Abstract: The present invention relates to novel substituted bridged urea compounds of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: Apparatuses, systems, and methods are disclosed for a complete diffuser and a two-part decorative diffuser cover. The two-part decorative diffuser cover has an inner cavity shaped to receive the complete diffuser. One part of the two-part decorative diffuser cover is removable couple to the complete diffuser. The two-part decorative diffuser cover forms a single decorative structure when both parts of the two-part decorative diffuser cover are joined together.

Abstract: The exemplary embodiments include a radio frequency antenna switch configured to reject harmonic frequencies. In addition, the harmonic-rejected radio frequencies of the radio frequency antenna switch may be tuned by use of a capacitor array. The capacitor array may be configured with fuse elements or by control logic.

Abstract: Apparatuses, systems, methods, and computer program products are disclosed for a diffuser and one or more removable diffuser covers. A removable diffuser cover comprises one or more decorative features. A cavity in a diffuser cover is shaped to receive a complete diffuser. A complete diffuser comprises a diffuser element that disperses a liquid into air within a diffuser chamber and a lid shaped to at least partially enclose an upper opening of the diffuser chamber. One or more openings are positioned to receive a dispersed liquid from a lid of a complete diffuser within a cavity and to allow the dispersed liquid to pass to an exterior of a removable diffuser cover.

Abstract: A device for supporting and installing a bearing assembly includes an inner ring having an inner ring axial face, an outer ring having an outer ring axial face and an outer diameter, and a plurality of rolling elements positioned between the inner ring and the outer ring. The device comprises a sleeve having an inner diameter sized and configured to receive and support the outer ring along the outer diameter, and a disc positioned within the sleeve. The disc includes a disc outer diameter sized and configured to permit sliding of the disc along the sleeve inner diameter in an axial direction of the sleeve and a disc face surface sized and configured to engage the inner ring axial face, or the outer ring axial face, or both when the bearing assembly is received in the sleeve.

Abstract: Apparatuses, systems, methods, and computer program products are disclosed for a diffuser and interchangeable cover. A complete diffuser includes a diffuser element that disperses a liquid into air within a diffuser chamber of the complete diffuser. A complete diffuser includes a lid shaped to at least partially enclose an upper opening of a diffuser chamber. A cover is removably couplable to a complete diffuser over a diffuser lid so that a dispersed liquid passes through one or more openings in the cover. A cover includes one or more decorative features having a different external shape than a complete diffuser that receives the cover.

Abstract: A counterbalance assembly for an appliance hinge has a base including first and second spaced-apart side walls and a transverse face wall. A channel is located between the first and second side walls. First and second notch portions are respectively located in the first and second side walls. A rotating cam is supported on the base and has a camshaft that extends between the side walls and that is adapted for rotation about an axis of rotation, a first end located in the first notch portion and a second end located in the second notch portion. A biasing spring has an inner end engaged with the base and an outer end spaced from the base. A spring rod includes an outer end operatively coupled to the spring and an inner end operatively coupled to the lever. The lever also pivotally connects to the lobe of the cam. A damper assembly is connected to the base and having a piston which is moved between a first position and a second position by the lever contacting the piston.

Abstract: A cable having a conducting member made from a nanostructure-based material, and a shielding layer made of nanostructure-based material. The shielding layer can be circumferentially situated about the conducting member so as to enhance conductivity along the conducting member. A coupling mechanism may be situated between the shielding layer and the conducting member so as to secure the shielding layer in its position on the conducting member. A method of making the cable is also disclosed.

Abstract: There is provided a system and method for communicating with a first peripheral device, of a plurality of peripheral devices, using a touch-sensitive system that has a processor and a touch surface. According to an exemplary embodiment, a method includes detecting, using the processor, a plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method further includes identifying, using the processor, the first peripheral device based on the plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method additionally includes communicating data, using the processor, to a receptive circuit of the first peripheral device in response to the identifying of the first peripheral device.

Abstract: Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: A counterbalance assembly for an appliance hinge has a base including first and second spaced-apart side walls and a transverse face wall. A channel is located between the first and second side walls. First and second notch portions are respectively located in the first and second side walls. A rotating cam is supported on the base and has a camshaft that extends between the side walls and that is adapted for rotation about an axis of rotation, a first end located in the first notch portion and a second end located in the second notch portion. A biasing spring has an inner end engaged with the base and an outer end spaced from the base. A spring rod includes an outer end operatively coupled to the spring and an inner end operatively coupled to the lever. The lever also pivotally connects to the lobe of the cam. A damper assembly is connected to the base and having a piston which is moved between a first position and a second position by the lever contacting the piston.

Abstract: A conductive adapter for carrying relatively high current from a source to an external circuit without degradation is provided. The adapter includes a conducting member made from a conductive nanostructure-based material and having opposing ends. The adapter can also include a connector portion positioned on one end of the conducting member for maximizing a number of conductive nanostructures within the conducting member in contact with connector portion, so as to enable efficient conduction between a nanoscale environment and a traditional electrical and/or thermal circuit system. The adapter can further include a coupling mechanism situated between the conducting member and the connector portion, to provide a substantially uniform contact between the conductive nanostructure-based material in the conducting member and the connector portion. A method for making such a conductive adapter is also provided.

Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: There is provided a system and method for communicating with a first peripheral device, of a plurality of peripheral devices, using a touch-sensitive system that has a processor and a touch surface. According to an exemplary embodiment, a method includes detecting, using the processor, a plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method further includes identifying, using the processor, the first peripheral device based on the plurality of touches on the touch surface of the touch-sensitive system that are made by the first peripheral device. The method additionally includes communicating data, using the processor, to a receptive circuit of the first peripheral device in response to the identifying of the first peripheral device.

Abstract: Embodiments of systems and methods are described for dynamically managing requests for computing capacity from a provider of computing resources. Illustratively, the computing resources may include program execution capabilities, data storage or management capabilities, network bandwidth, etc. The systems or methods automatically allocate computing resources for execution of one or more programs associated with the user. The systems and methods may enable the user to make changes to the allocated resources after execution of the one or more programs has started.

Abstract: A conductive adapter for carrying relatively high current from a source to an external circuit without degradation is provided. The adapter includes a conducting member made from a conductive nanostructure-based material and having opposing ends. The adapter can also include a connector portion positioned on one end of the conducting member for maximizing a number of conductive nanostructures within the conducting member in contact with connector portion, so as to enable efficient conduction between a nanoscale environment and a traditional electrical and/or thermal circuit system. The adapter can further include a coupling mechanism situated between the conducting member and the connector portion, to provide a substantially uniform contact between the conductive nanostructure-based material in the conducting member and the connector portion. A method for making such a conductive adapter is also provided.

Abstract: A hinge assembly includes a lever arm and a channel connected to the lever arm. The channel is adapted to be connected to an associated appliance door. A control link is pivotally connected to the lever arm. A slide body includes an inner end connected to the control link. The slide body is adapted for sliding movement in response to pivoting movement of the channel relative to the lever arm between a first (door-closed) position and a second (door-opened) position. A spring resiliently biases the channel toward the first position. A snubber system includes at least one snubber with a piston that is biased to an extended position and moveable to a retracted position against a fluid or other damping resistance during movement of the slide body away when the channel moves from the first position to the second position.

Abstract: A door closure device includes a pivot pin adapted to engage an associated appliance hinge, and a channel rotatably connected to the pivot pin and adapted to be connected to an associated appliance door. A cam is non-rotatably engaged with the pivot pin. The cam comprises a lobed edge including a closing portion. A spring rod is slidably engaged with the channel, and a cam follower is operably engaged with the spring rod. A spring is engaged between the spring rod and the channel and biases the cam follower into engagement with the lobed edge of the cam. The follower moves along the lobed edge of the cam when the channel is rotated relative to the cam and the spring induces a door-closing torque on the channel when the follower is engaged with the closing portion of the cam lobed edge.