Patents by Inventor Bryon A. Merrill

Bryon A. Merrill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amide substituted imidazoquinolines
    Patent number: 7393859
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: July 1, 2008
    Assignee: Coley Pharmaceutical Group, Inc.
    Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
  • Intermediates for imidazonaphthyridines
    Publication number: 20080091010
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 17, 2008
    Applicant: Graceway Pharmaceuticals, LLC
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • Intermediates for imidazonaphthyridines
    Patent number: 7335773
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: February 26, 2008
    Assignee: Graceway Pharmaceuticals, LLC
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Thioether substituted imidazoquinolines
    Patent number: 7288550
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: October 30, 2007
    Assignee: 3M Innovative Properties Company
    Inventors: Joseph F. Dellaria, Matthew R. Radmer, Bryon A. Merrill
  • Aryl substituted imidazonaphthyridines
    Publication number: 20070219228
    Abstract: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: September 20, 2007
    Inventors: Shri Niwas, Bryon Merrill, Philip Heppner, Tushar Kshirsagar, Gregory Lundquist, David Amos, Kyle Lindstrom
  • Nitrogen-Containing Heterocyclyl Substituted Imidazoquinolines and Imidazonaphthyridines
    Publication number: 20070213356
    Abstract: Imidazoquinoline and imidazonaphthyridine compounds having a nitrogen-containing heterocyclyl substituent at the 5-, 6-, 7-, or 8-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 15, 2005
    Publication date: September 13, 2007
    Inventors: Bryon Merrill, Chad Haraldson, Tushar Kshirsagar, Shri Niwas
  • Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
    Publication number: 20070208052
    Abstract: Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
    Type: Application
    Filed: June 17, 2005
    Publication date: September 6, 2007
    Inventors: Ryan Prince, Michael Rice, Joshua Wurst, Bryon Merrill, Tushar Kshirsagar, Philip Heppner
  • Alkoxy substituted imidazoquinolines
    Publication number: 20070060754
    Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Application
    Filed: October 1, 2004
    Publication date: March 15, 2007
    Inventors: Kyle Lindstrom, Bryon Merrill, Chad Haraldson, Michael Rice, Tushar Kshirsagar, Philip Heppner, Joshua Wurst, Shri Niwas, Sarah Johannessen
  • Sulfonamido ether substituted imidazoquinolines
    Patent number: 7132429
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: November 7, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: George W. Griesgraber, Bryon A. Merrill, Ralph R. Roberts, Ai-Ping Wei
  • Amido ether substituted imidazoquinolines
    Patent number: 7115622
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: October 3, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, George W. Griesgraber, Philip D. Heppner, Bryon A. Merrill
  • Amide substituted imidazopyridines
    Patent number: 7098221
    Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: August 29, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Philip D. Heppner, Kyle J. Lindstrom, Bryon A. Merrill
  • Aryl substituted Imidazoquinolines
    Patent number: 7091214
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: August 15, 2006
    Assignee: 3M Innovative Properties Co.
    Inventors: David S. Hays, Shri Niwas, Tushar Kshirsagar, Philip D. Heppner, Bryon A. Merrill, Michael E. Danielson, John F. Gerster, Chad A. Haraldson, Maureen A. Kavanagh, Michael J. Rice, Sarah A. Strong, Joshua R. Wurst
  • Urea substituted imidazoquinoline ethers
    Patent number: 7078523
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: July 18, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Stephen L. Crooks, George W. Griesgraber, Philip D. Heppner, Bryon A. Merrill
  • INTERMEDIATES FOR IMIDAZONAPHTHYRIDINES
    Publication number: 20060128674
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
    Type: Application
    Filed: February 13, 2006
    Publication date: June 15, 2006
    Inventors: John Gerster, Kyle Lindstrom, Stephen Crooks, Philip Heppner, Gregory Marszalek, Peter Maye, Bryon Merrill, John Mickelson, Michael Rice
  • ARYL SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20060111387
    Abstract: Aryl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
    Type: Application
    Filed: January 13, 2006
    Publication date: May 25, 2006
    Inventors: David Hays, Tushar Kshirsagar, Philip Heppner, Bryon Merrill, Michael Danielson, John Gerster, Chad Haraldson, Sarah Johannessen, Maureen Kavanagh, Kyle Lindstrom, Michael Rice, David Squire, Sarah Strong, Joshua Wurst
  • Urea substituted imidazoquinoline ethers
    Patent number: 7049439
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: May 23, 2006
    Assignee: 3M Innovative Properties Co.
    Inventors: Stephen L. Crooks, George W. Griesgraber, Philip D. Heppner, Bryon A. Merrill
  • METHOD OF USING SULFONAMIDE SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20060106052
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Application
    Filed: January 25, 2006
    Publication date: May 18, 2006
    Inventors: Stephen Crooks, Bryon Merrill
  • Imidazonaphthyridines
    Patent number: 7038051
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: May 2, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Sulfonamide substituted imidazoquinolines
    Patent number: 7030131
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: April 18, 2006
    Inventors: Stephen L. Crooks, Bryon A. Merrill
  • Aryl ether substituted imidazoquinolines
    Patent number: 6989389
    Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and aryl or alkenyl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: January 24, 2006
    Assignee: 3M Innovative Properties Co.
    Inventors: Philip D. Heppner, Leslie J. Charles, Joseph F. Dellaria, Bryon A. Merrill, John W. Mickelson