Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematological, among others.

Abstract: A method for maintaining a consistent blockchain ledger for storing commitments across multiple separate blockchains includes: storing a blockchain comprised of a plurality of blocks, each block including at least a block header and one or more blockchain data values; receiving a base commitment from a first node, where the first node is included in a first blockchain network; generating a first new block including at least a first block header and the received base commitment; storing the first new block in the blockchain; receiving a state commitment from an additional node included in each of at least two additional blockchain networks; generating an additional new block including at least an additional block header and each received state commitment; and storing the additional new block in the blockchain.

Abstract: A method for verification of a data value via a Merkle root includes: storing, in a memory of a processing server, a Merkle root; receiving at least a data value, a nonce, and a plurality of hash path values; generating a combined value by combining the data value and the nonce; generating a first hash value via application of a hashing algorithm to the combined value; generating a subsequent hash value via application of the hashing algorithm to a combination of the first hash value and a first of the plurality of hash path values; repeating generation of the subsequent hash value using a combination of the next hash path value of the plurality of hash path values and the most recent subsequent hash value; and verifying the data value based on a comparison of the Merkle root and the last generated subsequent hash value.

Abstract: A process for preparing a rubber vulcanizate, the process comprising (i) providing a vulcanizable composition of matter including a sulfur-based curative, zinc oxide, and a eutectic solvent; and (ii) heating the vulcanizable composition to thereby effect vulcanization.

Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tis -sue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.

Abstract: A system for enabling communication between blockchains on heterogeneous blockchain networks. The system can include a sending blockchain network comprised of a sending blockchain that includes a plurality of blocks, each block including a block header and one or more transaction values associated with an identification request transmitted by the sending blockchain. The system can include a directory service node configured to receive the identification request from the sending blockchain, and identify a receiving blockchain, which forms part of a receiving blockchain network. The system can include an identity service node configured to receive a trust request from the directory service node to determine whether a valid trust certificate is available for the receiving blockchain and enable communication between the sending blockchain and the receiving blockchain, when the valid trust certificate is determined to be available.

Abstract: An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.

Abstract: A method for generation of blocks for a partitioned blockchain includes: storing blocks comprising a partitioned blockchain, wherein each block includes a header and transaction entries; receiving transaction data entries for each of a plurality of subnets; generating a hash value of the header included in the most recently added block; generating a new block header, the new block header including the generated hash value, a timestamp, and a sequence of pairs including a pair for each of the plurality of subnets, each pair including a subnet identifier associated with the respective subnet and a merkle root of each of the transaction data entries received for the respective subnet; generating a new block, the new block including the generated new block header and the transaction data entries for each of the plurality of subnets; and transmitting the new block to a plurality of nodes associated with the partitioned blockchain.

Abstract: Embodiments of a microelectronic assembly comprise a first integrated circuit (IC) die including a plurality of first circuits separated by scribe regions, and a plurality of second IC dies coupled to the first IC die, each one of the second IC dies being coupled proximate and adjacent to a corresponding one of the first circuits and conductively coupled to the corresponding one of the first circuits. One or more of the second IC dies comprises a second circuit different from the first circuit, adjacent ones of the first circuits are coupled by a conductive pathway through the corresponding scribe regions, and the first IC die and the second IC die are coupled by interconnects having a pitch not more than 10 micrometers between adjacent interconnects.

Abstract: A head unit device for controlling motion of an object includes shear thickening fluid (STF), an alternative STF (ASTF), and a chamber configured to contain a portion of the STF and the ASTF. The chamber further includes a piston compartment and an alternative reservoir. The head unit device further includes an evacuator and a reservoir injector configured within the chamber, and a piston housed at least partially radially within the piston compartment. The evacuator and the reservoir injector function to adjust flow of the ASTF from the alternative reservoir to the piston compartment to cause selection of one of a variety of shear rates for a mixture of the STF and the a STF within the piston compartment.

Abstract: A method for minimizing aircraft collisions, includes detecting a flight of an unmanned aerial system (UAS) in a restricted area and determining a location of a radio frequency (RF) emitter in communication with the UAS. The method includes, at each of a plurality of RF sensors of a network of wireless RF sensors, receiving RF emissions within an RF band pertaining to UAS control, processing the received RF emissions, and transmitting data derived from the processed RF emissions. The method further includes at a designated one of the plurality of RF sensors, receiving the transmitted data from the RF sensors, a processor computing, using the transmitted data received from the RF sensors, a location estimate for the RF emitter and to predict the UAS is flying, and based on the prediction, the processor generating an alert.

Abstract: A medium-voltage switchgear system includes a three-phase circuit breaker having first, second and third single-phase vacuum interrupters connected between respective first, second and third single-phase inputs and first, second and third single-phase outputs. Magnetic actuators are connected to first, second and third single-phase vacuum interrupters, which are configured to receive an interrupt signal and in response, actuate the respective vacuum interrupter connected thereto into an open circuit condition. A controller circuit is connected to each of the first, second and third magnetic actuators and generates an interrupt signal in response to a detected single-phase overcurrent or fault on a single-phase circuit and interrupt that single-phase circuit on which the single-phase overcurrent or fault occurred and maintain power on the remaining two single-phase circuits over which a single-phase overcurrent or fault was not detected.

Abstract: A switchgear system may include a switchgear frame, a truck and circuit breaker mounted thereon. A drive mechanism is mounted on the switchgear frame and configured to rack the circuit breaker into a) a first connected position where the primary and secondary circuits are electrically connected, b) a second test position where the primary circuit is electrically disconnected and secondary circuit connected, and c) a third disconnected position where the primary and secondary circuits are electrically disconnected, wherein said drive mechanism comprises a drive chain and shuttle configured to engage the truck and rack and fix the circuit breaker into the first connected position.

Abstract: A switchgear system includes a switchgear frame having an interior compartment and front opening and containing therein at least one electrical switchgear component. A truck carries an electrical component and is supported for movement on the switchgear frame. A drive mechanism connects the truck and is configured to rack in the truck into an electrically connected position with the at least one electrical switchgear component, rack out the truck from the electrically connected position into an electrically disconnected position, and rotate the truck upward from its disconnected position into a rotated position to allow operator access through the front opening to the at least one electrical component.

Abstract: Described herein is a modular parallel processor comprising an active base die including hardware logic, interconnect logic, and a plurality of chiplet slots and a plurality of chiplets vertically stacked on the active base die and coupled with the plurality of chiplet slots of the active base die. The plurality of chiplets is interchangeable during assembly of the modular parallel processor and include a group of hardware logic chiplets having a plurality of different functional units and a group of memory chiplets having a plurality of different memory devices. The hardware logic chiplets and the memory chiplets interconnect via the interconnect logic within the active base die.

Abstract: Described herein is a modular parallel processor and associated manufacturing method in which the parallel processor is assembled from multiple chiplets that populate multiple chiplet slots of an active base chiplet die. The multiple chiplets are tested to determine characteristics of the chiplet, such as a number of functional units or a power consumption metric for the chiplet. The multiple chiplet slots can be configured to be populated by one or more chunks of multiple chiplets, where each chunk has a pre-determined collective value. The pre-determined collective value can be a total number of functional execution cores within a chunk or a collective power metric for the chunk.

Abstract: Devices, systems, and methods for eliminating noise in non-invasive biological interrogation techniques may be described herein. A method may include taking a first set of measurements over a time period. The first set of measurements may be indicated by an electronic signal. The first set of measurements may correspond to a physiological characteristic of a subject. A change in the physiological characteristic of the subject may correspond to a change in a blood constituent of the subject. The method may include: taking a second set of measurements over the time period; correlating the first and second sets of measurements, wherein the correlating removes noise from the electronic signal; sectioning out the electronic signal; calculating an amplitude difference between two or more sections of the electronic signal; and determining a change in the amount of the blood constituent based on the difference.

Abstract: A switchgear system includes a switchgear frame having an interior compartment and front opening and containing therein at least one electrical switchgear component. A truck carries an electrical component and is supported for movement on the switchgear frame. A drive mechanism connects the truck and is configured to rack in the truck into an electrically connected position with the at least one electrical switchgear component, rack out the truck from the electrically connected position into an electrically disconnected position, and rotate the truck upward from its disconnected position into a rotated position to allow operator access through the front opening to the at least one electrical component.

Abstract: A method for atomic exchange of assets on multiple blockchains using transient key pairs includes: generating, by a first computing device, a proposal message, the proposal message including at least a first transaction value, a first network identifier corresponding to a first blockchain, a second transaction value, a second network identifier corresponding to a second blockchain, and a swap public key of a swap cryptographic key pair; generating, by the first computing device, a first digital signature for the proposal message; encrypting, by the first computing device, the first digital signature using the swap public key and a first private key of a first cryptographic key pair; appending, by the first computing device, the encrypted first digital signature to the generated proposal message; and transmitting, by the first computing device, the generated proposal message with appended encrypted first digital signature to a second computing device.

Abstract: A method for moderation in a permissioned blockchain using a hash-oriented scheme includes: storing a blockchain including a most recent block; receiving transaction data values; receiving a first reference value and a second reference value; generating a first hash value by hashing the first reference value; generating a block proof including the first hash value, a second hash value, a third reference value, and a block value; verifying a block header of the most recent block using the block proof; receiving a new block value; generating a new block header including the first reference value, the second reference value, a fourth reference value, and the new block value; generating a new block for the blockchain including the new block header and the transaction data values; and transmitting the new block to one or more additional nodes associated with the blockchain.