Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.

Abstract: A method and a system for accurately calculating the timing margin in a clock and data recovery system (CDR) is provided that utilizes a singular path environment of hardware. The method entails adding an amount of jitter within the CDR to change the receiver phase. The amount of jitter is incrementally increased until a threshold level of bit errors occur. Based on the amount of jitter needed to cause the threshold level of bit errors, timing margin can be calculated.

Abstract: A thermally actuated shutdown seal for a rotating shaft having a narrow annular fluid flow path surrounding the shaft. The seal surrounds the shaft with the annulus therebetween during normal operation and constricts against the shaft when the shaft slows or stops rotating. The annulus is maintained open during normal operation by a spacer interposed between opposing ends of a split ring. When the shaft stops rotating, the temperature of the annulus rises, which actuates removal of the spacer from the split ring constricting the split ring against the shaft blocking the annulus. The blocked annulus causes a pressure differential across the seal which urges a polymer seal ring, downstream of the split ring against the shaft which seals the annulus. In one embodiment, the spacer is formed of a meltable material. In a second embodiment, the spacer is removed from the split ring by a thermally responsive actuator.

Abstract: The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or enhanced binding affinity for pathogen-associated molecular patterns (PAMPs) and/or damage-associated molecular patterns (DAMPs).

Abstract: An aircraft monitoring system comprising a computer system and a receiver for receiving tracking data from a tracking device associated with an aircraft, the monitoring system having a passive tracking mode in which the computer system is configured to receive tracking data and an active tracking mode in which the computer system is configured to determine a condition indicative of an aircraft incident based on the absence of received tracking data. The monitoring system is automatically triggered into the active tracking mode when a signal is received from the aircraft indicating the aircraft has taken-off.

Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.

Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.

Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.

Abstract: The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.

Abstract: A thermally actuated shutdown seal for a rotating shaft having a narrow annular fluid flow path surrounding the shaft. The seal surrounds the shaft with the annulus therebetween during normal operation and constricts against the shaft when the shaft slows or stops rotating. The annulus is maintained open during normal operation by a spacer interposed between opposing ends of a split ring. When the shaft stops rotating, the temperature of the annulus rises, which actuates removal of the spacer from the split ring constricting the split ring against the shaft blocking the annulus. The blocked annulus causes a pressure differential across the seal which urges a polymer seal ring, downstream of the split ring against the shaft which seals the annulus. In one embodiment, the spacer is formed of a meltable material. In a second embodiment, the spacer is removed from the split ring by a thermally responsive actuator.

Abstract: A system for reducing waste and encouraging recycling through a vending system which refills only those containers which are compatible with the vending system. The vending system distinguishes a container's compatibility with the vending system to permit refilling of the container.

Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.

Abstract: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter of 1 ?m or smaller and in which the ratio of the total weight of the polymer and oil to the weight of the specific substance is 1.5 or higher.

Abstract: A small, lightweight housing includes a plurality of light signal transmitters and can be attached to the body such as the wrist of an operator such that another part of the body or another object can be brought into the beam of a particular light transmitter to reflect or scatter the light signal from one of the light signal transmitters and coded such that a particular light transmitter can be distinguished. A receptor associated with the housing receives the reflected or scattered or scattered light and alters the signal applied to a light signal transmitter, such as by increase of power, increase of the number of similarly modulated light transmitters which are driven or coding such as imposition of additional modulation. A signal is then received from an optical link by an optical receptor at a base station.

Abstract: A thermally actuated shutdown seal provides a shutdown seal usable in a pump having a primary seal assembly positioned circumferentially about a rotating shaft for separating a region of high pressure coolant fluid from the shaft. The shutdown seal includes a two-piece interlocked housing which encompasses carbon graphite ring segments positioned circumferentially about the shaft, a garter spring and a series of compression springs. The replaceable insert with machined recess contains the shutdown seal assembly and is biased axially with a wave spring and held with the annular recess by a closure ring. The seal is designed with coolant fluid flow directly in contact with such ring segments and specially designed paths around the ring segments during normal pump operation.

Abstract: A method and apparatus for measuring the bore diameter of a hole as a function of hole depth is disclosed. In one embodiment, the apparatus comprises a diametric probe, for generating first measured bore diameter data along a diametric probe sensitive axis; a foot, for positioning the diametric probe sensitive axis in a plane parallel to the hole; a linear distance probe, coupled to the diametric probe, for generating first measured depth data describing the depth of the diametric probe sensitive axis within the hole; and a data acquisition system, for recording first measured bore diameter data from the diametric probe and first measured depth data from the linear distance probe of an insertion of the diametric probe into the hole.

Abstract: The present invention provides a method for improving the stability of a bone-connecting implant in a human by administering PTH. A kit comprising an informational label and a composition of PTH and a buffer in one or more containers is also provided.

Abstract: A small, lightweight housing includes a plurality of light signal transmitters and can be attached to the body such as the wrist of an operator such that another part of the body or another object can be brought into the beam of a particular light transmitter to reflect or scatter the light signal from one of the light signal transmitters and coded such that a particular light transmitter can be distinguished. A receptor associated with the housing receives the reflected or scattered or scattered light and alters the signal applied to a light signal transmitter, such as by increase of power, increase of the number of similarly modulated light transmitters which are driven or coding such as imposition of additional modulation. A signal is then received from an optical link by an optical receptor at a base station.

Abstract: A wireless control device includes a small, lightweight housing worn by an operator, for example on the operator's wrist, and a controlled device, for example a personal computer. Several optical emitters, preferably light emitting diodes operating in the infrared range, and several optical detectors are provided on the housing. At least one x-axis emitter-detector pair operates to detect an x-direction of a pointing motion or gesture, and at least one y-axis emitter-detector pair operates to detect a y-direction of a pointing motion or gesture. This motion can then be used to cause a response in the controlled device. For example, angles of the operator's hand at the wrist can be interpreted to induce motion of a cursor on a computer display. The device may also include a motion sensor, an environmental condition sensor, or a voice recognition sensor, and can also be adapted for gesture recognition and image scanning applications.

Abstract: Bulked continuous filament yarns comprise a plurality of substantially continuous filaments comprising propylene polymer and having recovery from compression, as measured by Plug Crush Recovery, of at least about 85%. The yarns exhibit improved resilience and are well suited as face yarns for residential, commercial and automotive carpets.