Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

Abstract: A system includes an imaging system and a tracking system. The system generates a navigation space based on one or more tracking signals emitted by a transmission device. The system generates a virtual space including at least a portion of a calibration phantom based on one or more images generated by the imaging system. The system identifies a set of coordinates in the virtual space in response to an event in which at least a portion of the tracked device is detected in the one or more images. The system calibrates a first coordinate system associated with the virtual space with respect to a second coordinate system associated with the navigation space in response to the event. Calibrating the first coordinate system with respect to the second coordinate system is based on the set of coordinates and temporal information associated with the event.

Abstract: Systems and methods for determining one or more phases of anatomical movement are provided. A catheter positioned in an anatomical element may be tracked using a tracker configured to track a pose of the catheter. Sensor data corresponding to a plurality of pose information of the catheter may be received from the tracker. One or more phases of motion of the anatomical element may be determined based on the plurality of pose information. An image may be received at a target phase of the one or more phases.

Abstract: An example of subject may deliver a therapy by delivering energy to tissue. The system may comprise a magnetic field system and an electric field system. The magnetic field system may be configured to provide a magnetic field in a first direction to the tissue. The magnetic field system may include at least one magnetic field source to produce the magnetic field. The magnetic field produced by the at least one magnetic field source may include a magnetic field produced by at least one of a permanent magnet, a temporary magnet or electric current flow through a conductor. The electric field system may be configured to provide an electric field in a second direction to the tissue. The electric field system may include at least one electric field source to provide the electric field and the second direction is non-parallel to the first direction.

Abstract: This disclosure details a coolant distribution module as used in a thermal management systems for thermally managing electrified vehicle components. An exemplary coolant distribution module includes a module body including a plurality of inlet ports and a plurality of outlet ports, a first manifold valve encompassed within the module body, and a second manifold valve encompassed within the module body. The first manifold valve includes a plurality of first valve inputs wherein each first valve input is in communication with at least one inlet port of the plurality of inlet ports, and a plurality of first valve outputs wherein each first valve output is in communication with at least one outlet port of the plurality of outlet ports.

Abstract: Strategies for an objective associated with an offering set are obtained. A strategy assigns respective selection probabilities of receiving content associated with the offering set to users of a user population. Strategy optimization iterations are performed with respect to a sub-sample of the population and a subset of the strategies. In a given iteration, weights assigned to the strategies are used to determine aggregated selection probabilities for users, content pertaining to the offering set is presented to users selected based on the aggregated probabilities, and the weights are adjusted based on feedback metrics and an exploration-exploitation tradeoff parameter. Based on weights updated in the iterations, content associated with the offering set is presented to users which were not in the sub-sample.

Abstract: A vector and methods of using the vector for, for example, to prevent, inhibit or treat glaucoma, decrease intraocular pressure or to reduce MYOC expression in a mammal, are provided.

Abstract: A system may include one, two or more magnetic field systems. The magnetic field system may be configured to provide a magnetic field in a first direction to the tissue. The magnetic field system may include at least one magnetic field source to produce the magnetic field. The magnetic field produced by the at least one magnetic field source may include a magnetic field produced by at least one of a permanent magnet, a temporary magnet or electric current flow through a conductor. The same or a second magnetic field system may be configured to provide a second magnetic field in a second direction to the tissue. The magnetic field system may include two or more sources to provide the magnetic field in a second, third or fourth direction that is non-parallel to the first direction.

Abstract: This disclosure details a coolant distribution module as used in a thermal management systems for thermally managing electrified vehicle components. An exemplary coolant distribution module includes a module body including a plurality of inlet ports and a plurality of outlet ports, a first manifold valve encompassed within the module body, and a second manifold valve encompassed within the module body. The first manifold valve includes a plurality of first valve inputs wherein each first valve input is in communication with at least one inlet port of the plurality of inlet ports, and a plurality of first valve outputs wherein each first valve output is in communication with at least one outlet port of the plurality of outlet ports.

Abstract: A thermal compensator, for use in connection with arrayed waveguide grating (AWG) modules which are, in turn, utilized in conjunction with wavelength multiplexing and de-multiplexing within optical networks, is disclosed. The thermal compensator comprises a bow-shaped frame member and a central bar member. The bow-shaped frame member is characterized by a higher coefficient of thermal expansion than that of the central bar member such that the bow-shaped frame member can expand and contract at variable rates compared to that of the central bar member under certain temperature conditions. The bow-shaped frame member is adapted to be attached to a movable section of an athermal arrayed waveguide grating (AAWG) module such that the expansion and contraction movements of the bow-shaped member influence the movement of a movable section of the AAWG module in order to maintain the proper focus of the AAWG module across disparate temperature conditions.

Abstract: This disclosure details integrated thermal management systems for thermally managing electrified vehicle components. Exemplary integrated thermal management systems may include a thermal module assembly that may be integrated into a front end structure of a flexible modular platform of the electrified vehicle. The integrated thermal management systems may be controlled in a plurality of distinct thermal control modes for thermal managing various subcomponents and for addressing various vehicle auxiliary loads (e.g., passenger cabin heating loads, passenger cabin cooling loads, etc.).

Abstract: The present invention provides high-complexity defined gut microbial communities capable of achieving substantial engraftment and having stability following human fecal community microbial challenge and methods of producing the same. Also provided are methods of using high-complexity defined gut microbial communities for the treatment of dysbiosis or a pathological condition in an animal.

Abstract: This disclosure details a coolant distribution module as used in a thermal management systems for thermally managing electrified vehicle components. An exemplary coolant distribution module includes a module body including a plurality of inlet ports and a plurality of outlet ports, a first manifold valve encompassed within the module body, and a second manifold valve encompassed within the module body. The first manifold valve includes a plurality of first valve inputs wherein each first valve input is in communication with at least one inlet port of the plurality of inlet ports, and a plurality of first valve outputs wherein each first valve output is in communication with at least one outlet port of the plurality of outlet ports.

Abstract: Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

Abstract: This disclosure details a coolant distribution module as used in a thermal management systems for thermally managing electrified vehicle components. An exemplary coolant distribution module includes a module body including a plurality of inlet ports and a plurality of outlet ports, a first manifold valve encompassed within the module body, and a second manifold valve encompassed within the module body. The first manifold valve includes a plurality of first valve inputs wherein each first valve input is in communication with at least one inlet port of the plurality of inlet ports, and a plurality of first valve outputs wherein each first valve output is in communication with at least one outlet port of the plurality of outlet ports.

Abstract: This disclosure details integrated thermal management systems for thermally managing electrified vehicle components. Exemplary integrated thermal management systems may include a thermal module assembly that may be integrated into a front end structure of a flexible modular platform of the electrified vehicle. The integrated thermal management systems may be controlled in a plurality of distinct thermal control modes for thermal managing various subcomponents and for addressing various vehicle auxiliary loads (e.g., passenger cabin heating loads, passenger cabin cooling loads, etc.).

Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

Abstract: An apparatus and method are provided for purifying air for breathing. The apparatus includes an armrest having a receiver and an air purification module releasably received in the receiver. The air purification module is portable and displaceable between a first operating position held in the receiver and a second operating position remote from the armrest and the vehicle.

Abstract: An agility trainer apparatus that provides a robotic system that applies forces laterally to a harness worn by a person during walking so as to provide highly controllable interventions targeting locomotor stability.

Abstract: An example may deliver a therapy by delivering energy to tissue. A method may include delivering energy to the tissue by providing a magnetic field in a first direction to the tissue using a magnetic field system including a magnetic field source to produce the magnetic field, wherein the magnetic field produced by the magnetic field source includes a magnetic field produced by at least one of a permanent magnet, a temporary magnet or electric current flow through a conductor, and providing an electric field in a second direction to the tissue using an electric field system including an electric field source to produce the electric field, wherein the second direction is non-parallel to the first direction. The method may further include detecting biomarker(s) within at least one of a redox system and a metabolic system to monitor efficacy of the therapy and/or calibrate or adjust the therapy.