Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Dual-latch mechanisms are provided that allow two (or more) latches to be simultaneously released in response to a single input received via an actuator. Also disclosed are multiple-actuator systems with common locking elements that may simultaneously lock and unlock the multiple actuators via an input or inputs provided at a centralized location.

Abstract: An applicating machine for applying a flexible carrier to a plurality of containers provided from an infeed includes an orienter for placing containers into a correct rotational position and a transfer device for transferring the oriented containers in a fixed rotational position to a jaw drum for applying a flexible carrier to a plurality of containers provided.

Abstract: A system and method for discouraging the in appropriate use of a mobile device including registering a mobile device with a monitoring application running on a system coupled with a network. A mobile device is linked with the monitoring application through the network. The operational status of the mobile device is monitored to detect if a change occurs in the operational status. A change in the operational status of the mobile device is reported to the monitoring program with time information and the status change is displayed in a graphical interface, and a notification message is sent to a system user. Beacons might also be implemented to advise a device user to disable a mobile device to be monitored.

Abstract: Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 ?M against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

Abstract: Substituted furanopyrimidine chemical entities of Formula (I): wherein Ra has any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by PDE1 activity or dopaminergic signaling; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including cardiovascular, renal, hematological, gastroenterological, liver, cancer, fertility, and metabolic disorders.

Abstract: A security device maintenance system is provided. The aspects include one or more processors configured to assess security data quality by conducting one or more tests that compare the security data to one or more predetermined thresholds, assign one or more anomaly indicators to security devices if the security data quality fails to meet the one or more predetermined thresholds, and generate an automated maintenance report for the one or more security devices including the one or more anomaly indicators. The aspects can also include periodically retrieving one or more security data from the one or more security devices, utilizing an artificial intelligence (AI) model to detect one or more anomalies, and generating one or more predictive maintenance suggestions.

Abstract: Systems and methods are provided for collecting and transmitting information associated with conditions in an environment around a device. The method includes: collecting, using at least one infrared (IR) camera, IR data of the environment around the device; collecting, using at least one gas sensor, gas concentration data of at least one gas; collecting, using at least one particulate matter detector, particulate matter concentrations in the environment around the device, wherein the at least one infrared camera, the at least one gas sensor and the at least one particulate matter detector forward their respective collected data to a radio; generating, using at least one solar panel, power for at least one of the at least one IR camera, the at least one gas sensor and the at least one particulate matter detector; and transmitting, using the radio, the collected data.

Abstract: A system for lung assist includes a fiber bundle section including a fiber bundle housing defining a fiber bundle compartment therein, and a fiber bundle within the fiber bundle compartment. The fiber bundle housing includes a first interface on a second end of the fiber bundle housing opposite a first end thereof. The system further includes a base section having a housing including a pressurizing section including a pressurizing compartment and an interface section. The interface section includes an extending section which extends from a lateral end of the pressurizing section. The interface section includes a second interface formed on the extending section, which includes a releasable seal member configured to form a releasable sealing connection with the first interface of the fiber bundle section. The base section housing and the fiber bundle housing are separate elements connected by a releasable, sealing connection between the first and second interfaces.

Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof. Further disclosed a method for treating a disease or condition mediated, at least in part, by NLRP3, the method comprising administering an effective amount of the pharmaceutical composition, to a subject in need thereof.

Abstract: An apparatus includes a housing, a lockout arm, and a spring, and is configured for use with a linear surgical stapler having a first stapler half with a frame and a clamp lever, and a second stapler half with a latch projection. The lockout arm is rotatable between a lockout position and a bypass position and is biased toward the lockout position by the spring. In the lockout position the lockout arm inhibits a proximal end of the clamp lever in a closed state from coupling with a proximal end of the frame. In the bypass position the lockout arm permits the proximal end of the clamp lever in the closed state to couple with the proximal end of the frame. The lockout arm transitions from the lockout position to the bypass position only when the latch projection is properly captured by the clamp lever in the closed state.

Abstract: Systems and methods for administering trade orders are described. An embodiment comprises receiving, from a first server operated by a first trader, a communication including a first trade order and one or more selection criteria, the first trade order including at least one of a specified instrument, a specified quantity, and a specified price; determining that a database of trade orders does not contain a trade order matching the first trade order; identifying a plurality of traders satisfying the selection criteria; sending, to a plurality of second servers, a query including at least one of the specified instrument, the specified quantity, and the specified price; receiving, from a one of the plurality of second servers operated on behalf of a second trader, a positive response to the query; and facilitating execution of a trade between the first trader and the second trader for the specified instrument at the specified price.

Abstract: Novel indication for adropin to prevent or treat vasospasm, brain injury, or cerebral edema.

Abstract: This invention relates to compositions and methods for modifying GLABRA2 (GL2) genes in Brassica plants. The invention further relates to Brassica plants and parts thereof having a phenotype of modified trichomes, a reduced number of trichomes, or no trichomes using the methods and compositions of the invention.

Abstract: The present disclosure relates to kits, compositions, or one or more methods of detecting an analyte-of-interest using one or more protein-oligonucleotide reporters of the present disclosure. For example, the present disclosure relates to a composition, including: a conjugate reaction product of: a signal emitting peptide or functional fragment thereof having a predetermined electrophilic residue; a linker characterized as a fused sterol or stanol ring system, having a nucleophilic group at a 3-position of an A-ring of a fused sterol or stanol ring system with beta or alpha stereochemistry; and an oligonucleotide having a 5? end and a 3? end, wherein the composition is characterized by one of 3? end or 5? end attached to the linker and one of 3? end or 5? end attached to a quencher, and wherein the linker is covalently linked to the predetermined electrophilic residue.

Abstract: A system for ongoing multifactor authentication is provided. The system includes a computer device including at least one processor in communication with at least one memory device. The at least one memory device includes computer instructions that cause the at least one processor to a) instruct a computer device to conduct a multifactor authentication of a user; calculate an authentication level for the user based upon the multifactor authentication of the user; b) continually monitor one or more actions of the user to determine additional authentication data; c) update the authentication level for the user based upon the additional authentication data; d) receive a request from the user to access a first content; e) access an authentication profile for the first content; f) compare the authentication profile to the updated authentication level for the user; and g) determine whether to grant access to the first content based upon the comparison.

Abstract: A system, method, and computer program product for generating a resulting image from a set of images is disclosed. The method comprises receiving an image set that includes a first image of a photographic scene based on a first set of sampling parameters and a second image of the photographic scene based on a second set of sampling parameters, and generating a resulting image based on the first image and the second image according to depth values in a selection depth map. Each distinct depth value in the selection depth map corresponds to a different image in the image set.

Abstract: A system for 5G radio access networks, that enables smart RF signal repeater devices to perform many of the functions of a 5G base station to extend millimeter wave coverage for 5G communication networks while reducing costs, increasing versatility and optimizing coverage for user devices (UEs). The devices may include outdoor network repeaters and indoor subscriber repeaters, and other mmWave network transmitter devices in a mmWave network. Different types of 5G wireless communication networks may be employed including Open Radio Access Network (O-RAN), and Next Gen Radio Access Network (NG-RAN).

Abstract: A fuel injector and a nozzle for a fuel injector is provided. The nozzle is fabricated from a hardened nozzle body blank. The hardened nozzle body blank is machined to leave a hard wear resistant layer on the exterior surface of nozzle body blank. The nozzle includes at least one spray hole that is formed through the hard wear resistant layer on the exterior surface of the nozzle body blank.

Abstract: A surgical stapler includes an elongate cartridge channel, an anvil assembly, a clamp member and a deflection sensor. The elongate cartridge channel includes a proximal frame portion and a distal jaw portion. The distal jaw portion is configured to releasably receive a staple cartridge. The anvil assembly includes an elongate anvil channel and an anvil insert. The elongate anvil channel includes a proximal frame portion and a distal jaw portion. The anvil insert is disposed at the distal jaw portion. The deflection sensor is associated with the anvil assembly and is configured to detect deflection of the anvil assembly to facilitate generation of a notification as a function of the detected deflection.