Abstract: Various examples are directed to systems and methods for routing an autonomous vehicle. A vehicle autonomy system may generate first route data describing a first route for the autonomous vehicle to a first target location and control the autonomous vehicle using the first route data. The vehicle autonomy system may determine that the autonomous vehicle is within a threshold of the first target location and select a second target location associated with at least a second stopping location. The vehicle autonomy system may generate second route data describing a route extension of the first route from the first target location to the second target location and control the autonomous vehicle using the second route data.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: Exemplary embodiments provided herein include an intelligent secure networked health messaging system including a data retention system and a health analytics system, the health analytics system performing asynchronous processing with a user's computing device, a web services layer providing access to the data retention and the health analytics system, a batching service, wherein an application server layer transmits a request to the web services layer for data, the request processed by the batching service transparently to the user, the request processed by the batching service transparently to the user such that the user can continue to use a user-facing unity application without disruption, the application server layer including a high speed data corridor established between the application server layer and the user's computing device that provides the user-facing unity application that accesses the data retention and the health analytics system through the web services layer, and performs processing based

Abstract: The invention relates to multimeric fusion proteins which bind to human Fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: A pumping system pumps material downhole, for example, to perform a fracturing operation. The pumping system comprises one or more variable speed engines, one or more variable displacement hydraulic pumps and one or more intensifiers. According to the desired or required load, the speed of the engine is set at an optimal or most efficient operating speed. The volumetric displacement of the variable displacement hydraulic pump is set to provide the desired output volume and pressure of the material from the intensifier. Varying the speed of the engine and the volumetric displacement of the variable displacement pump allows for the pumping system and in particular the engine to operate at an optimal efficiency which reduces at least fuel costs and wear and tear on components.

Abstract: An autonomous vehicle (AV) includes a vehicle computing system including one or more processors programmed to receive map data associated with a map of a geographic location, determine, based on the map data, one or more local routes in the one or more roadways between the current location of the AV and one or more exit locations, and control travel of the AV based on a selected local route of the one or more local routes. The map includes one or more roadways in the geographic location. The map data includes a global route in the one or more roadways between a current location of the AV and a destination location of the AV. The one or more exit locations are located between the current location of the AV and the destination location of the AV.

Abstract: Systems and methods for monitoring movement capabilities using clinical mobility based assessments of a user are provided herein. In embodiments, methods include: providing, using a mobile device comprising an inertial measurement device, a clinical mobility based assessment to a user; and generating, using the inertial measurement device, inertial data of the user that is indicative of movement capabilities of the user based on the clinical mobility based assessment. Embodiments include logging the inertial data of the user locally to the mobile device resulting in locally logged inertial data of the user; processing in real-time the locally logged inertial data of the user to determine position and orientation of the mobile device during the clinical mobility based assessment; and determining, using the position and the orientation of the mobile device during the clinical mobility based assessment, a physical movement assessment of the user associated with the clinical mobility based assessment.

Abstract: An autonomous vehicle (AV) includes a vehicle computing system including one or more processors programmed to receive map data associated with a map of a geographic location, including, one or more local routes in the one or more roadways between the current location of the AV and one or more exit locations, receive sensor data associated with an object detected in an environment surrounding the AV, select a local route of the one or more local routes based on the sensor data and control travel of the AV based on a selected local route of the one or more local routes. The map includes one or more roadways in the geographic location. The one or more exit locations are located between the current location of the AV and the destination location of the AV in a global route in the one or more roadways.

Abstract: The present disclosure relates to a method of treating non-alcoholic steatohepatitis (NASH) comprising administering to a subject with NASH a combination therapy comprising semaglutide, firsocostat, and/or cilofexor.

Abstract: Systems and methods herein describe accessing a set of feature flags, a first feature flag in the set of feature flag describing vehicle navigation behavior on a routing graph, the routing graph representing the roadway, associating the set of feature flags with a vehicle, applying the associated set of feature flags to a graph traversal algorithm to generate a modified graph traversal algorithm, generating the route using the modified graph traversal algorithm; and transmitting instructions to the vehicle to begin executing the route.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: Systems and methods for monitoring movement capabilities using clinical mobility based assessments of a user are provided herein. In embodiments, methods include: providing, using a mobile device comprising an inertial measurement device, a clinical mobility based assessment to a user; and generating, using the inertial measurement device, inertial data of the user that is indicative of movement capabilities of the user based on the clinical mobility based assessment. Embodiments include logging the inertial data of the user locally to the mobile device resulting in locally logged inertial data of the user; processing in real-time the locally logged inertial data of the user to determine position and orientation of the mobile device during the clinical mobility based assessment; and determining, using the position and the orientation of the mobile device during the clinical mobility based assessment, a physical movement assessment of the user associated with the clinical mobility based assessment.

Abstract: In accordance with presently disclosed embodiments, systems and methods for sequencing portable containers of bulk material to provide continuous bulk material usage at an outlet are provided. The disclosed sequencing techniques may involve identifying a sequence for opening different portable containers of bulk material (or identifying the “next” portable container to open) and automatically actuating the discharge gates of the portable containers in the desired sequence to provide a continuous flow of bulk material to the outlet (e.g., blender unit). The identified sequence may be executed through a control system communicatively coupled to actuators used to open/close the discharge gates of the portable bulk material containers. A GUI may be communicatively coupled to the control system to allow an operator to select the desired sequence for execution by the control system and to display information regarding the portable bulk material containers.

Abstract: In accordance with presently disclosed embodiments, systems and methods for efficiently managing bulk material are provided. The disclosure is directed to systems and methods for efficiently combining additives into bulk material being transferred about a job site. The systems may include a support structure used to receive one or more portable containers of bulk material, and a mulling device disposed beneath the support structure to provide bulk material treatment capabilities. Specifically, the mulling device may facilitate mixing of coatings or other additives with bulk material that is released from the portable containers, as well as transfer of the mixture to an outlet location.

Abstract: Systems and methods for managing bulk material efficiently at a well site are provided. The disclosure is directed to a container support frame that is integrated into a blender unit. The support frame is used to receive one or more portable containers of bulk material, and the blender unit may include a gravity feed outlet for outputting bulk material from the containers directly into a mixer of the blender unit. The blender unit with integrated support frame may eliminate the need for any subsequent mechanical conveyance of the bulk material (e.g., via a separate mechanical conveying system or on-blender sand screws) from the containers to the mixer. As such, the integrated blender unit may be lighter weight, take up less space, and have a lower cost and complexity than existing blenders.

Abstract: In accordance with presently disclosed embodiments, systems and methods for using one or more pre-filled, portable containers, instead of pneumatic transfer, to move bulk material from a transportation unit to a blender receptacle of a blender are provided. A transportation unit may deliver one or more containers of bulk material to the well site, where the containers may be disposed in an elevated position around the blender receptacle. A gravity feed outlet may extend from one or more containers to route bulk material from the one or more containers directly into the blender receptacle. Since the transportation unit is able to unload the portable containers of bulk material without pneumatic transfer, the stackable containers may enable a cleaner and more efficient bulk material transfer at the site.

Abstract: A vehicle navigation system may include a data pipeline that proposes routing graph modifications from automatically ingested data sources and that provides enough context to suggest an expiration time to remove the routing graph modifications once imposed. The system and method receives from at least one data source routing graph modification data including geographic location data identifying a location to which a routing graph modification applies. The routing graph modification data is associated with one or more roadway elements in a routing graph of a navigation constraints system, and the routing graph modification data associated with the one or more roadway elements is classified as a routing graph modification. The routing graph modification is added to or, if expired, removed from the navigation constraints system.

Abstract: In accordance with presently disclosed embodiments, systems and methods for sequencing portable containers of bulk material to provide continuous bulk material usage at an outlet are provided. The disclosed sequencing techniques may involve identifying a sequence for opening different portable containers of bulk material (or identifying the “next” portable container to open) and automatically actuating the discharge gates of the portable containers in the desired sequence to provide a continuous flow of bulk material to the outlet (e.g., blender unit). The identified sequence may be executed through a control system communicatively coupled to actuators used to open/close the discharge gates of the portable bulk material containers. A GUI may be communicatively coupled to the control system to allow an operator to select the desired sequence for execution by the control system and to display information regarding the portable bulk material containers.

Abstract: Exemplary embodiments include an intelligent secure networked architecture configured by at least one processor to execute instructions stored in memory, the architecture comprising a data retention system and a machine learning system, a web services layer providing access to the data retention and machine learning systems, an application server layer that provides a user-facing application that accesses the data retention and machine learning systems through the web services layer and performs processing based on user interaction with an interactive graphical user interface provided by the user-facing application, the user-facing application configured to execute instructions for a method for room labeling for activity tracking and detection, the method including making a 2D sketch of a first room on an interactive graphical user interface, and using machine learning to turn the 2D sketch of the first room into a 3D model of the first room.