Patents by Inventor Bryan Crane
Bryan Crane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938479Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: GrantFiled: May 8, 2023Date of Patent: March 26, 2024Assignee: ILLUMINA, INC.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Publication number: 20240003929Abstract: Non-contact dispensers and related systems and methods are disclosed. In accordance with an implementation, an apparatus includes a non-contact dispenser includes a body defining an inlet, an outlet, and a flow path fluidly coupling the inlet and the outlet. The non-contact dispenser also includes a first valve to control flow into a portion of the flow path, a second valve to control flow out of the outlet, and a pump positioned between the first valve and the second valve.Type: ApplicationFiled: June 28, 2023Publication date: January 4, 2024Inventor: Bryan Crane
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Publication number: 20230418039Abstract: Substrates for performing quantification processes and related systems and methods are disclosed. In an implementation, an apparatus includes a substrate and an imaging system. The substrate includes a pair of plates and a plurality of spacers positioned between the plates to define a gap between the pair of plates. A portion of a sample is to be received within the gap of the substrate and the imaging system is to obtain image data of the portion of the sample. The image data is to be used to determine a concentration of the portion of the sample.Type: ApplicationFiled: June 27, 2023Publication date: December 28, 2023Inventor: Bryan Crane
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Publication number: 20230313178Abstract: Library preparation systems and methods are disclosed. An apparatus includes a plate receptacle, a magnet, a thermocycler, and an actuator. The plate receptacle is to receive a plate having a well and the thermocycler is to adjust a temperature of a sample within the well of the plate and the actuator is to move the magnet relative to the plate receptacle.Type: ApplicationFiled: March 27, 2023Publication date: October 5, 2023Inventor: Bryan Crane
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Publication number: 20230311119Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: ApplicationFiled: May 8, 2023Publication date: October 5, 2023Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Patent number: 11697116Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: GrantFiled: April 5, 2022Date of Patent: July 11, 2023Assignee: ILLUMINA, INC.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Publication number: 20230137970Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: ApplicationFiled: December 29, 2022Publication date: May 4, 2023Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Publication number: 20230031325Abstract: Actuation systems and methods for use with flow cells. In accordance with an implementation, a method includes moving, using an actuator disposed within a manifold assembly, a membrane portion of a membrane of the manifold assembly away from a valve seat to enable fluidic flow from a reagent fluidic line to a common fluidic line. The membrane portion and the valve seat forming a membrane valve. The reagent fluidic line being fluidically coupled to a reagent reservoir. The common fluidic line being fluidically coupled to a flow cell. The common fluidic line has a common central axis and the reagent fluidic line has a reagent central axis that is non-collinear with the common central axis. The method includes urging the membrane portion against the valve seat to prevent fluidic flow from the reagent fluidic line to the common fluidic line.Type: ApplicationFiled: December 18, 2020Publication date: February 2, 2023Inventors: Paul Crivelli, Cyril Delattre, Gerald Kreindl, Wesley A. Cox-Muranami, Bryan Crane
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Patent number: 11565267Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: GrantFiled: January 6, 2020Date of Patent: January 31, 2023Assignee: Illumina, Inc.Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Patent number: 11559805Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: GrantFiled: January 23, 2019Date of Patent: January 24, 2023Assignee: ILLUMINA, INC.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Publication number: 20220226819Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: ApplicationFiled: April 5, 2022Publication date: July 21, 2022Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark Reed
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Patent number: 11117130Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: GrantFiled: May 14, 2020Date of Patent: September 14, 2021Assignee: ILLUMINA, INC.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark Reed
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Publication number: 20200290043Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: ApplicationFiled: May 14, 2020Publication date: September 17, 2020Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark Reed
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Publication number: 20200139375Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: ApplicationFiled: January 6, 2020Publication date: May 7, 2020Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Patent number: 10549281Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: GrantFiled: May 12, 2017Date of Patent: February 4, 2020Assignee: ILLUMINA, INC.Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Publication number: 20190151845Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: ApplicationFiled: January 23, 2019Publication date: May 23, 2019Applicant: Illumina, Inc.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Patent number: 10220386Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.Type: GrantFiled: November 22, 2014Date of Patent: March 5, 2019Assignee: ILLUMINA, INC.Inventors: Erik Williamson, Bryan Crane, Patrick Leung, Drew Verkade, Mark T. Reed
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Systems and methods for integrating, unifying and displaying patient data across healthcare continua
Patent number: 10042979Abstract: Implementations are directed to providing a user of a mobile device access to patient information and patient physiological data. Actions can include receiving user input, the user input indicating a user command to display a laboratory results screen for a particular patient, processing patient-specific data and lab results data to provide one or more tables, and displaying the laboratory results screen on the mobile device, the laboratory results screen including the one or more tables, each table of the one or more tables providing one or more discrete data values, wherein a discrete data value of the one or more discrete values is user-selectable to provide detailed result information.Type: GrantFiled: February 28, 2014Date of Patent: August 7, 2018Assignee: AirStrip IP Holdings, LLCInventors: Stephen Trey Moore, Augustine Vidal Pedraza, IV, Neil R. McQueen, Lloyd Kory Brown, Thomas Scott Wade, William Bryan Crane, Jean-Francois Lancelot -
Publication number: 20170246635Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: ApplicationFiled: May 12, 2017Publication date: August 31, 2017Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Patent number: 9650669Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: GrantFiled: July 18, 2014Date of Patent: May 16, 2017Assignee: Illumina, Inc.Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe