Abstract: A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.

Abstract: An anti-tussive nebulized solution for targeted delivery of lidocaine into conducting and central airways. A method for treatment of cough and tussive attacks or episodes using said lidocaine solution. A nebulized lidocaine solution administered in daily dose from about 10 mg to 80 mg of lidocaine dissolved in a saline and nebulized into an aerosol having a mass median aerodynamic diameter 3 ?m to 10 ?m and a geometric standard deviation less than 1.7 using an electronic nebulizer.

Abstract: A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.

Abstract: A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.

Abstract: The invention disclosed herein represents a means for increasing the gripability of a credit-card-sized card. Specifically, dimples raised from, indented in, or embossed in a credit-card-sized card are arranged to from a tread on the front or back of a card. This tread allows fingers to more easily grip a credit-card-sized card for ease of handling or removal from a wallet or carrying case. Moreover, the means disclosed does not interfere with various means such as magnetic stripes commonly used to store encoded information on credit-card-sized cards.

Abstract: Antenna assemblies and corresponding modes of operation are provided where the first antenna assembly of the system is tuned to a first frequency band v1 and the second antenna assembly of the antenna system is tuned to a second frequency band v2. The ground plane of the first antenna assembly is configured as a frequency selective surface that is substantially reflective of radiation in the first frequency band and substantially transparent to radiation in the second frequency band. The second ground plane may also be configured as a frequency selective surface and may be reflective of radiation in the second frequency band. Any number of additional antenna arrays may be added so long as the outer arrays are transparent to the inner arrays.

Abstract: A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.

Abstract: A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam, or a pharmaceutically acceptable salt thereof, delivered as an aerosol or dry powder formulation.

Abstract: A process for manufacturing bulk solutions and lyophilized pure ?-aztreonam lysinate for large scale production of an inhalable aztreonam is disclosed, as is a pure ?-aztreonam lysinate for inhalation. A dry powder or lyophilized pure ?-aztreonam lysinate composition for inhalation is also disclosed.

Abstract: An improved apparatus and method for applying labels to documents, such as mail pieces is provided. According to one aspect, a method and apparatus are provided for applying labels to documents, wherein labels are serially peeled from a liner along the width of the liner and then transported toward a document by a label transport. The labels are conveyed along the transport so that a short side of the label is the leading edge. In addition a method and apparatus are provided wherein labels are applied by removing a first label from a web, conveying the label along a label path to a staging position and then conveying the label toward a document path where the label is adhered to a document.

Abstract: A method is provided for administering to a mammal suffering from, or at risk for, multiple sclerosis, an initial dosing of a therapeutically effective amount of an anti-LFA-1 antibody, followed by a subsequent intermittent dosing of a therapeutically effective amount of the anti-LFA-1 antibody wherein the antibody is administered to the mammal no more than once per week in the intermittent dosing.

Abstract: An ensemble clock comprises: an input for receiving a reference signal; multiple free-running oscillators each configured to generate a corresponding free-running frequency; an output oscillator configured to generate a controlled frequency having a frequency responsive to a control signal; a differencer unit configured to derive difference measurements indicative of time and frequency-based errors associated with each of (i) the controlled frequency, and (ii) the free-running frequency, relative to the reference signal; and a controller configured to generate the control signal responsive to the difference measurements.