
  • Publication number: 20200395099
    Abstract: Described herein are systems and techniques for identifying polypeptides using data collected by a protein sequencing device. The protein sequencing device may collect data obtained from detected light emissions by luminescent labels during binding interactions of reagents with amino acids of the polypeptide. The light emissions may result from application of excitation energy to the luminescent labels. The device may provide the data as input to a trained machine learning model to obtain output that may be used to identify the polypeptide. The output may indicate, for each of a plurality of locations in the polypeptide, one or more likelihoods that one or more respective amino acids is present at the location. The output may be matched to an amino acid sequence that specifies a protein.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Michael Meyer, Brian Reed, Zhizhuo Zhang, Sabrina Rashid, Bradley Robert Parry
  • Publication number: 20200385801
    Abstract: Methods, compositions, systems, apparatus, and kits are provided for depositing samples onto surfaces. The samples can include one or more particles, and the surface can include one or more reaction chambers. In some embodiments, the depositing can include the use of companion particles in combination with sample particles.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 10, 2020
    Inventors: Todd REARICK, Jessica Lynn REED, Jason GIOIA, Devin DRESSMAN, Nicholas HAPSHE, Brian REED, John Andrew SHERIDAN
  • Patent number: 10816505
    Abstract: A sensor array includes a plurality of sensors. A sensor of the plurality of sensors has a sensor pad exposed at a surface of the sensor array. A method of treating the sensor array includes exposing at least the sensor pad to a wash solution including sulfonic acid and an organic solvent and rinsing the wash solution from the sensor pad.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 27, 2020
    Assignee: Life Technologies Corporation
    Inventors: James A. Ball, Brian Reed
  • Publication number: 20200291467
    Abstract: System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Craig Wenger, Mel Davey, Keith G. Flfe, Jimmy Jia, Brian Reed, Brett J. Gyarfas
  • Publication number: 20200282336
    Abstract: A method of recovering a bead support from an emulsion includes supplying an aqueous surfactant solution into a centrifuge tube; supplying a hydrophobic liquid over the surfactant solution in the centrifuge tube, wherein a ratio of the volume of the aqueous surfactant solution to the volume of the hydrophobic liquid is not greater than 0.5; and applying an emulsion over the hydrophobic liquid while centrifuging, the emulsion comprising a dispersed aqueous phase including the bead support, the emulsion breaking and material of the dispersed phase preferentially partitioning to the surfactant solution.
    Type: Application
    Filed: February 10, 2020
    Publication date: September 10, 2020
    Inventors: Brian REED, James A. BALL
  • Patent number: 10731209
    Abstract: Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 4, 2020
    Assignee: Quantum-Si Incorporated
    Inventors: James A. Ball, Jeremy Lackey, Brian Reed, Alexander Goryaynov, Jonathan M. Rothberg, Thomas Christian
  • Publication number: 20200232017
    Abstract: Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
    Type: Application
    Filed: January 23, 2020
    Publication date: July 23, 2020
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang, David Dodd
  • Patent number: 10711299
    Abstract: System and methods for identifying nucleotides based on data acquired from a sensor during sequencing of nucleic acids. The method may include obtaining characteristics of light detected from luminescent labels associated with the nucleotides during nucleotide incorporation events. The characteristics may include, for each nucleotide incorporation event, a temporal characteristic the light and an intensity characteristic of the light. The temporal characteristic representing a speed of decay of a probability of photon emission by a luminescent label after excitation. The method may further include grouping points representing the characteristics of the nucleotide incorporation events into groups of points. The individual points may represent at least the temporal characteristic and the intensity characteristic for a corresponding nucleotide incorporation event. The method may further include assigning the groups of points to individual nucleotides.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: July 14, 2020
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Craig Wenger, Mel Davey, Keith G. Fife, Jimmy Jia, Brian Reed, Brett J. Gyarfas
  • Publication number: 20200219590
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Application
    Filed: November 15, 2019
    Publication date: July 9, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
  • Publication number: 20200209254
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Application
    Filed: December 10, 2019
    Publication date: July 2, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg