Abstract: The present invention relates to an inhaler with a novel mouthpiece having a microbiological protective function. The inhalers are used for administration of a pharmaceutical substance, substance formulation or substance mixture.

Abstract: The present invention relates to medicament blisters for powder inhalers. The blisters according to the invention contain an inhalable powder comprising a medicament. The blisters are characterised by a reduced permeability for water vapour, which is achieved by decreasing the height of the sealing lacquer layer.

Abstract: A process for the production of a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and also a container produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process is to form a pressure equalisation opening in the outer container of the container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.

Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: The invention relates to a blister for charging an inhaler with a pharmaceutical preparation, characterised in that the blister is at least partially manufactured from a dehydrating plastics material. The invention also relates to blisters according to the invention which are filled with a pharmaceutical preparation.

Abstract: The present invention relates to a method for reliably and rapidly checking the leaktightness of sealed containers or their leakage rate by the action of a gas thereon. The method according to the invention is particularly suitable for checking the leaktightness of blisters for pharmaceutical formulations of active substance.

Abstract: A process for the production of a container (1) comprising an outer container (2), an inner bag (3) disposed therein and a pressure equalisation opening (10) disposed in the outer container (2), and also a container (1) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam (5) being formed. The process is to form a pressure equalisation opening (10) in the outer container (2) of the container (1) without endangering the integrity of the container (1), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam (5) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40° C. to 70° C.

Abstract: The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water vapor and organic molecules.

Abstract: The invention relates to a novel capsule for receiving an active substance to be administered by inhalation, which is preferably intended for use in a powder inhaler operating on the Bernoulli principle.

Abstract: The present invention relates to a method for reliably and rapidly checking the leaktightness of sealed containers or their leakage rate by the action of a gas thereon. The method according to the invention is particularly suitable for checking the leaktightness of blisters for pharmaceutical formulations of active substance.

Abstract: For the extrusion of extruded profiles with a color pattern or their coating with such a color pattern, a plasticized material of at least two-colors is used, which is separated into at least two partial flows. These partial flows are combined before they exit the extruding head (1), whereby the partial flows are largely maintained. These partial flows can in turn be separated into further partial flows. The extruding head (1) is equipped with a distribution plate (4) in which distribution channels (8a, b) as well as a ring channel (11) are formed as grooves, with the ring channel connected to an the exit channel (38) through a ring slot (19, 20). The plasticized material entering through the ring slot (19, 20) into the exit channel (38) coats the pre-manufactured extruded profile (39) inserted through the guidance part (13) and the die arbor (24).

Abstract: In the course of the process of manufacturing pencils the polymer binding material is at first melted in a lead extruder (19) in order to manufacture the lead. To the melted polymer material is then added via a loading extruder (2) a mixture of additives in powder form such as colors, gliding and adhesive substances. After intensive mixing of the components in the lead extruder (1) a lead profile (13) is extruded which is cooled in a first cooling range (3) to the point where, upon entering the coating nozzle (6), it is not fully plastic anymore but also not completely cold. Through the coating extruder (4) and (5) the appropriate materials are introduced for the formation of the pencil coating. In the course of the subsequent second cooling range (8) the pencil profile is cooled down completely and after passing the withdrawal station (11) it is cut in a sawing station (12).