Patents by Inventor Bruce A. Freeman

Bruce A. Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fatty acids as anti-inflammatory agents
    Patent number: 9750725
    Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 5, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • Nitrated-fatty acids modulation of type II diabetes
    Patent number: 9700534
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: July 11, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • NITRATED LIPIDS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20170119717
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 4, 2017
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9522156
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: December 20, 2016
    Assignees: The UAB Research Foundation, The State of Oregon Acting by and through the State Board of Higher Education on Behalf of the University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • NITRATED LIPIDS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20160151391
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 2, 2016
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9295678
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: March 29, 2016
    Assignees: The UAB Research Foundation, The State of Oregon Acting By And Through The State Board Of Higher Education On Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES
    Publication number: 20160045467
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Application
    Filed: October 26, 2015
    Publication date: February 18, 2016
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • Nitrated-fatty acids modulation of type II diabetes
    Patent number: 9186408
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: November 17, 2015
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20150306074
    Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
    Type: Application
    Filed: May 20, 2015
    Publication date: October 29, 2015
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • NITRATED LIPIDS AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20150246059
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 3, 2015
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Fatty acids as anti-inflammatory agents
    Patent number: 9066902
    Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 30, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9006473
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: April 14, 2015
    Assignees: The UAB Research Foundation, The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20150018417
    Abstract: A class of enzymatically generated electrophilic fatty acid derivatives (EFADs), or their enzymatically generated metabolites. The EFAD's and their metabolites have beneficial effects human health. According to the inventors the inventive keto fatty acids or their enzymatically generated metabolites, can inhibit inflammation by giving rise to adaptive signaling molecules in vivo.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 15, 2015
    Inventors: Bruce A. Freeman, Francisco J. Schopfer
  • NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES
    Publication number: 20140309303
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 16, 2014
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: Bruce A. Freeman
  • Nitrated-fatty acids modulation of type II diabetes
    Patent number: 8735449
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: May 27, 2014
    Inventor: Bruce A. Freeman
  • Nitrated Lipids and Methods of Making and Using Thereof
    Publication number: 20130210917
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Application
    Filed: October 8, 2012
    Publication date: August 15, 2013
    Applicants: THE UAB RESEARCH FOUNDATION, Morehouse School of Medicine, Inc., University College Cardiff Consultants Limited, State of Oregon Acting By and Through the Board of Education on Behalf of the University of Oregon
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • VINYL SUBSTITUTED FATTY ACIDS
    Publication number: 20130012583
    Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 10, 2013
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, COMPLEXA, INC.
    Inventors: Bruce A. FREEMAN, Bruce BRANCHAUD
  • Nitrated-fatty acids modulation of type II diabetes
    Patent number: 8324277
    Abstract: Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-?.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: December 4, 2012
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Bruce A. Freeman
  • Nitrated lipids and methods of making and using thereof
    Patent number: 8309526
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: November 13, 2012
    Assignees: The UAB Research Foundation, University College Cardiff Consultants Ltd, Morehouse School of Medicine, University of Oregon
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20120136034
    Abstract: Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra?, Rb, Rb?, Rc, and Rc? are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
    Type: Application
    Filed: August 2, 2010
    Publication date: May 31, 2012
    Applicant: University of Pittsburgh -Of the Commonwealth Syst
    Inventors: Bruce A. Freeman, Francisco J. Schopfer