Abstract: The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Abstract: A policy-driven automatic network remediation service is described, which resides on the network and is triggered when a network fault is detected. Once triggered, the service automatically connects to network devices in the topological locale of the detected fault and collects diagnostic information from the affected area, running diagnostics which are appropriate to the fault type. The service can validate a set of preconditions prior to taking remedial action. For example, the service can empirically validate that the network topology is actually as expected and that automatic remediation would be safe and would not compromise network availability or redundancy. Diagnostic information can be recorded in a trouble ticket to support post-event auditing. Once the preconditions have been validated, the service can automatically take corrective action based on the type of the fault, such as shutting down an interface on a particular network device.

Abstract: A damped hinge assembly includes a hinge arm adapted to be connected to an associated appliance body. A channel is pivotally connected to the hinge arm and is adapted to be connected to an associated appliance door. A damper is operatively connected between the channel and the hinge arm. The damper includes a body defining a bore and a piston slidably received in the bore. A rod is connected to the piston and projects outward from the bore. A damper fluid is contained in the bore and acts on the piston to dampen sliding movement of the piston in at least one direction in the bore. A spring is located in the bore and acts on the piston to bias the piston toward one end of the bore. An oven or other appliance includes at least one damped hinge assembly.

Abstract: A cable having a conducting member made from a nanostructure-based material, and a shielding layer made of nanostructure-based material. The shielding layer can be circumferentially situated about the conducting member so as to enhance conductivity along the conducting member. A coupling mechanism may be situated between the shielding layer and the conducting member so as to secure the shielding layer in its position on the conducting member. A method of making the cable is also disclosed.

Abstract: A damped hinge assembly includes a hinge arm adapted to be connected to an associated appliance body. A channel is pivotally connected to the hinge arm and is adapted to be connected to an associated appliance door. A damper is operatively connected between the channel and the hinge arm. The damper includes a body defining a bore and a piston slidably received in the bore. A rod is connected to the piston and projects outward from the bore. A damper fluid is contained in the bore and acts on the piston to dampen sliding movement of the piston in at least one direction in the bore. A spring is located in the bore and acts on the piston to bias the piston toward one end of the bore. An oven or other appliance includes at least one damped hinge assembly.

Abstract: A counterbalance assembly for an appliance hinge has a base including first and second spaced-apart side walls and a transverse face wall. A channel is located between the first and second side walls. First and second notch portions are respectively located in the first and second side walls. A rotating cam is supported on the base and has a camshaft that extends between the side walls and that is adapted for rotation about an axis of rotation, a first end located in the first notch portion and a second end located in the second notch portion. A biasing spring has an inner end engaged with the base and an outer end spaced from the base. A spring rod includes an outer end operatively coupled to the spring and an inner end operatively coupled to the lever. The lever also pivotally connects to the lobe of the cam. A damper assembly is connected to the base and having a piston which is moved between a first position and a second position by the lever contacting the piston.

Abstract: A cable having a conducting member made from a nanostructure-based material, and a shielding layer made of nanostructure-based material. The shielding layer can be circumferentially situated about the conducting member so as to enhance conductivity along the conducting member. A coupling mechanism may be situated between the shielding layer and the conducting member so as to secure the shielding layer in its position on the conducting member. A method of making the cable is also disclosed.

Abstract: A container for holding a sample of essential oils is disclosed. The container can be substantially flat and flexible. The container can also be formed to include an internal pocket for holding essential oil. In some implementations, the container may be combined with and inserted into a sleeve. The sleeve may act as a business card or other marketing material, which can be handed out to individuals interested in learning more about essential oils.

Abstract: A receptacle for an associated appliance hinge includes a receptacle base and a breakaway lever movably connected to the receptacle base. The breakaway lever includes a cam edge. A first mounting structure is connected to the receptacle base and adapted to be engaged by an associated hinge arm. A second mounting structure connected to the breakaway lever such that the second mounting structure is movable relative to the receptacle base. The second mounting structure is adapted to be engaged by the associated hinge arm. A breakaway latch is connected to the base and includes a cam follower engaged with the cam edge. The breakaway latch further includes a spring that biases the cam follower into abutment with the cam edge. The breakaway lever is selectively movable from a first position where the cam follower is engaged with a first location on the cam edge to a second position where the cam follower is engaged with a second location on the cam edge.

Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Embodiments of systems and methods are described for dynamically managing requests for computing capacity from a provider of computing resources. Illustratively, the computing resources may include program execution capabilities, data storage or management capabilities, network bandwidth, etc. The systems or methods automatically allocate computing resources for execution of one or more programs associated with the user. The systems and methods may enable the user to make changes to the allocated resources after execution of the one or more programs has started.

Abstract: A door closure device includes a pivot pin adapted to engage an associated appliance hinge, and a channel rotatably connected to the pivot pin and adapted to be connected to an associated appliance door. A cam is non-rotatably engaged with the pivot pin. The cam comprises a lobed edge including a closing portion. A spring rod is slidably engaged with the channel, and a cam follower is operably engaged with the spring rod. A spring is engaged between the spring rod and the channel and biases the cam follower into engagement with the lobed edge of the cam. The follower moves along the lobed edge of the cam when the channel is rotated relative to the cam and the spring induces a door-closing torque on the channel when the follower is engaged with the closing portion of the cam lobed edge.

Abstract: Embodiments of systems and methods are described for dynamically managing requests for computing capacity from a provider of computing resources. Illustratively, the computing resources may include program execution capabilities, data storage or management capabilities, network bandwidth, etc. The systems or methods automatically allocate computing resources for execution of one or more programs associated with the user. The systems and methods may enable the user to make changes to the allocated resources after execution of the one or more programs has started.

Abstract: A method of modifying a hand-held tool which having a stationary handle actuated by a movable handle connected to a movable tool jaw by a connection linkage, the method including removing the moving handle and the stationary handle. A pneumatic actuator with a piston rod is added. The connection linkage is modified to extend between the piston rod and the movable tool jaw. A trigger is added between the pneumatic actuator and a source of pressurized gas.

Abstract: A system implementing a situation-oriented directory for retrieving a stakeholder identification includes a memory storing a relational database corresponding to the situation-oriented directory including a plurality of attribute-value combinations and a plurality of stakeholder identifications, wherein the plurality of attribute-value combinations are mapped to the plurality of stakeholder identifications such that for each attribute-value combination exactly one stakeholder is mapped, and a processor in communication with the memory for receiving a query and retrieving the stakeholder identification from among the plurality of stakeholder identifications based on the attribute-value combinations.

Abstract: One method of fabricating hybrid conductors includes complexing conductive metal elements (e.g., silver, gold, copper), transition metal elements, alloys, wires, or combinations thereof, with carbon nanotube materials. In the alternative, the hybrid conductors may be formed by doping the carbon nanotube materials in salt solutions.

Abstract: A vibratory roller is provided with an exciter assembly that need not be lubricated by an oil bath because the exciter gears need not be lubricated. At least an outer ring portion of at least one gear of the exciter assembly is formed from a non-metallic material. In one embodiment, a first gear is a composite gear having an outer toothed ring portion formed from a machined nylon material imbedded with at least one of a heat stabilizer and a lubricant, and a second, mating gear is formed from metal and acts as heat sink for the first gear. In another embodiment, both the first and second gears are composite gears having an outer toothed ring formed from a robust and thermally stable molded polymer. The gears can survive when the roller is operated at least 8 hours at a duty cycle of at least 50% while operating the roller at an ambient temperature of over 38° C. (100° F.) and while the exciter shaft is driven at a velocity of over 2,000 RPM and the exciter housing is subjected to over 31.

Abstract: A vibratory roller is provided with an exciter assembly that need not be lubricated by an oil bath because the exciter gears need not be lubricated. At least an outer ring portion of at least one gear of the exciter assembly is formed from a non-metallic material. In one embodiment, a first gear is a composite gear having an outer toothed ring portion formed from a machined nylon material imbedded with at least one of a heat stabilizer and a lubricant, and a second, mating gear is formed from metal and acts as heat sink for the first gear. In another embodiment, both the first and second gears are composite gears having an outer toothed ring formed from a robust and thermally stable molded polymer. The gears can survive when the roller is operated at least 8 hours at a duty cycle of at least 50% while operating the roller at an ambient temperature of over 38° C. (100° F.) and while the exciter shaft is driven at a velocity of over 2,000 RPM and the exciter housing is subjected to over 31.

Abstract: The exemplary embodiments include a radio frequency antenna switch configured to reject harmonic frequencies. In addition, the harmonic-rejected radio frequencies of the radio frequency antenna switch may be tuned by use of a capacitor array. The capacitor array may be configured with fuse elements or by control logic.

Abstract: Methods and apparatus are provided for encoding a work item type definition. In one embodiment, a method is provided for encoding the work item type definition as a data object, such as an XML document. The work item type definition may include a specification of workflow associated with the work item type, and//or a specification of the display of the work item type by a graphical user interface, such as that which may be provided by a workflow management application.