Patents by Inventor Brigitte Bathe

Brigitte Bathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180346946
    Abstract: The present invention relates to a method for producing L-methionine in which a microorganism is cultured in the presence of L-homoserine and methyl mercaptan, a salt of the same or dimethyl disulfide whereby the L-methionine is accumulated in the culture medium.
    Type: Application
    Filed: November 1, 2016
    Publication date: December 6, 2018
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Ines OCHROMBEL, Daniel FISCHER, Brigitte BATHE, Marleen HASSELMEYER, Michael HAMPEL, Joanne PEDALL
  • Patent number: 10077457
    Abstract: The present invention relates to a process for the fermentative production of L-amino acids using microorganisms of the Enterobacteriaceae family, which harbor an attenuated proP gene, to the microorganisms suitable for said production and to polynucleotides coding for variants of the ProP transporter.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 18, 2018
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Brigitte Bathe, Stella Molck, Horst Priefert
  • Publication number: 20170051324
    Abstract: It has been found, surprisingly, that the Corynebacterium humireducens strain comprises a very effective glycine cleavage system.
    Type: Application
    Filed: April 16, 2015
    Publication date: February 23, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Ines OCHROMBEL, Brigitte BATHE, Marleen HASSELMEYER
  • Publication number: 20170051323
    Abstract: Surprisingly, it has been found that alkaliphilic bacteria of the genus Corynebacterium are naturally suited to produce L-amino acids.
    Type: Application
    Filed: April 16, 2015
    Publication date: February 23, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Ines OCHROMBEL, Brigitte BATHE, Marleen HASSELMEYER, Jörn Kalinowski, Christian Rückert, Marcus Persicke
  • Patent number: 9562245
    Abstract: The invention relates to a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps: a) provision of a microorganism of the family Enterobacteriaceae or of a microorganism of the family Corynebacteriaceae which has an increased thiosulphate sulphurtransferase activity compared with the particular starting strain; b) fermentation of the microorganism, from a) in a medium which contains an inorganic source of sulphur chosen from the group of salt of dithiosulphuric acid or a mixture of a salt, of dithiosulphuric acid and a salt of sulphuric acid, a fermentation broth being obtained, and c) concentration of the sulphur-containing amino acid in the fermentation broth from b).
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 7, 2017
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Frank Schneider, Stella Molck, Brigitte Bathe
  • Publication number: 20160244490
    Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 25, 2016
    Applicant: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
  • Patent number: 9422568
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: August 23, 2016
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Nadja Jessberger, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Patent number: 9359413
    Abstract: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose from the medium; and to a method for the production of an organic-chemical compound, using the microorganism according to the invention, wherein accumulation of trehalose in the fermentation broth is reduced or avoided.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 7, 2016
    Assignee: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Alexander Reth, Wilfried Claes, Reinhard Krämer, Gerd Seibold, Alexander Henrich
  • Publication number: 20150353973
    Abstract: The present invention relates to a process for the fermentative production of L-amino acids using microorganisms of the Enterobacteriaceae family, which harbour an attenuated proP gene, to the microorganisms suitable for said production and to polynucleotides coding for variants of the ProP transporter.
    Type: Application
    Filed: July 31, 2013
    Publication date: December 10, 2015
    Inventors: Brigitte BATHE, Stella MOLCK, Horst PRIEFERT
  • Publication number: 20150322469
    Abstract: The invention relates to a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps: a) provision of a microorganism of the family Enterobacteriaceae or of a microorganism of the family Corynebacteriaceae which has an increased thiosulphate sulphurtransferase activity compared with the particular starting strain; b) fermentation of the microorganism, from a) in a medium which contains an inorganic source of sulphur chosen from the group of salt of dithiosulphuric acid or a mixture of a salt, of dithiosulphuric acid and a salt of sulphuric acid, a fermentation broth being obtained, and c) concentration of the sulphur-containing amino acid in the fermentation broth from b).
    Type: Application
    Filed: May 14, 2015
    Publication date: November 12, 2015
    Applicant: Evonik Degussa GMBH
    Inventors: Frank SCHNEIDER, Stella Molck, Brigitte Bathe
  • Patent number: 9163268
    Abstract: The invention relates to a method for preparing organic-chemical compounds, characterized in that the following steps are carried out: a) fermentation of a microorganism secreting an L-amino acid, which microorganism contains an overexpressed polynucleotide coding for a polypeptide having polyphosphate-dependent NAD+ kinase activity, in a fermentation medium, to form a fermentation broth, b) accumulation of said compound in said fermentation broth and/or in the cells of said microorganism. The invention relates to a method for preparing organic-chemical compounds by fermentation of a microorganism in which a polypeptide having polyphosphate-dependent NAD+ kinase is overexpressed.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: October 20, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Volker F. Wendisch, Steffen Lindner, Brigitte Bathe, Wilfried Claes
  • Patent number: 9074229
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 7, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Patent number: 9062332
    Abstract: Disclosed herein is a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps: a) provision of a microorganism of the family Enterobacteriaceae or of a microorganism of the family Corynebacteriaceae which has an increased thiosulphate sulphurtransferase activity compared with the particular starting strain; b) fermentation of the microorganism from a) in a medium which contains an inorganic source of sulphur chosen from the group of salt of dithiosulphuric acid or a mixture of a salt of dithiosulphuric acid and a salt of sulphuric acid, a fermentation broth being obtained, and c) concentration of the sulphur-containing amino acid in the fermentation broth from b).
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: June 23, 2015
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Frank Schneider, Stella Molck, Brigitte Bathe
  • Patent number: 9045762
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 2, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Publication number: 20150140614
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 21, 2015
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: ALEXANDER RETH, BRIGITTE BATHE, STEPHAN HANS, WILFRIED CLAES
  • Publication number: 20150056666
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Application
    Filed: November 4, 2014
    Publication date: February 26, 2015
    Applicant: Evonik Degussa GmbH
    Inventors: Alexander RETH, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Patent number: 8912313
    Abstract: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: December 16, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Alexander Reth, Brigitte Bathe, Stephan Hans, Wilfried Claes
  • Publication number: 20140127787
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Application
    Filed: October 22, 2013
    Publication date: May 8, 2014
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Nadja JESSBERGER, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Patent number: 8697850
    Abstract: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: April 15, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Nadja Jessberger, Andreas Burkovski, Brigitte Bathe, Alexander Reth
  • Patent number: 8637295
    Abstract: The invention relates to mutants of coryneform bacteria in which genes have been enhanced by the use of a mutated promoter region, and to processes for the production of amino acids using bacteria according to the invention.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: January 28, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Wilfried Claes, Brigitte Bathe