Patents by Inventor Brian S. Miller
Brian S. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9186322Abstract: One aspect of the disclosure relates to a new form of lipid-complexed active platinum compound, which allows for high concentrations of platinum compound in the composition. For example, the concentration of cisplatin in the composition is higher at room temperature, e.g., about greater than 1.2 mg/mL, compared to 1 mg/mL in aqueous solution. In one embodiment, the present invention is directed to a composition comprising a lipid-complexed active platinum compound, wherein the complex has a lipid to drug (L/D) ratio of less than about 1 by weight, e.g. about 0.10 to 1, wherein the lipid-complexed active platinum compound comprises at least one lipid and at least one active platinum compound. In other embodiments, wherein lipid-complexed active platinum compound has an average volume-weighted diameter of about 0.5 to about 20 microns. In still other embodiments, the composition further comprises a liposome.Type: GrantFiled: February 7, 2008Date of Patent: November 17, 2015Assignee: Insmed IncorporatedInventors: Jin K. Lee, Brian S. Miller, Fangjun Wu, Lawrence T. Boni, Vladimir Malinin
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Publication number: 20140314835Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: ApplicationFiled: June 30, 2014Publication date: October 23, 2014Inventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 8802137Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: GrantFiled: March 29, 2010Date of Patent: August 12, 2014Assignee: Insmed IncorporatedInventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20110159079Abstract: Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.Type: ApplicationFiled: January 3, 2011Publication date: June 30, 2011Inventors: Zhili Li, Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 7879351Abstract: Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.Type: GrantFiled: April 6, 2006Date of Patent: February 1, 2011Assignee: Transave, Inc.Inventors: Zhili Li, Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20100260829Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: ApplicationFiled: March 29, 2010Publication date: October 14, 2010Applicant: Transave, Inc.Inventors: Lawrence Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Patent number: 7718189Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.Type: GrantFiled: July 19, 2005Date of Patent: May 18, 2010Assignee: Transave, Inc.Inventors: Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
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Publication number: 20100068257Abstract: Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.Type: ApplicationFiled: April 15, 2009Publication date: March 18, 2010Applicant: Transave, Inc.Inventors: Lawrence T. Boni, Brian S. Miller
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Patent number: 7544369Abstract: Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.Type: GrantFiled: October 29, 2003Date of Patent: June 9, 2009Assignee: Transave, Inc.Inventors: Lawrence T. Boni, Brian S. Miller
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Patent number: 7449320Abstract: The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising the use of the enzymatic compositions.Type: GrantFiled: March 3, 1999Date of Patent: November 11, 2008Assignee: Genencor International, Inc.Inventors: Brian S. Miller, Jayarama K. Shetty
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Publication number: 20080229409Abstract: An example display unit for facilitating operation of equipment includes a housing, an electronic display supported by the housing, and an electronic circuit located within the housing. The display unit may include one or more data receivers, such as a wireless receiver and/or an electrical interface. A biometric scanner, including a biometric sensor and proving an authorization signal when an authorized biometric input is detected by the biometric sensor, may be configured to electrically (and optionally mechanically) interconnect to the display unit. The example display unit receives an authorization status for operation of the equipment from the biometric scanner, and displays the authorization status and operational parameters relating to equipment use on the electronic display.Type: ApplicationFiled: March 3, 2008Publication date: September 18, 2008Inventors: Brian S. Miller, Jack Vaughan, Oscar A. Ledriere, Gino DiSimone
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Publication number: 20080223926Abstract: An example apparatus for allowing operation of equipment by an authorized operator comprises a biometric scanner receiving a biometric input from an authorized operator, and transmitting an authorization signal. The apparatus may further includes a base station that allows the equipment to operate while the base station receives the authorization signal from the biometric scanner, and which prevents the equipment from operating shortly after the authorization signal is no longer received from the biometric scanner.Type: ApplicationFiled: March 3, 2008Publication date: September 18, 2008Inventors: Brian S. Miller, Jack Vaughan, Oscar A. Ladriere, Gino DiSimone
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Publication number: 20080187578Abstract: One aspect of the disclosure relates to a new form of lipid-complexed active platinum compound, which allows for high concentrations of platinum compound in the composition. For example, the concentration of cisplatin in the composition is higher at room temperature, e.g., about greater than 1.2 mg/mL, compared to 1 mg/mL in aqueous solution. In one embodiment, the present invention is directed to a composition comprising a lipid-complexed active platinum compound, wherein the complex has a lipid to drug (L/D) ratio of less than about 1 by weight, e.g. about 0.10 to 1, wherein the lipid-complexed active platinum compound comprises at least one lipid and at least one active platinum compound. In other embodiments, wherein lipid-complexed active platinum compound has an average volume-weighted diameter of about 0.5 to about 20 microns. In still other embodiments, the composition further comprises a liposome.Type: ApplicationFiled: February 7, 2008Publication date: August 7, 2008Applicant: Transave, Inc.Inventors: Jin K. Lee, Brian S. Miller, Fangjun Wu, Lawrence T. Boni, Vladimir Malinin
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Patent number: 7399623Abstract: The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising the use of the enzymatic compositions.Type: GrantFiled: September 16, 2002Date of Patent: July 15, 2008Assignee: Genencor International, Inc.Inventors: Brian S. Miller, Jayarama K. Shetty
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Publication number: 20040142026Abstract: Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.Type: ApplicationFiled: October 29, 2003Publication date: July 22, 2004Applicant: Transave, Inc.Inventors: Lawrence T. Boni, Brian S. Miller
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Publication number: 20040101553Abstract: A composition and process for making the composition, the composition comprising a liposome and active platinum compound, the liposome containing one or more lipids, with a high active platinum compound to lipid ratio.Type: ApplicationFiled: August 4, 2003Publication date: May 27, 2004Applicant: Transave, Inc.Inventors: Jin Lee, Brian S. Miller, Fangjun Wu, Lawrence T. Boni
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Publication number: 20030022348Abstract: The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising the use of the enzymatic compositions.Type: ApplicationFiled: September 16, 2002Publication date: January 30, 2003Inventors: Brian S. Miller, Jayarama K. Shetty
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Publication number: 20030013180Abstract: The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions comprising the modified pullulanase, and methods for the saccharification of starch comprising the use of the enzymatic compositions.Type: ApplicationFiled: March 3, 1999Publication date: January 16, 2003Inventors: BRIAN S. MILLER, JAYARAMA K. SHETTY
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Patent number: 5079501Abstract: A pattern of electrodes, with electrical lead lines to the electrodes, are arried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.Type: GrantFiled: February 22, 1991Date of Patent: January 7, 1992Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Brian S. Miller, David R. Kaplan
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Patent number: 5072176Abstract: A pattern of electrodes, with electrical lead lines to the electrodes, are arried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.Type: GrantFiled: February 22, 1991Date of Patent: December 10, 1991Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Brian S. Miller, David R. Kaplan