Abstract: Transfusion independence in, and overall survival of, myelofibrosis patients can be improved by selecting a patient specific treatment method. A patient's baseline ferritin level can be used as a biomarker to select a first line treatment. The patient's ferritin levels during treatment can inform decisions about terminating treatment or changing treatments to maintain transfusion dependence and/or convert a patient to transfusion independent from transfusion requiring or transfusion dependent.

Abstract: The invention relates to a splint for an infant. It has a body including an insert of a malleable material, wherein the body has a longitudinal axis, a first arm extending from an edge of the body in a plane substantially perpendicular to the longitudinal axis; and a second arm, spaced apart from the first arm, extending from the edge of the body in a plane substantially perpendicular to the longitudinal axis. The arms wrap around the limb of the infant and provide a surface for using medical tape or the like, thus avoiding the need for the tape to come into contact with the skin of the infant. In addition, the malleable insert allows the splint to be deformed and hold its shape if the splint is to be used on a joint of the limb.

Abstract: A drive assembly for a vehicle is disclosed. The drive assembly comprises a central hub having an axis of rotation; an in-wheel electrical machine comprising a stator and a rotor; and a rim assembly comprising an inward circumferential part and an outward circumferential part, said inward circumferential part and said outward circumferential part being disposed adjacent each other along said axis of rotation, each part comprising a rim section for carrying a respective tyre, wherein the rim assembly is coupled to the hub. The in-wheel electrical machine is arranged outwardly of, and coupled to, the hub. A vehicle comprising the drive assembly is also disclosed.

Abstract: A computer system for dynamically controlling a thermoset printer (100) may comprise one or more processors (210) and one or more computer-readable media having stored thereon executable instructions that when executed by the one or more processors, configure the computer system to perform various acts. The computer system may receive a thermoset printing data packet that comprises an indication of a desired final material property of the target object to be printed. The computer system may also receive an indication of one or more thermoset materials (250a,250b) that are available to the thermoset three-dimensional printer and access a material attribute dataset that describes different material properties. Based upon the material attribute dataset, the computer system may determine a particular mixture configuration for the one or more thermoset materials and generate a command to cause the thermoset three-dimensional printer to implement the particular mixture configuration.

Abstract: A device includes a contact lens, a corneal sensor that includes a circular trace of conduction paths located at or near an outer peripheral edge of the contact lens that surrounds an unobstructed area at a center region of the contact lens, and a connection wire coupled to the corneal sensor and configured to electrically couple to an external data acquisition system. Methods of fabricating the device may include providing a thin device that includes a sensor and a connection wire coupled to the sensor, transferring the sensor to a curvilinear inner surface of a contact lens, feeding the connection wire through the inner surface of the contact lens and out of an outer surface of the contact lens, and performing electrochemical polymerization of a conducting polymer material over the sensor to anchor the sensor to the inner surface of the contact lens.

Abstract: A computer system (110) for controlling a thermoset printer (100) to create desired material attributes comprises one or more processors (210) and one or more computer-readable media (220) having stored thereon executable instructions that when executed by the one or more processors configure the computer system to perform various acts. The computer system may receive an indication of one or more thermoset materials that are to be used by the thermoset printer (100) to print a target object (120). The computer system (110) may also access a material attribute dataset that describes different material properties of the one or more thermoset materials during printing. Based upon the material attribute dataset, the computer system determines a particular extrusion configuration for the one or more thermoset materials and generates a command to cause the thermoset printer to implement the particular extrusion configuration while printing the target object (120).

Abstract: A computer system for dynamically controlling a three-dimensional printer may comprise one or more processors and one or more computer-readable media having stored thereon executable instructions that, when executed by the one or more processors, configure the computer system to perform various acts. The computer system may receive an indication to cause a three-dimensional printer to print a non-planar surface. Additionally, the computer system may calculate multiple different bead sizes for creating the non-planar surface using components of the three-dimensional printer. The computer system may also create a command to generate the multiple different bead sizes at locations within a printing area.

Abstract: The present disclosure relates to methods of treating an inflammatory disease or disorder, the method comprising: administering to a subject in need thereof a therapeutically effective amount of momelotinib (MMB) or a pharmaceutically acceptable salt thereof; and administering to the subject one or more anti-inflammatory agents, and combinations for use in treating an inflammatory disease or disorder.

Abstract: Methods of designing a structure taking into account thermal loads are presented. A method to analyze thermal build-up in a joint is presented. Physical testing between a first material and a second material is performed to determine physical data comprising at least one of stiffness, strain, load, and displacement. The physical data is analyzed. A closed form equation is generated based on the analysis to calculate the thermal build-up in the joint.

Abstract: A veterinary saw assembly having a tool coupler for coupling to an external power tool and a drive coupler for driving a cutting string from the power tool. The cutting string can be an abrasive wire. The power tool can be a drill. The saw assembly can be used for dehorning or foetotomy procedures. Also disclosed are saws that include the saw assembly, cutting strings for use with the saw assembly, methods of stringing the saw assembly with a cutting string, and a kit including the cutting string and instructions for its use.

Abstract: A three-dimensional nanolithography system includes forming a photocurable resin including one or more organic monomers, a photoinitiator, and an inhibitor, defining a lithographical patterning region, directing a light beam toward the lithographical patterning region to initiate polymerization, and controlling an initiator depletion technique to reduce an undesired portion of the polymerization.

Abstract: A central map can be used in a construction environment to help position devices and receive updates from devices to update the central map. Devices in the construction environment, such augmented-reality devices, laser scanners, total stations, satellite navigation receivers, and others can be used to provide “crowd-sourced” data to update the central map as the construction environment changes.

Abstract: Described herein are systems, methods, and non-transitory computer readable media for defining and executing functions for determining a matching entity that is relevant to an entity of interest when, for example, there is a significant number of intermediary links and entities between the matching entity and the entity of interest. A visual depiction of a path traversal from a seed input entity to an output matched entity can be presented to an end user in a manner that allows the end user to ascertain the sequence of intermediary links and entities that connect the matched entity to the seed entity.

Abstract: A breakaway assembly including a first connector and a second connector releasably coupleable to the first connector, wherein the assembly is movable between a first configuration in which the first and second connectors are releasably coupled and together define a fluid path through which fluid is flowable, wherein the fluid path includes an at least partially radially extending portion, and a second configuration in which the first and second connectors are not coupled together. The assembly is configured to move from the first configuration to the second configuration when a predetermined separation force is applied to the assembly. One of the first or second connectors has a shaft which defines or includes at least part of the fluid path therein, and the at least partially radially extending portion includes or is defined by an opening in the shaft.

Abstract: An in-wheel electrical generator for a vehicle is disclosed. The in-wheel generator comprises: a stator configured to be coupled to a non-rotating spindle of a vehicle; and a rotor configured to be indirectly coupled to a rotating hub of a vehicle. The in-wheel electrical generator is configured to be arranged outwardly of the rotating hub. A vehicle comprising such an in-wheel generator is also disclosed, along with an ancillary unit system for a trailer which uses such an in-wheel generator to power the ancillary unit.

Abstract: A provider computing system is configured to receive a request from a computing device of a customer to receive access to one or more disclosure documents associated with a financial account in electronic format, send an electronic consent request to the computing device of the customer to receive the one or more disclosure documents in electronic format, receive a response from the computing device of the customer accepting the electronic consent request, transmit to the computing device of the customer and display on the computing device of the customer the one or more disclosure documents, and create and store an audit trail in a memory location of a customer database associated with a customer account associated with the customer identifier, where the audit trail includes a confirmations that the customer consented to receive the disclosure documents in electronic format and was provided access to the disclosure documents.

Abstract: Methods and systems for imaging a sample using fluorescence microscopy. High resolution lenses can be used for light sheet microscopy by tilting the excitation beam relative to the imaging optical axis. The excitation beam can be tilted using mirrors, instead of lenses, to generate the tilted illumination sheet. In some examples, a light path starts at a top downward-facing cone of light as it emerges from an optic fiber; a first off-axis parabolic mirror collimates in the x-axis, while a second off-axis parabolic mirror collimates in the y-axis, followed by the photomask to create four primary light sheets, which are then focused by a third off-axis parabolic mirror. As the four primary light sheets converge they create an interference pattern at an objective lens.

Abstract: A breakaway assembly including a first connector and a second connector releasably coupleable to the first connector, wherein the assembly is movable between a first configuration in which the first and second connectors are releasably coupled and together define a fluid path through which fluid is flowable, and a second configuration in which the first and second connectors are not coupled together. The assembly is configured to move from the first configuration to the second configuration when a predetermined separation force is applied to the assembly. The assembly includes a closure valve positioned in one of the first or second connectors, wherein the closure valve is configured to be in an open position when the assembly is in the first configuration to allow fluid to flow therethrough, and to move to a closed position when the assembly moves to the second configuration to generally block the flow of fluid therethrough.

Abstract: A computer system for part production using flow infill design receives a computer-aided design file that describes physical dimensions of a target object (120). The computer system identifies a physical boundary portion (300) of the target object within the CAD file. The computer system generates a first tool path to additively manufacture the physical boundary portion (300). Additionally, the computer system sends instructions to a computer system in communication with a dispenser (130) that cause the dispenser to implement the first tool path while dispensing a boundary material. Further, the computer system generates a command to dispense the coreactive infill material (310) within the physical boundary portion.