Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: In one embodiment, a remote controller for a vehicle includes at least one control element for controlling operation of at least one aspect of the vehicle when the vehicle is in a remote-control mode; an actuator connected the at least one control element for controlling a position of the at least one control element when the vehicle is in an autonomous operations mode; and a processing system for receiving a first control signal from the vehicle indicative of a state of operation of the vehicle. In operation, the processing system generates a second control signal to the actuator to cause the actuator to control a position of the control element such that it corresponds to and indicates the state of operation of the vehicle.

Abstract: While a qubit control system (e.g., a laser system) is in a first configuration, it causes a qubit state (as represented as a point on the surface of a Bloch sphere) of a quantum state carrier (QSC), e.g., an atom, to rotate in a first direction from an initial qubit state to a first configuration qubit state. While the qubit control system is in a second configuration, it causes the QSC state to rotate in a second direction opposite the first direction from the first configuration qubit state to a second configuration qubit state. The second configuration qubit state is read out as a |0 or |1. Repeating these actions results in a distribution of |0s and |1s that can be used to determine which of the two configurations results in higher Rabi frequencies. Iterating the above for other pairs of configurations can identify a configuration that delivers the most power to the QSC and thus yields the highest Rabi frequency.

Abstract: A chomping bubble producing toy including a shaft secured between a bubble solution reservoir and a housing. The housing is the shape of a character and includes an upper and moveable lower jaw piece. A lever is secured to a connection rod within the housing, which connection rod is secured to the lower jaw about a rotational axle. When the lever is pulled, the connection rod moves upward, which pushes the lower jaw down about the fixed rotational axle. A compression spring is secured to the connection rod, which spring keeps the jaw closed when the lever is at rest. Secured within the housing adjacent to the connection rod is a lever switch. When the lever is pulled, the connection rod moves and contacts the lever switch, thereby triggering it, which automatically plays sound from a speaker within the device and/or transmits a wireless signal.

Abstract: Bands for wearable devices include multiple band retainers used to maintain engagement between an assembly (e.g., a pair) of bands. Some band retainers may be permanently affixed with the band at a certain location of the band, while other band retainers can be removable. The removable band retainers can be moved to different locations of the band, thus allowing the band retainer to retain another band at different locations. As a result, the assembly of bands can be used with different users, and in particular, users with different wrist sizes. Moreover, using multiple band retainers can provide an engagement force between the bands to withstand higher-impact events, such as swimming and diving. Additionally, bands and band retainers may include one or more liquid-resistant and corrosion-resistant materials.

Abstract: A method includes a step of obtaining plural pieces of training data each of which includes a different radiographic image of a bone and each of which has a label indicating one of an overt fracture, an occult fracture and no fracture, a step of using the plural pieces of training data to pre-train a deep convolutional network (DCN) model to obtain a preliminary DCN model, a step of determining a subset of the plural pieces of training data by at least excluding any piece of training data that has a label indicating occult fracture, and a step of using the subset to train the preliminary DCN model to obtain a first DCN model.

Abstract: A policy-controlled authorization system including a local application on a client device, a policy component including a plurality of policies, and a mid-link server, coupled to the client device is provided. A request for access to a service using a token is provided by the local application. A correlator correlates the token with the plurality of tokens for identifying a policy from the plurality of policies associated with the token. A token inspector authorizes the token for accessing the service based on the correlation. Based on the authorization, either the token is authorized for access to the service via the remote application, or the token is blocked when unauthorized to prevent access to the service. Confidence scores are assigned to each token based on their categories, compliance with the policies, and a threat level. The confidence scores indicate need to re-authorize the tokens and/or disable them temporarily.

Abstract: A policy-controlled access security system for managing access security to electronic agents in cloud based multi-tenant systems includes a client device, a mid-link server, and a web server. A local application running on the client device requests access to an electronic agent of a remote application of the web server. Policies are determined for controlled access to the electronic agent. A token for the electronic agent is correlated with a plurality of tokens for identifying a user application associated with the token. The remote application is compared with the user application. A non-compliance of the set of policies is identified by determining enabling of one or more AI devices by the plurality of end users. The set of policies are modified based on the non-compliance and the functionality associated with the electronic agent and the plurality of privileges are updated for the end user based on the modified policies.

Abstract: A policy-controlled authorization system including a local application on a client device, a policy component including a plurality of policies, and a mid-link server, coupled to the client device is provided. A request for access to a service using a token is provided by the local application. A correlator correlates the token with the plurality of tokens for identifying a policy from the plurality of policies associated with the token. A token inspector authorizes the token for accessing the service based on the correlation. Based on the authorization, either the token is authorized for access to the service via the remote application, or the token is blocked when unauthorized to prevent access to the service. Confidence scores are assigned to each token based on their categories, compliance with the policies, and a threat level. The confidence scores indicate need to re-authorize the tokens and/or disable them temporarily.

Abstract: An OTP with ultra-low power read can be programmed with a minimum and a maximum program voltage. When programming within the range, the post-program OTP to pre-program resistance ratio can be larger than N, where N>50, so that more sensing techniques, such as single-end sensing, can be used to reduce read current. At least one of the OTP cells can be coupled to a common bitline, which can be further coupled to a first supply voltage lines via a plurality of datalines. The resistance in the at least one OTP cell can be evaluated by strobing at least one comparator output of the discharging bitline/dataline.

Abstract: A policy-controlled access security system for managing access security to electronic agents in cloud based multi-tenant systems includes a client device, a mid-link server, and a web server. A local application running on the client device requests for access to an electronic agent of a remote application of the web server. Policies are determined corresponding to the electronic agent for controlled access to the electronic agent. A token for the electronic agent is correlated with a plurality of tokens for identifying a user application associated with the token. The remote application corresponding to the token from the request is compared with the user application. Based on the comparison an authorization is determined by the mid-link server corresponding to the token for accessing the electronic agent. The policies are enforced on the client device and the access to the electronic agent is provided based on the policies via the web server.

Abstract: A policy-controlled authorization system for managing tokens used to access services in a cloud based multi-tenant system. The policy-controlled authorization system includes a local application that executes on a client device, a policy component including a plurality of policies, and a mid-link server, coupled to the client device. A request for access to a service on a remote application running on a remote instance of a web server is provided by the local application. A token is required to access the service. A correlator correlates the token with the plurality of tokens for identifying a policy from the plurality of policies associated with the token. A token inspector authorizes the token for accessing the service based on the correlation. Based on the authorization, either the token is authorized for access to the service via the remote application, or the token is blocked when unauthorized to prevent access to the service.

Abstract: An electronic device and method of generating a Physically Unclonable Function (“PUF”) value is disclosed. An OTP memory with a plurality of OTP cells that can be reliably and deterministically programmed with a minimum and a maximum program voltage being selected for pre-conditioning. All OTP cells can be programmed at least once around the minimum program voltage to hide the program status. Data to be programmed into the OTP can be a fixed, time-varying voltage or data from an entropy source. The programmed OTP data can be masked for weak bits and further randomized to generate PUF output by compressing a bit stream into a single bit, e.g., single parity bit. The PUF output can be through a hash function and/or to generate keys.

Abstract: Programmable resistive memory can be integrated with wide-bandgap semiconductor devices on a wide-bandgap semiconductor, silicon, or insulator substrate. The wide-bandgap semiconductor can be group IV-IV, III-V, or II-VI crystal or compound semiconductor, such as silicon carbide or gallium nitride. The programmable resistive memory can be PCRAM, RRAM, MRAM, or OTP. The OTP element can be a metal, silicon, polysilicon, silicided polysilicon, or thermally insulated wide-bandgap semiconductor. The selector in a programmable resistive memory can be a MOS or diode fabricated by wide-bandgap semiconductor.

Abstract: An OTP with ultra-low power read can be programmed with a minimum and a maximum program voltage. When programming within the range, the post-program OTP to pre-program resistance ratio can be larger than N, where N>50, so that more sensing techniques, such as single-end sensing, can be used to reduce read current. At least one of the OTP cells can be coupled to a common bitline, which can be further coupled to a first supply voltage lines via a plurality of datalines. The resistance in the at least one OTP cell can be evaluated by strobing at least one comparator output of the discharging bitline/dataline.

Abstract: A method includes a step of obtaining plural pieces of training data each of which includes a different radiographic image of a bone and each of which has a label indicating one of an overt fracture, an occult fracture and no fracture, a step of using the plural pieces of training data to pre-train a deep convolutional network (DCN) model to obtain a preliminary DCN model, a step of determining a subset of the plural pieces of training data by at least excluding any piece of training data that has a label indicating occult fracture, and a step of using the subset to train the preliminary DCN model to obtain a first DCN model.

Abstract: A time-based sensing circuit to convert resistance of a one-time programmable (OTP) element into logic states is disclosed. A one-time programmable (OTP) memory has a plurality of OTP devices. At least one of the OTP devices can have at least one OTP element that is selectively accessible via a wordline and a bitline. The bitline can be coupled a capacitor and the capacitor can be precharged and discharged. By comparing the discharge rate of the capacitor to discharge rate of a reference capacitor in a reference unit (e.g., reference cell, reference resistance, reference selector, etc.), the PRE resistance can be determined larger or smaller than a reference resistance and then converting the OTP element resistance into a logic state.

Abstract: An application may be integrated into an operating system component of a mobile computing platform. The application communicates registration information to an extension mechanism within the mobile computing platform. The extension mechanism registers the application and modifies the operating system component to provide interoperability with the application based on the registration information. The extension mechanism couples the operating system component with content from a counterpart application to the application, which corresponds to information presented on the operating system component.