Abstract: Disclosed embodiments provide a computer-implemented technique for creating a log chain from multiple software component logs. The log chain can include log information from multiple software components that interact with each other. In embodiments, a locality-sensitive hashing technique is used to create a signature of a log chain. Machine-learning systems are trained with log chains generated from test execution, and/or log chains from incidents with deployed software. In embodiments, logs are pre-processed by tokenizing and trimming. Logs from various components that interact with each other may be combined into a temporally sequential log chain. The signature of the log chain may be used to identify additional information about the error from a machine-learning process that was trained on previously generated log chains. In this way, the time required to identify a problem can be significantly reduced, resulting in increased reliability and availability of complex computer systems.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

Abstract: Methods and corresponding catalysts are provided for transalkylation of 1-ring (C9+) aromatic compounds, such as transalkylation to form para-xylene and/or other xylenes. Suitable catalysts include molecular sieves having a 3-D 12-member ring framework structure, molecular sieves having a 1-D 12-member ring framework structure, acidic microporous materials with a pore channel size of at least 6.0 Angstroms, and/or molecular sieves having a MWW framework structure. The methods include performing transalkylation where at least a portion of the feed to the transalkylation process is in the liquid phase. Optionally, the transalkylation conditions can correspond to conditions where a continuous liquid phase is present within the reaction environment. Some embodiments include liquid phase transalkylation processes for naphthalene-containing feedstock streams.

Abstract: Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.

Abstract: Technical solutions are described for securing data by a communication apparatus. An example computer-implemented method includes receiving, by an encryption engine, a request to apply cryptography to input data. The computer-implemented method also includes generating metadata for the input data, where the metadata identifies characteristics of content included in the input data. The method further includes applying a cryptographic technique to the input data to generate output data, and outputting the output data and metadata in response to the request.

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

Abstract: Technical solutions are described for preventing unauthorized transmission of data by a communication apparatus. An example computer-implemented method includes monitoring a data transmission request from an application being executed by the communication apparatus. The data transmission request is associated with transmission data. The method further includes securing the transmission data, where the securing includes identifying a content of a predetermined type in the transmission data, and generating secured transmission data. The secured transmission data includes a corresponding modified version of the content of the predetermined type. The computer-implemented method also includes transmitting the secured transmission data in response to the data transmission request.

Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.

Abstract: Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.

Abstract: Apparatus and methods for therapy delivery are disclosed. In one embodiment, a therapy delivery system includes a plurality of movable components including a radiation therapy nozzle and a patient pod for holding a patient, a patient registration module for determining a desired position of at least one of the plurality of movable components, and a motion control module for coordinating the movement of the least one of the plurality of movable components from a current position to the desired position. The motion control module includes a path planning module for simulating at least one projected trajectory of movement of the least one of the plurality of moveable components from the current position to the desired position.

Abstract: Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.

Abstract: Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.

Abstract: Peptide compositions having bacteriocidal peptides are described. Also described is a method of bacterial infections using compositions comprising bacteriocidal peptides or modified peptides with structural relationships to cathelicidins.

Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, I or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.

Abstract: Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

Abstract: Technical solutions are described for preventing unauthorized transmission of data by a communication apparatus. An example computer-implemented method includes monitoring a data transmission request from an application being executed by the communication apparatus. The data transmission request is associated with transmission data. The method further includes securing the transmission data, where the securing includes identifying a content of a predetermined type in the transmission data, and generating secured transmission data. The secured transmission data includes a corresponding modified version of the content of the predetermined type. The computer-implemented method also includes transmitting the secured transmission data in response to the data transmission request.