Abstract: Ladders and ladder components are provided including a rung assembly that provides an alert to a user of the ladder that they are standing on a particular rung or step. In one example, the lower most rung or step of a ladder includes a rung assembly having an alert mechanism. The alert mechanism may provide an audible and/or other sensory alert to a user when they step on the rung assembly so that the user recognizes their position relative to the ground or supporting surface. In one embodiment, the rung assembly is configured such that a front edge remains in a constant or fixed position relative to the rails to which it is coupled so that a user can rely on a fixed or constant position of the front edge of the assembly when climbing or descending the ladder.

Abstract: Surgical tool systems and methods of use thereof for performing endoscopic surgical procedures, which systems include a handpiece and a surgical accessory which detachably connects to the handpiece. The surgical accessory has a distal end which defines a cutting head incorporating two different types of tissue-treating areas.

Abstract: A semi-trailer aerodynamic drag deflection assembly for reducing aerodynamic drag upon all surfaces of the semi-trailer includes a pair of interior walls positioned against a respective one of a pair of lateral surfaces of a semi-trailer. A plurality of vents is positioned from an inner surface to an outer surface of the interior wall. A pair of exterior walls is positioned against a respective one of the pair of interior walls. An outside surface of each of the exterior walls has a plurality of indents for deflecting wind An undercarriage has a pair of side walls with a storage being positioned between each of the side walls. Each of the side walls has a plurality of fins directing aerodynamic drag from the bottom surface of the semi-trailer into each of the vents of each of the interior walls. A pair of doors provides access to the storage of the undercarriage.

Abstract: An air handling system for a hot air sterilizer apparatus includes a sterilization chamber having an air exhaust portal, an air handling pathway traversing above the sterilization chamber through an upper supply air plenum and traversing below the sterilization chamber through a lower supply air plenum, a circulation fan configured to direct supply air from the air exhaust portal over an upper heating element through the upper supply air plenum and over a lower heating element through the lower supply air plenum, a first temperature sensor in the upper supply air plenum and configured to measure temperature of air downstream from the upper heating element, a second temperature sensor in the lower supply air plenum and configured to measure temperature of air downstream from the lower heating element, and a third temperature sensor at the air exhaust portal and configured to monitor temperature of air exiting the sterilization chamber.

Abstract: An air duct includes a shell, a first annular chamber defined along a circumference of the sidewall and fluidly coupled with an inner volume defined by the shell through multiple first openings, a second annular chamber defined along the circumference of the shell at a longitudinal position downstream of the first annular chamber, and fluidly coupled with the inner volume of the shell through multiple second openings, a first pressure sensing coupler, a second pressure sensing coupler, a first field accessible coupler, and a second field accessible coupler. The first pressure sensing coupler is fluidly coupled with the first annular chamber and the second pressure sensing coupler is fluidly coupled with the second annular chamber for pressure detection. The first and second field accessible couplers are fluidly coupled with the first and second annular chambers for providing pressurized air to the first annular chamber and the second annular chamber.

Abstract: A technique for reading the columns and rows of a touch sensor provides several advantages, including scalability to touch sensors with high column/row counts. Reading the touch sensor relies on combining the row or column outputs of the touch sensor, during column and/or row excitation of the touch sensor, with the resulting combined signal or signals transformed into the frequency domain and touch detection based on evaluation of the frequency-domain values corresponding to the excitation frequencies.

Abstract: A display device includes a front portion, a rear portion, a halo, and sides extending between the front portion and the rear portion. The front portion, the rear portion, and the sides form an enclosure. The halo includes a rim and an internal structure. The rim is positioned between the front portion and the rear portion. The internal structure is at least partially within the enclosure and includes a sweep portion and a receiving post. The receiving post and the sweep portion are configured to receive light emitted by one or more light emitting devices and at least one of guide, direct, diffuse, focus, and scatter light emitted by the one or more light emitting devices out of the display device.

Abstract: Provided herein are Claudin 18.2 binding agents and chimeric antigen receptors (CARs) comprising a Claudin 18.2 binding molecule that specifically binds to Claudin 18.2; and immune cells comprising these Claudin 18.2-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using Claudin 18.2-specific CARs and Claudin 18.2 binding agents, and immune cells comprising Claudin 18.2-specific CARs.

Abstract: An air damper assembly for an air duct having an interior wall and an exterior wall is provided. The air damper assembly includes a damper plate having a periphery and multiple teeth spaced at least partially around and extending from the periphery. The multiple teeth vary in length from a maximum to a minimum over a span of approximately 90 degrees around the periphery. The air damper assembly further includes an axle assembly fixedly coupled to the damper plate and rotatably coupled to the air duct. Rotation of the axle assembly causes the damper plate to rotate within the air duct between a fully open position and a fully closed position to increase or decrease a flow of fluid through the air duct.

Abstract: A semi-trailer aerodynamic drag deflection assembly for reducing aerodynamic drag upon all surfaces of the semi-trailer includes a pair of interior walls positioned against a respective one of a pair of lateral surfaces of a semi-trailer. A plurality of vents is positioned from an inner surface to an outer surface of the interior wall. A pair of exterior walls is positioned against a respective one of the pair of interior walls. An outside surface of each of the exterior walls has a plurality of indents for deflecting wind An undercarriage has a pair of side walls with a storage being positioned between each of the side walls. Each of the side walls has a plurality of fins directing aerodynamic drag from the bottom surface of the semi-trailer into each of the vents of each of the interior walls. A pair of doors provides access to the storage of the undercarriage.

Abstract: An air damper assembly for an air duct having an interior wall and an exterior wall is provided. The air damper assembly includes a damper plate having a periphery and multiple teeth spaced at least partially around and extending from the periphery. The multiple teeth vary in length from a maximum to a minimum over a span of approximately 90 degrees around the periphery. The air damper assembly further includes an axle assembly fixedly coupled to the damper plate and rotatably coupled to the air duct. Rotation of the axle assembly causes the damper plate to rotate within the air duct between a fully open position and a fully closed position to increase or decrease a flow of fluid through the air duct.

Abstract: Materials with etch selectivity with respect to one another and one or more additional etch-stop layers are used in a Josephson junction structure to allow for integration with a Josephson junction with supporting structures such as resistors. Selective etch processes compatible with high volume manufacturing are used to pattern various layers of the Josephson junction structure to provide a Josephson junction, which is electrically coupled to a support structure.

Abstract: Provided are targeted nanoparticles. In certain embodiments, the targeted nanoparticles comprise a nanoparticle and a myeloid cell (MC) targeting moiety stably associated with the outer surface of the nanoparticle. According to some embodiments, the MC targeting moiety is an immunosuppressive myeloid cell (isMC) targeting moiety. In certain embodiments, the targeted nanoparticles further comprise a detectable label (e.g., an in vivo imaging agent), a drug, or both. Also provided are compositions comprising the targeted nanoparticles of the present disclosure. Methods of using the targeted nanoparticles to image MCs (e.g., isMCs) and/or to modulate and/or disrupt MCs (e.g., isMCs) are also provided.

Abstract: An air handling system for a hot air sterilizer apparatus includes a sterilization chamber having an air exhaust portal, an air handling pathway traversing above the sterilization chamber through an upper supply air plenum and traversing below the sterilization chamber through a lower supply air plenum, a circulation fan configured to direct supply air from the air exhaust portal over an upper heating element through the upper supply air plenum and over a lower heating element through the lower supply air plenum, a first temperature sensor in the upper supply air plenum and configured to measure temperature of air downstream from the upper heating element, a second temperature sensor in the lower supply air plenum and configured to measure temperature of air downstream from the lower heating element, and a third temperature sensor at the air exhaust portal and configured to monitor temperature of air exiting the sterilization chamber.

Abstract: An air damper assembly for an air duct having an interior wall and an exterior wall is provided. The air damper assembly includes a damper plate having a periphery and multiple teeth spaced at least partially around and extending from the periphery. The multiple teeth vary in length from a maximum to a minimum over a span of approximately 90 degrees around the periphery. The air damper assembly further includes an axle assembly fixedly coupled to the damper plate and rotatably coupled to the air duct. Rotation of the axle assembly causes the damper plate to rotate within the air duct between a fully open position and a fully closed position to increase or decrease a flow of fluid through the air duct.

Abstract: A method is provided for preventing dark data in a data set. At a time t1, a first version of the data set is received. The first version is analyzed and its parameters are gathered in a first statistical profile. The first statistical profile is stored. At a time t2, a second version of the data set is received. The second version is analyzed and its parameters are gathered in a second statistical profile. The second statistical profile is stored. The first and second statistical profiles are compared and a similarity index is created. If the similarity index exceeds a pre-set threshold, dissimilarity is flagged and a responsive action is taken.

Abstract: A device and system for sterilizing objects, commonly dental, medical, or veterinary instruments, having a double door configuration that can provide entry of contaminated instruments into a sterilizer from a contaminated area and subsequently, post-sterilization, their pass-through directly into a sterile area through an exit door from said sterilizer. More specifically, the invention is a countertop, high velocity, dry heat sterilization device that is readily adaptable for those clinical areas requiring separation of contaminated and sterile areas for the processing of medical, dental, or veterinary instruments. The sterilization device utilizes a dual airflow pathway and a controlled heat delivery system to deliver to the sterilization chamber the supply air having temperature uniformity and air velocity required of the high velocity dry heat sterilization process.

Abstract: A system and method for providing secure cryptoassets in a blockchain platform.