Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is cross-reactive with a non-human primate CCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general.

Abstract: An apparatus is provided for a turbine engine. This turbine engine apparatus includes a journal bearing extending axially along and circumferentially about an axis. The journal bearing extends radially between an inner side and an outer side. The journal bearing includes a bore, a passage and a groove. The bore extends axially within the journal bearing and is formed by the inner side. The passage extends radially within the journal bearing and is fluidly coupled with the bore and the groove. The groove is arranged at the outer side. The groove extends longitudinally within the journal bearing between a first end and a second end. The groove extends axially within the journal bearing between a first side and a second side. An axial distance between the first side and the second side changes as the groove extends longitudinally between the first end and the second end.

Abstract: An apparatus is provided for a turbine engine. This turbine engine apparatus includes a journal bearing extending axially along and circumferentially about an axis. The journal bearing extends radially between a bearing inner side and a bearing outer side. The journal bearing includes a bore, a passage, a groove and a slot. The bore extends axially within the journal bearing and along the bearing inner side. The passage extends radially within the journal bearing and is fluidly coupled with the bore and the groove. The groove extends longitudinally within the journal bearing at the bearing outer side between a groove first end and a groove second end. At least a portion of the slot extends circumferentially about the axis within the journal bearing at the bearing outer side from the groove first end to the groove second end.

Abstract: A powerplant system is provided that includes a gas turbine engine system and an actuation system. The gas turbine engine system includes a rotating structure, a stationary structure and one or more bearings rotatably mounting the rotating structure to the stationary structure. The actuation system is configured to passively rotate the rotating structure about a rotational axis during transportation of the gas turbine engine system.

Abstract: A powerplant system is provided that includes a gas turbine engine system and an actuation system. The gas turbine engine system includes a rotating structure, a stationary structure and one or more bearings rotatably mounting the rotating structure to the stationary structure. The actuation system is configured to passively rotate the rotating structure about a rotational axis during transportation of the gas turbine engine system.

Abstract: The present invention is related to the field of detection of operational failures, more specifically with the monitoring of head loss in equipment such as reactors, heat exchangers and adsorption vessels. The invention uses a method for continuous monitoring of equipment head loss, in order to assist in the early identification and action on this type of problem, avoiding or reducing losses resulting from its occurrence.

Abstract: An assembly is provided for a turbine engine. This turbine engine assembly includes a journal bearing and a filter. The journal bearing has an internal bearing bore. The filter is arranged within the internal bearing bore. The filter includes a tubular filter element and a first end cap. The tubular filter element extends axially along an axis between a first end and a second end. A perforated portion of the tubular filter element is radially disposed away from the journal bearing by a cavity. The first end cap is mounted to the tubular filter element at the first end. The first end cap is sealed radially against the journal bearing by a first interference fit.

Abstract: An apparatus is provided for a turbine engine. This turbine engine apparatus includes a journal bearing extending axially along and circumferentially about an axis. The journal bearing extends radially between a bearing inner side and a bearing outer side. The journal bearing includes a bore, a passage, a groove and a slot. The bore extends axially within the journal bearing and along the bearing inner side. The passage extends radially within the journal bearing and is fluidly coupled with the bore and the groove. The groove extends longitudinally within the journal bearing at the bearing outer side between a groove first end and a groove second end. At least a portion of the slot extends circumferentially about the axis within the journal bearing at the bearing outer side from the groove first end to the groove second end.

Abstract: An assembly is provided for a turbine engine. This turbine engine assembly includes a journal bearing and a filter. The journal bearing has an internal bearing bore. The filter is arranged within the internal bearing bore. The filter includes a tubular filter element and a first end cap. The tubular filter element extends axially along an axis between a first end and a second end. A perforated portion of the tubular filter element is radially disposed away from the journal bearing by a cavity. The first end cap is mounted to the tubular filter element at the first end. The first end cap is sealed radially against the journal bearing by a first interference fit.

Abstract: An apparatus is provided for a turbine engine. This turbine engine apparatus includes a journal bearing extending axially along and circumferentially about an axis. The journal bearing extends radially between an inner side and an outer side. The journal bearing includes a bore, a passage and a groove. The bore extends axially within the journal bearing and is formed by the inner side. The passage extends radially within the journal bearing and is fluidly coupled with the bore and the groove. The groove is arranged at the outer side. The groove extends longitudinally within the journal bearing between a first end and a second end. The groove extends axially within the journal bearing between a first side and a second side. An axial distance between the first side and the second side changes as the groove extends longitudinally between the first end and the second end.

Abstract: The present invention addresses to obtaining a support of hydrorefining catalysts by an innovative preparation route that reduces the problem of loss (or leaching) of boron over the operating time of industrial units. As the presence of boron in catalysts contributes to increased activity (hydrogenating and acidic) and stability for the hydrorefining reactions (hydrotreating and hydrocracking), its maintenance in the catalyst guarantees the preservation of the properties in operation, throughout the entire cycle of campaign of industrial units.

Abstract: An active de-aerator for an aircraft engine is provided, with a housing having an air-oil inlet, an oil outlet and an air outlet. An impeller is received within and rotatable relative to the housing about a central axis. The active de-aerator has a first journal bearing on a first side of the impeller for rotatably supporting the impeller relative to the housing and a second journal bearing on a second side of the impeller for rotatably supporting the impeller relative to the housing, the second side being opposite the first side.

Abstract: An active de-aerator for an aircraft engine is provided, with a housing having an air-oil inlet, an oil outlet and an air outlet. An impeller is received within and rotatable relative to the housing about a central axis. The active de-aerator has a first journal bearing on a first side of the impeller for rotatably supporting the impeller relative to the housing and a second journal bearing on a second side of the impeller for rotatably supporting the impeller relative to the housing, the second side being opposite the first side.

Abstract: A journal bearing assembly for rotatably supporting a gear in a gear system. The journal bearing assembly comprises a journal bearing for rotatably supporting the at least one gear. The journal bearing includes an engagement feature at a distal end thereof. The distal end is insertable into an opening in a gear carrier of the gear system. The opening includes an anti-rotation feature engageable with the engagement feature to block the journal bearing from rotating about an axis extending longitudinally through the center of the journal bearing. The journal bearing assembly further includes a fastening feature for fastening the journal bearing to the gear carrier.

Abstract: A seal runner assembly for a gas turbine engine includes a non-rotational annular wear seal, and an annular seal runner having an annular body defining an annular front face contacting the wear seal, the annular body defining an aperture extending axially through the seal runner, the aperture configured for receiving therein a part of a shaft of the gas turbine engine, the seal runner having a plurality of axially-extending slots at locations that are distributed around a wall of the seal runner that extends circumferentially about at least a portion of the annular front face and extends from the front face in a direction away from the wear seal. A method for sealing a gap between a part of a machine and a rotatable shaft of the machine is also provided.

Abstract: A journal bearing assembly for rotatably supporting a gear in a gear system. The journal bearing assembly comprises a journal bearing for rotatably supporting the at least one gear. The journal bearing includes an engagement feature at a distal end thereof. The distal end is insertable into an opening in a gear carrier of the gear system. The opening includes an anti-rotation feature engageable with the engagement feature to block the journal bearing from rotating about an axis extending longitudinally through the center of the journal bearing. The journal bearing assembly further includes a fastening feature for fastening the journal bearing to the gear carrier.

Abstract: Methods of treating a hepatitis delta virus (HDV) infection in a human patient are provided. In some embodiments, the method comprising administering to the patient a therapeutically effective amount of interferon lambda for at least four weeks.

Abstract: Methods of treating a hepatitis delta virus (HDV) infection in a human subject are provided. In some embodiments, the method comprises subcutaneously administering to the subject a therapeutically effective amount of pegylated interferon lambda-1a for at least 48 weeks.

Abstract: A seal runner assembly for a gas turbine engine includes a non-rotational annular wear seal, and an annular seal runner having an annular body defining an annular front face contacting the wear seal, the annular body defining an aperture extending axially through the seal runner, the aperture configured for receiving therein a part of a shaft of the gas turbine engine, the seal runner having a plurality of axially-extending slots at locations that are distributed around a wall of the seal runner that extends circumferentially about at least a portion of the annular front face and extends from the front face in a direction away from the wear seal. A method for sealing a gap between a part of a machine and a rotatable shaft of the machine is also provided.

Abstract: Methods of treating a hepatitis delta virus (HDV) infection in a human patient are provided. In some embodiments, the method comprising administering to the patient a therapeutically effective amount of interferon lambda for at least four weeks.