Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Abstract: A stimulation system for a nerve, including a cuff configured and arranged to be placed, at least partially, around the nerve, and a plurality of electrode contacts disposed on the cuff such that distances between a first electrode contact within the plurality of electrode contacts and each electrode contact immediately adjacent to the first electrode contact are different.

Abstract: An implantable stimulator, having at least one electrode contact array comprising multiple electrode contacts disposed on an external surface of said stimulator. The electrode contacts are configured to have a first polarity. At least one additional electrode contact is disposed on the external surface, the at least one additional electrode contact is configured to have a second polarity. One or more of the electrode contacts disposed on the stimulator are configured to deliver at least one or more of a monopolar stimulation and a multipolar stimulation.

Abstract: A stimulator arrangement for a nerve, having a cuff configured and arranged to be placed around the nerve. The cuff includes a first edge, and defines a plurality of indentations along the first edge of the cuff. A plurality of electrodes are disposed on the cuff.

Abstract: An electrode assembly for an implantable medical device, including a spine, and a plurality of electrodes protruding from the spine. At least two electrodes protrude from the spine in opposing directions and define a nerve-receiving channel. When the electrode assembly is not coupled to a nerve and the electrodes are in a relaxed state position, the nerve receiving channel comprises a cross-sectional area that is substantially less than a cross-sectional area of a nerve to which the electrode assembly is adapted to be coupled. And when coupled to the nerve, each electrode wraps around and directly contacts at least 60% of the circumference of the nerve.

Abstract: An implantable medical device, having a neural stimulator adapted to generate neural stimulation signals, an electrode configuration tester for testing a first electrode configuration for stimulating a desired neural target, and a controller. The controller is configured to control the neural stimulator to selectively provide a first neural stimulation signal with appropriate signal characteristics to stimulate the desired neural target using the first electrical configuration and a second neural stimulation signal with appropriate signal characteristics to stimulate the desired neural target using a second electrode configuration, and adapted to communicate with the electrode configuration tester and to respond to an indication that an efficacy of the first electrode configuration is lower than a threshold by providing the neural stimulation using the second neural stimulation signal.

Abstract: An apparatus capable of being implanted in a patient's body, including a posture sensor, a heart rate sensor, and a processor coupled to the posture sensor and the heart rate sensor. The processor is configured to measure the patient's heart rate via the cardiac signal sensor, detect a change in a posture of the patient's body via the posture sensor, and determine an autonomic tone of the patient's body based on the patient's heart rate measured during a time period corresponding to the change in posture.

Abstract: A system for stimulation, including an implantable pulse generator, a lead comprising an array body disposed at a distal end of the lead and a plurality of electrodes concentrically arranged on the array body, and a plurality of conductors, wherein one of the conductors is attached to each electrode and wherein the conductors are configured and arranged to couple the electrodes to the implantable pulse generator.

Abstract: A system for providing neural stimulation, including an activity monitor to sense activity and provide a signal indicative of the activity and a neural stimulator. The neural stimulator includes a pulse generator to provide a neural stimulation signal adapted to provide a neural stimulation therapy, and a modulator to receive the signal indicative of the activity and modulate the neural stimulation signal based on the signal indicative of the activity to change the neural stimulation therapy.

Abstract: The present invention is a method for stimulating living tissue with an electrical neurostimulator, by maintaining a plurality of stimulation sets of stimulation parameters with each set of stimulation parameters defining at least a pulse characteristic and an electrode configuration in memory of the neurostimulator. Further, a repetition parameter for at least one of the plurality of stimulation sets in memory of the neurostimulator is maintained, wherein the repetition parameter identifies a number of times that a pulse is to be repeated in a consecutive manner for the at least one stimulation set. Also, living tissue is stimulated using a substantially continuous set of pulses wherein the stimulating includes selecting a stimulation set, generating a pulse according to the pulse characteristic of the selected stimulation set, and delivering the generated pulse to living tissue through electrodes according to the electrode configuration of the selected stimulation set.

Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohornonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. A mapping method permits the baroreceptor activation device to be precisely located to maximize therapeutic efficacy.

Abstract: Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal.

Abstract: Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.