Patents by Inventor C. Jensen

C. Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170152480
    Abstract: A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 1, 2017
    Inventor: Michael C. Jensen
  • Publication number: 20170152297
    Abstract: The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor under the control of an inducible promoter. In some alternatives the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a chimeric antigen receptor comprising a ligand binding domain, a polynucleotide comprising a spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain under the control of a drug inducible promoter. Controlling the expression of the chimeric receptor provides for the ability to turn expression on and off depending on the status of the patient.
    Type: Application
    Filed: April 8, 2015
    Publication date: June 1, 2017
    Inventor: Michael C. Jensen
  • Publication number: 20170102404
    Abstract: Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The fluidics devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized.
    Type: Application
    Filed: November 26, 2016
    Publication date: April 13, 2017
    Inventors: Randall Edwin McClelland, David J. Sloan, Timothy C. Jensen, Maureen Kay Bunger
  • Publication number: 20170029774
    Abstract: Aspects of the invention described herein include methods of treating, inhibiting, ameliorating and/or eliminating a virus or cancer cells in a subject utilizing genetically engineered human T-cells having receptors for a molecule presented by the virus or the cancer cells, wherein the genetically engineered T cells are isolated utilizing a two-stage MTX selection that employs increasing concentrations of MTX.
    Type: Application
    Filed: April 8, 2015
    Publication date: February 2, 2017
    Inventors: Michael C. Jensen, Suzie Pun, Nataly Kacherovsky
  • Publication number: 20170022492
    Abstract: Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains formaldehyde. The technique relies on the use of 2-imidazolidone and a protease enzyme, such as proteinase K, at elevated temperatures. Advantageously, RNA can be isolated and used as a template in nucleic acid amplification reactions.
    Type: Application
    Filed: March 21, 2014
    Publication date: January 26, 2017
    Inventors: Deborah C. JENSEN, Brett W. KIRKCONNELL, Timothy J. WILSON
  • Publication number: 20170024789
    Abstract: One variation of a method for fulfilling custom food orders includes: in response to request for a custom food order from a patron through an ordering portal executing on a computing device, retrieving a location of the computing device; identifying a set of food assembly apparatuses within a threshold distance of the location of the computing device; aggregating a list of ingredients currently loaded into the set of food assembly apparatuses; in response to selection of a particular ingredient in the list of ingredients for the custom food order, removing ingredients, from the list of ingredients, unique to a food assembly apparatus not currently loaded with the particular ingredient; selecting a particular food assembly apparatus, from the set, currently loaded with a set of ingredients specified in the custom food order; and inserting the custom food order into a food order queue assigned to the particular food assembly apparatus.
    Type: Application
    Filed: March 28, 2016
    Publication date: January 26, 2017
    Inventors: Steven Frehn, Alexandros Vardakostas, Jeffrey C. Jensen
  • Publication number: 20170021353
    Abstract: Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Systems may be configured with multiple switched interaction regions connected in series for scalable, multiplexed immunoassays. Multiple, switched interaction regions may also be implemented with microvalves.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 26, 2017
    Applicant: HJ Science & Technology, Inc.
    Inventors: Hong Jiao, Erik C. Jensen, Homayun Mehrabani, Liran Yosef Haller
  • Publication number: 20170021352
    Abstract: Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Such systems are suitable for automated microwell plate interfaces.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 26, 2017
    Applicant: HJ SCIENCE & TECHNOLOGY, INC.
    Inventors: Hong Jiao, Erik C Jensen, Homayun Mehrabani, Liran Yosef Haller
  • Publication number: 20170021351
    Abstract: Reconfigurable microfluidic systems are based on networks of microfluidic cavities connected by hydrophobic microfluidic channels. Each cavity is classified as either a reservoir or a node, and includes a pressure port via which gas pressure may be applied. Sequences of gas pressures, applied to reservoirs and nodes according to a fluid transfer rule, enable fluid to be moved from any reservoir to any other reservoir in a system. Such systems are suitable for automated, multi-input, multi-output homogeneous assays.
    Type: Application
    Filed: July 24, 2015
    Publication date: January 26, 2017
    Applicant: HJ Science & Technology, Inc.
    Inventors: Hong Jiao, Erik C. Jensen, Homayun Mehrabani, Liran Yosef Haller
  • Publication number: 20170015746
    Abstract: Aspects of the invention described herein, concern approaches to make genetically modified T-cells comprising a chimeric antigen receptor for human therapy. In some alternatives, the methods utilize a selection and/or isolation of CD4+ and/or CD8+ T-cells from a mixed T-cell population, such as, peripheral blood or apheresis derived mononuclear cells. Once selected/isolated, the CD4+ and/or CD8+ T-cells are then activated, genetically modified, and propagated, preferably, in separate or isolated cultures in the presence of one or more cytokines, which support survival, engraftment and/or proliferation of the cells, as well as, preferably promoting or inducing the retention of cell surface receptors, such as CD62L, CD28, and/or CD27.
    Type: Application
    Filed: April 8, 2015
    Publication date: January 19, 2017
    Applicant: Seattle Children's Hospital (Dba Seattle Children's Research Institute)
    Inventor: Michael C. Jensen
  • Patent number: 9526708
    Abstract: A method of reducing nerve damage associated with prostatectomy in a human subject includes the steps of infiltrating a phenylephrine containing solution into the prostate and/or regions adjacent to the prostate and performing a prostatectomy on the human subject. The methods reduce nerve damage often caused by prostatectomy and thereby increase a subject's odds for recovery of full sexual potency as well as complete continence.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: December 27, 2016
    Inventor: James C. Jensen
  • Publication number: 20160357413
    Abstract: Systems, methods, and devices can allow applications to provide complication data to be displayed in a complication of a watch face. A client application can create a complication data object according to a template to efficiently select how the complication data is to be displayed. For example, a complication controller on the watch can receive new data and determine which template to use. The complication data object can be sent to a display manager that can identify the selected template and display the data according to the template.
    Type: Application
    Filed: September 30, 2015
    Publication date: December 8, 2016
    Inventors: Eliza C. Block, David A. Schimon, Eric Lance Wilson, Joshua H. Shaffer, Paul W. Salzman, Christopher C. Jensen, Timothy C. Lee, Daniel B. Pollack, Alexander Ledwith, Kevin Will Chen, Lawrence Y. Yang, Alan C. Dye
  • Publication number: 20160359666
    Abstract: Messaging between a companion device and an accessory device is controlled such that different modes of communication may be utilized. The different modes can implement different messaging strategies, each of which is intended for efficient power management, in view of the limited electrical power that is typically available at the accessory device. A received request message for sending from the companion device to the accessory device is sent if predetermined conditions apply, and similarly for messages from the accessory device to the companion device.
    Type: Application
    Filed: September 30, 2015
    Publication date: December 8, 2016
    Inventors: Alexander Ledwith, Christopher C. Jensen, John J. Iarocci, Marc J. Krochmal, Ziv Wolkowicki, Daniel B. Pollack, Darin B. Adler
  • Publication number: 20160352839
    Abstract: The described embodiments transfer an activity from a source electronic device to a companion electronic device. The source electronic device receives activity information describing an activity performed in a first application at the source electronic device, determines an activity identifier for the activity information, and broadcasts an activity advertisement comprising the activity identifier. Upon receiving the activity advertisement, the companion electronic device determines whether a second application that is associated with the first application is available at the companion electronic device. Then, the companion electronic device configures the second application and commences performing the activity with the second application at the companion electronic device.
    Type: Application
    Filed: May 25, 2016
    Publication date: December 1, 2016
    Inventors: Christopher S. Linn, Keith Stattenfield, Christopher C. Jensen, Alexander R. Ledwith, David A. Carter, Marc J. Krochmal, John J. Iarocci, Jonathan M. Grynspan
  • Publication number: 20160334386
    Abstract: Described is a personal device and methods for measuring the concentration of an analyte in a sample of gas. The device and method may utilize a chemically selective sensor element with low power consumption integrated with circuitry that enables wireless communication between the sensor and any suitable electronic readout such as a smartphone, tablet, or computer. In preferred form, the sensor circuitry relies upon the quantum capacitance effect of graphene as a transduction mechanism. Also in preferred form, the device and method employ the functionalization of the graphene-based sensor to determine the concentration of nitric oxide in exhaled breath.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 17, 2016
    Inventors: Timothy Clay Anglin, JR., Timothy D. Bemer, Joseph C. Jensen
  • Publication number: 20160333377
    Abstract: Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
    Type: Application
    Filed: May 12, 2016
    Publication date: November 17, 2016
    Inventors: Andrew Scharenberg, David Rawlings, Michael C. Jensen, Kamila Gwiazda, Alexandra Grier
  • Publication number: 20160334388
    Abstract: A basket for use with a fluidics device for simulating in vivo membrane permeation and response is provided. The basket includes an impermeable surface defining a bottom aperture for positioning within the host fluid of the dosing well of the fluidics device. Further, the basket further includes a permeable membrane positioned within the basket and covering the bottom aperture. Additionally, the basket includes a layer covering at least a portion of the membrane covering the bottom aperture for exposing a bottom side of the layer to the host fluid and for preventing an opposing top side of the layer from being exposed to the host fluid. A dose may be placed in contact with the layer for analyzing downstream permeations and responses.
    Type: Application
    Filed: June 15, 2016
    Publication date: November 17, 2016
    Inventors: Randall Edwin McClelland, David J. Sloan, Timothy C. Jensen
  • Publication number: 20160288106
    Abstract: Provided herein are compositions comprising cadmium sulfide quantum dot photocatalysts and methods and systems utilizing as much (e.g., for the reduction of a nitrobenzene to an aniline).
    Type: Application
    Filed: March 18, 2016
    Publication date: October 6, 2016
    Inventors: Stephen C. Jensen, Emily A. Weiss
  • Patent number: 9380123
    Abstract: The described embodiments transfer an activity from a source electronic device to a companion electronic device. The source electronic device receives activity information describing an activity performed in a first application at the source electronic device, determines an activity identifier for the activity information, and broadcasts an activity advertisement comprising the activity identifier. Upon receiving the activity advertisement, the companion electronic device determines whether a second application that is associated with the first application is available at the companion electronic device. If the second application is available, the companion electronic device requests extended activity data from the source electronic device. The source electronic device responds by sending extended activity data from the first application to the companion electronic device.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: June 28, 2016
    Assignee: APPLE INC.
    Inventors: Christopher S. Linn, Keith Stattenfield, Christopher C. Jensen, Alexander R. Ledwith, David A. Carter, Marc J. Krochmal, John J. Iarocci, Jonathan M. Grynspan
  • Publication number: 20160175398
    Abstract: The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 23, 2016
    Inventor: Michael C. Jensen