Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Pol?) activity, in particular inhibit Pol? activity by inhibiting ATP dependent helicase domain activity of Pol?. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers.

Abstract: Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.

Abstract: Providing deterministic frequency and voltage enhancements for a processor is disclosed. In an embodiment, a microcontroller on a processor identifies a plurality of parameters related to a processor, the plurality of parameters including at least a current supplied to the processor; determines, in dependence upon the plurality of parameters, one or more frequency scaling indexes including determining an effective switching capacitance ratio; identifies, in dependence upon the one or more frequency scaling indexes, a predetermined frequency parameter for the processor; and transitions, based on the frequency parameter, the processor to a target clock frequency.

Abstract: A system and method for managing energy consumption of one or more processor cores in a multicore processing device. The method includes recording an activity level of one or more processor cores within a multicore processing device and translating each activity level of the one or more processor cores to a respective charge value. The method also includes generating, at least partially subject to each translated charge value, one or more charge replenishment requests associated with the one or more processor cores. The method further includes determining the one or more charge replenishment requests exceeds a power delivery capacity to the multicore processing device. The method also includes regulating the processing activity of the one or more processor cores to decrease a power consumption for the one or more processing cores.

Abstract: Embodiments relate to a system and method for managing energy consumption of one or more processor cores in a multicore processing device. The method includes establishing a temporal interval that includes a plurality of temporal periods and an interval energy target for one or more processor cores. The method also includes determining for each temporal period a period energy target for the processor cores and determining a processor core throttling state for the processor cores. The method further includes adjusting the respective period energy target and the respective processor core throttling state at the beginning of each successive temporal period. The method also includes converging, subject to the adjusting, as each respective temporal period of the plurality of temporal periods is concluded, a total period energy consumption of the processor cores with the interval energy target.

Abstract: A hearing aid assembly includes a receiver speaker enclosed within a receiver housing. The receiver housing defines a circuitous receiver acoustic channel, wherein the receiver channel defines an open side along at least a portion of the receiver channel. The receiver channel also defines a pass-through passage extending from a first side of the receiver housing to a second side of the receiver housing, wherein the pass-through passage is partially defined by the wall defining a receiver opening. The hearing aid assembly also includes an earbud configured to fit over at least a portion of the receiver housing and partially cover the open side of the receiver channel.

Abstract: The present invention provides improved spectral signature strategies for use in a wide range of product and service applications. The present invention encodes spectral signature features into one or more optical brightener compounds and/or one or more infrared absorbing compounds. Equipment is modified with appropriate ultraviolet/violet or infrared LED illumination sources and corresponding detectors, optionally optical filters, and optionally mask elements, in order to read the spectral responses. These features desirably are used in combination with one or more other luminescent taggant compounds.

Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: Methods, systems, and computer-readable media for collecting route-based traffic metrics in a service-oriented system are disclosed. A first service in a service-oriented system receives an inbound request from a second service. From the inbound request, the first service extracts, a route identifier representing an upstream route including the second service. The first service stores the route identifier and a counter representing a number of inbound requests with the route identifier that have been received by the first service over a current window of time. The first service sends, to a traffic metric collection system, a metric message comprising the route identifier and the counter. Traffic metric data is determined by the traffic metric collection system using the metric message from the first service and one or more additional metric messages from one or more additional services. The traffic metric data indicates one or more flows of requests through the services.

Abstract: In some embodiments, a method receives a history of videos that were viewed on a video delivery system as a first sentence in a sequential order and a target video as a second sentence as input to a prediction network. The prediction network analyzes representations for the history of videos and a representation of the target video. The prediction network generates a session representation based on bidirectionally analyzing a sequence of the first representations and the second representation. The method uses the session representation to determine whether to recommend the target video.

Abstract: The disclosure provides compositions, methods, and devices for use in delivering Mitomycin-C(MMC), an antineoplastic chemotherapy drug often used for bladder instillations to treat bladder cancer, which degrades in both acidic and alkaline environments. The disclosure provides a solution of buffered MMC (or a different drug) in 50% propylene glycol that maintains a pH from 7.0 to 8.0 when introduced into acidic solutions (pH of 5.0) and is stable when stored at 2-8° C. for greater than 134 days. This formulation can be produced in an FDA registered 503B Outsourcing facility in a pre-filled, ready-to-administer syringe kit with pre-attached closed system transfer device and accessories required for bladder instillation.

Abstract: An additive manufacturing apparatus includes a stage configured to hold a component. A radiant energy device is operable to generate and project radiant energy in a patterned image. An actuator is configured to change a relative position of the stage relative to the radiant energy device. A resin management system includes a material deposition assembly upstream configured to deposit a resin on a resin support. The material deposition assembly includes a reservoir configured to retain a first volume of the resin and define a thickness of the resin on the resin support as the resin support is translated in an X-axis direction. The material deposition assembly further includes a vessel positioned above the reservoir in a Z-axis direction and configured to store a second volume of the resin. In addition, the material deposition assembly includes a conduit configured to direct the resin from the vessel to the reservoir.

Abstract: A large-scale radio frequency signal collection and processing system comprising a plurality of sensor systems mounted on a plurality of collection platforms that integrates a plurality of overlapping datasets with differing characteristics (e.g., different resolutions, different view angles, different heights, different time periods, unrelated types of data) to generate an enriched dataset or datasets using a variety of processing techniques (e.g., statistical analysis, signal processing, image processing) that allows for more comprehensive analysis of the radio frequency signal landscape than would be possible using any of the datasets individually, or in combination but without such integration.

Abstract: In some examples, a circuit includes a state machine. The state machine is configured to operate in a buck state in which the state machine is configured to control a power converter to operate in a buck mode of operation at a first frequency. The state machine is configured to determine that a switch time of the power converter has decreased to within a threshold amount of a minimum switch time for the power converter. The state machine is configured to, responsive to the switch time of the power converter having decreased to within the threshold amount of the minimum switch time for the power converter, transition from the buck state to a reduced frequency buck state in which the state machine is configured to control the power converter to operate in the buck mode of operation at a second frequency that is less than the first frequency.

Abstract: A bonding washer for making electrical connection between two metal pieces that are to be mechanically fastened together. The washer, to be interposed between the two metal pieces, may be constructed so as to fasten to one of the pieces before the two pieces are joined. Teeth on the washer, positioned at right angles to the plane of the washer, are forced into each of the two metal pieces when the fastener is tightened, making electrical connection between the two metal pieces.

Abstract: A reclamation system for an additive manufacturing apparatus can include a collection structure configured to remove at least a portion of the resin from a foil. A containment vessel can be configured to retain the resin removed from the foil. A drain can direct the resin from the containment vessel to a reservoir.

Abstract: An additive manufacturing apparatus can include a stage configured to hold one or more cured layers of resin that form a component. A radiant energy device can be operable to generate and project radiant energy in a patterned image. An actuator can be configured to change a relative position of the stage relative to the radiant energy device. A reclamation system can be downstream of the stage and can be configured to remove at least a portion of the resin from a resin support. The reclamation system can include a first collection structure configured to accept a resin support therethrough along a resin support movement direction. A first scraper is positioned within the first collection structure. The first scraper has an elongation axis that is offset from the resin support movement direction by an offset angle that is less than 90 degrees.

Abstract: Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.

Abstract: A wind turbine includes a nacelle, a generator housed with the nacelle, a rotor having a rotatable hub with at least one rotor blade mounted thereto, at least one shaft rotatably coupled to the hub for driving the generator, and a rotor lock arranged with the shaft(s) for locking the shaft(s) in a locked position. The wind turbine also includes a bolted-joint connection at an interface between the hub and the shaft(s). The bolted-joint connection includes a first plurality of fasteners extending through the hub, the shaft(s), and the rotor lock. As such, a load transfer path from the hub to the shaft(s) travels through each of the hub, the shaft(s), and the rotor lock so as to increase a load capacity of the interface.