Patents by Inventor Brigitte Bathe

Brigitte Bathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequences coding for the LuxR gene
    Patent number: 7173105
    Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: February 6, 2007
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
  • Coryneform bacteria which produce chemical compounds I
    Patent number: 7160711
    Abstract: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: January 9, 2007
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach
  • Process for the production of L-amino acids by fermentation using coryneform bacteria
    Patent number: 7144724
    Abstract: A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: December 5, 2006
    Assignee: Degussa AG
    Inventors: Mike Farwick, Brigitte Bathe, Thomas Hermann, Achim Marx, Walter Pfefferle
  • Method for producing L-lysine or L-lysine containing feed additives with a cornebacteria containing a mutated lysC
    Patent number: 7135313
    Abstract: Alleles of the lysC gene from corynebacteria that code for desensitized aspartokinases, and to processes for the preparation of L-lysine using bacteria containing these alleles.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: November 14, 2006
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Stephen Hans
  • Nucleotide sequence encoding corynebacterium glutamicum leucine response regulatory protein
    Patent number: 7132272
    Abstract: The present invention relates to an isolated polynucleotide coding for the lrp gene and to a process for the fermentative production of L-amino acids by altering the expression of this gene.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: November 7, 2006
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Jörn Kalinowski, Alfred Pühler, Bettina Möckel, Walter Pfefferle
  • Alleles of the gnd gene from coryneform bacteria
    Publication number: 20060246554
    Abstract: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
    Type: Application
    Filed: September 16, 2005
    Publication date: November 2, 2006
    Applicant: Degussa AG
    Inventors: Georg Thierbach, Brigitte Bathe, Natalie Schischka
  • Nucleotide sequences coding for the citE gene
    Patent number: 7129066
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 31, 2006
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Brigitte Bathe, Walter Pfefferle
  • Nucleotide sequences which code for the eno gene
    Patent number: 7118904
    Abstract: The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids using coryneform bacteria.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 10, 2006
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Walter Pfefferle, Thomas Hermann, Alfred Pühler, Jörn Kalinowski, Brigitte Bathe
  • NUCLEOTIDE SEQUENCES WHICH CODE FOR THE ZWA1 GENE
    Publication number: 20060205046
    Abstract: Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
    Type: Application
    Filed: May 22, 2006
    Publication date: September 14, 2006
    Inventors: Bettina Mockel, Walter Pfefferle, Achim Marx, Jorn Kalinowski, Brigitte Bathe, Alfred Puhler
  • Nucleotide sequences coding for the pknB gene
    Patent number: 7105302
    Abstract: An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: September 12, 2006
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Mike Farwick, Thomas Hermann
  • Nucleotide sequences which code for the dep34 gene
    Publication number: 20060177912
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dep34 gene, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: November 16, 2005
    Publication date: August 10, 2006
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Thomas Hermann, Brigitte Bathe
  • Alleles of the aceA gene from coryneform bacteria
    Patent number: 7083942
    Abstract: The invention relates to alleles of the aceA gene from coryneform bacteria coding for isocitrate lyases and processes for the fermentative production of L-lysine using bacteria that contain these alleles.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: August 1, 2006
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Caroline Kreutzer, Stephan Hans
  • Alleles of the mqo gene from coryneform bacteria
    Publication number: 20060166338
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 27, 2006
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Polynucleotide sequences which encode the zwa1 gene
    Patent number: 7074607
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: July 11, 2006
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Walter Pfefferle, Achim Marx, Jörn Kalinowski, Brigitte Bathe, Alfred Pühler
  • Nucleotide sequences coding for the LuxR gene
    Publication number: 20060134761
    Abstract: The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.
    Type: Application
    Filed: December 27, 2004
    Publication date: June 22, 2006
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Caroline Kreutzer, Brigitte Bathe
  • Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene
    Patent number: 7049106
    Abstract: A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: May 23, 2006
    Assignee: Degussa AG
    Inventors: Mike Farwick, Brigitte Bathe, Thomas Hermann, Achim Marx, Walter Pfefferle
  • Methods for producing amino acids in coryneform bacteria using an enhanced sigC gene
    Patent number: 7037689
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigC gene from Corynebacterium glutamicum, and a host-vector system having a coryneform host bacterium, such as Corynebacterium glutamicum, and a vector which carries at least the sigC gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: May 2, 2006
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Mike Farwick, Thomas Hermann, Walter Pfefferle
  • Nucleotide sequences coding for the Dep33 efflux protein
    Patent number: 7038034
    Abstract: The invention provides nucleotide sequences from Coryneform bacteria coding for the dep33 efflux protein and a process for the fermentative preparation of amino acids using bacteria in which the dep33 efflux protein is attenuated.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: May 2, 2006
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Thomas Hermann, Brigitte Bathe
  • Nucleotide sequences which code for the dep34 gene
    Patent number: 7029904
    Abstract: The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the dep34 efflux protein, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: April 18, 2006
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Thomas Hermann, Brigitte Bathe
  • Process for the production of L-amino acids by fermentation using coryneform bacteria
    Publication number: 20060040317
    Abstract: The invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the mqo gene is attenuated, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and, optionally, bacteria are used in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally enhanced, or bacteria are used in which at least some of the metabolic pathways reducing formation of the desired L-amino acid are excluded.
    Type: Application
    Filed: November 2, 2005
    Publication date: February 23, 2006
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Brigitte Bathe, Thomas Hermann, Achim Marx, Walter Pfefferle