Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

Abstract: Systems and methods include registering use of a virtual certification number (VCN) at a secure entity by receiving, at an external gateway, a registration request comprising an external request code and a primary account number (PAN), wherein the external request code is unique to the secure entity, determining that the external request code is an unregistered external request code, receiving a tokenized PAN based on the PAN, receiving an account identifier by applying the tokenized PAN to a certification mechanism tool application programing interface (API), generating a certification mechanism reference identifier by encrypting a certification mechanism associated with the account identifier and the tokenized PAN, updating a database to associate the certification mechanism reference identifier with the external request code, and transmitting, via the external gateway, a registration authentication to an external entity, the registration authentication comprising the external request code.

Abstract: Systems and methods include providing virtual certification number (VCN) authorizations to an external entity by receiving a plurality of secure entity global authorizations comprising global VCN authorizations and global primary account number (PAN) authorizations, identifying the global VCN authorizations, identifying a subset of the global VCN authorizations, each of the subset of the global VCN authorizations corresponding to an external entity authorization, comparing the subset of global VCN authorizations to previously provided VCN authorizations, to identify an unsent VCN authorization, storing a transmittable unsent VCN authorization based on the unsent VCN authorization, providing an unsent authorization indication to the external entity, receiving, from the external entity, a request for the unsent VCN authorization based on providing the unsent authorization indication to the external entity, and providing the transmittable unsent VCN authorization to the external entity, based on storing the tran

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Systems and methods for authorizing a source for virtual certification number (VCN) use include receiving a VCN use request from an external entity, the VCN use request including the VCN and transaction data associated with the VCN use request, determining that a VCN binding for the VCN is a strict binding, mapping the transaction data to a transaction source having a transaction source identifier based on the VCN binding being the strict binding, determining a VCN source identifier for the source associated with the VCN, based on a registration authentication of the VCN with the source, comparing the VCN source identifier to the transaction source identifier, determining that the VCN source identifier corresponds to the transaction source identifier based on comparing the VCN source identifier to the transaction source identifier, outputting an approved authorization indicating that the VCN is associated with the source and the source is the transaction source.

Abstract: A liquid fabric treatment composition suitable for encapsulation in a unit dose pack contains from about 3% by weight to about 8% by weight of an alcohol ethoxylate, from about 10% by weight to about 70% by weight of an encapsulated fragrance slurry; from about 0.5% by weight to about 5% by weight of a rheology modifier; from about 0.1% by weight to about 3% by weight of a pH adjusting agent; and from about to about 5% by weight to about 60% by weight of non-aqueous solvent. The liquid composition is stable at elevated temperatures and has a lower yield stress and a lower storage modulus than a composition having no alcohol ethoxylate.

Abstract: This disclosure describes systems, devices, apparatus, and methods, including computer programs encoded on storage media, for controlling a network with one or more access points (APs). A controller may be configured to schedule at least some resources of the one or more APs to improve network efficiency. The APs may measure and report a variety of information and statistics to the controller. The controller may determine one or more transmission parameters and one or more operations a given AP is permitted to perform during a respective time interval. The controller may communicate the one or more transmission parameters using an indication, such as a message. At least one AP associated with the controller may communicate with stations (STAs) using the one or more transmission parameters.

Abstract: Systems and methods include providing virtual certification number (VCN) authorizations to an external entity by receiving a plurality of secure entity global authorizations comprising global VCN authorizations and global primary account number (PAN) authorizations, identifying the global VCN authorizations, identifying a subset of the global VCN authorizations, each of the subset of the global VCN authorizations corresponding to an external entity authorization, comparing the subset of global VCN authorizations to previously provided VCN authorizations, to identify an unsent VCN authorization, storing a transmittable unsent VCN authorization based on the unsent VCN authorization, providing an unsent authorization indication to the external entity, receiving, from the external entity, a request for the unsent VCN authorization based on providing the unsent authorization indication to the external entity, and providing the transmittable unsent VCN authorization to the external entity, based on storing the tran

Abstract: Systems and methods for triggering a virtual certification number (VCN) generation for use at a source include receiving a VCN generation request from an external entity, the VCN generation request comprising an external request code, external risk signals, and one or more source data for the source, verifying a registration authentication of an account associated with the external request code by comparing the external request code to a database entry, identifying a certification mechanism reference identifier associated with the external request code based on verifying the registration authentication, generating a risk authentication based on a risk analysis conducted using the external risk signals and the external request code, identifying a source identifier based on the one or more source data, and generating the VCN based on the certification mechanism reference identifier and the source identifier.

Abstract: Systems and methods include registering use of a virtual certification number (VCN) at a secure entity by receiving, at an external gateway, a registration request comprising an external request code and a primary account number (PAN), wherein the external request code is unique to the secure entity, determining that the external request code is an unregistered external request code, receiving a tokenized PAN based on the PAN, receiving an account identifier by applying the tokenized PAN to a certification mechanism tool application programing interface (API), generating a certification mechanism reference identifier by encrypting a certification mechanism associated with the account identifier and the tokenized PAN, updating a database to associate the certification mechanism reference identifier with the external request code, and transmitting, via the external gateway, a registration authentication to an external entity, the registration authentication comprising the external request code.

Abstract: An organic colorant complex with the following general structure: ABn(DE)mTxQy wherein A is an organic chromophore; B is an electrophilic reactive group covalently bonded to A directly or through a linking group; D is a nucleophilic linking group covalently bonding B and E, selected from the group consisting of NR, O, S, and 4-oxyanilino (—HN-Ph-O—); wherein R is selected from the group consisting of H, alkyl, aryl, and E; E is an organic alkyl and aryl group or an end group; T is an ionic group covalently linked to A; Q is an organic cation, bonded to the organic chromophore A through ionic interaction with T; n, m, x, and y are independent integers from 1 to 10.

Abstract: The present invention relates to substrates comprising a coating on the surface thereof containing colorant complexes made from specific anionic dyes complexed with cationic compounds, such as substrates having a coating thereon intended to mimic the look and feel of leather. The inventive colored coatings have superior compatibility, transparency, solvent fastness, non-migration and water fastness properties.

Abstract: Novel coated substrates comprise a substrate and a coating thereon. The coating comprises a polymeric component and a colored oligomer. The colored oligomer is produced from a reactive dye with nucleophilic compounds, and optionally further complexed with organic cationic compounds.

Abstract: Novel coated substrates comprise a substrate and a coating thereon. The coating comprises a polymeric component and a colored oligomer. The colored oligomer is produced from a reactive dye with nucleophilic compounds, and optionally further complexed with organic cationic compounds.

Abstract: An organic colorant complex with the following general structure: ABn(DE)mTxQy wherein A is an organic chromophore; B is an electrophilic reactive group covalently bonded to A directly or through a linking group; D is a nucleophilic linking group covalently bonding B and E, selected from the group consisting of NR, O, S, and 4-oxyanilino (—HN-Ph-O—); wherein R is selected from the group consisting of H, alkyl, aryl, and E; E is an organic alkyl and aryl group or an end group; T is an ionic group covalently linked to A; Q is an organic cation, bonded to the organic chromophore A through ionic interaction with T; n, m, x, and y are independent integers from 1 to 10.

Abstract: Novel coated substrates comprise a substrate and a coating thereon. The coating comprises a polymeric component and a colored oligomer. The colored oligomer is produced from a reactive dye with nucleophilic compounds, and optionally further complexed with organic cationic compounds.

Abstract: Novel coated substrates comprise a substrate and a coating thereon. The coating comprises a polymeric component and a colored oligomer. The colored oligomer is produced from a reactive dye with nucleophilic compounds, and optionally further complexed with organic cationic compounds.

Abstract: A modular utensil holder is operable to hold a utensil and includes a case, a utensil-retaining assembly, and a removable case connector. The case includes wall structure that presents an elongated utensil-receiving opening. The utensil-retaining assembly is confined by the wall structure within the utensil-receiving opening to engage the utensil when the utensil is received in the opening. The case connector is fixed relative to the wall structure, with the case connectors of adjacent utensil holders being removably connectable so as to releasably secure the adjacent utensil holders to one another.