Patents by Inventor C. Jensen

C. Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210324083
    Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.
    Type: Application
    Filed: August 29, 2019
    Publication date: October 21, 2021
    Inventors: Adam Johnson, Michael C. Jensen
  • Publication number: 20210324407
    Abstract: Some embodiments provided herein relate to gene delivery systems and methods using a single plasmid that carries a self-inactivating transposase gene and a corresponding transposon. Some embodiments include nucleic acids having certain sequences, vector including such nucleic acids, and compositions including the vectors.
    Type: Application
    Filed: August 28, 2019
    Publication date: October 21, 2021
    Inventors: Michael C. Jensen, Joshua Gustafson, Joseph Cheng, Rachel Wilson, Kamila Sabina Gwiazda, Jeremy Bjelajac
  • Publication number: 20210317407
    Abstract: Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
    Type: Application
    Filed: August 2, 2019
    Publication date: October 14, 2021
    Inventors: Michael C. Jensen, James F. Matthaei
  • Publication number: 20210294487
    Abstract: Systems, methods, and devices can allow applications to provide complication data to be displayed in display of an electronic device. A client application can create a data object according to a template to efficiently select how the data object is to be displayed. For example, a complication controller on the electronic device can receive new data and determine which template to use. The data object can be sent to a display manager that can identify the selected template and display the data according to the template.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 23, 2021
    Inventors: Eliza C. Block, David A. Schimon, Eric Lance Wilson, Joshua H. Shaffer, Paul W. Salzman, Christopher C. Jensen, Timothy C. Lee, Daniel B. Pollack, Alexander Ledwith, Kevin Will Chen, Lawrence Y. Yang, Alan C. Dye
  • Patent number: 11123369
    Abstract: Disclosed herein are methods of engineering a bi-specific T-cell expressing chimeric antigen receptors for promoting the in vivo expansion and activation of an effector cell and a second chimeric antigen receptor or TcR specific for a ligand on a tumor. Methods of administering to subjects in need, bi-specific chimeric antigen receptor bearing cells are also provided.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: September 21, 2021
    Assignee: Seattle Children's Hospital
    Inventor: Michael C. Jensen
  • Publication number: 20210269502
    Abstract: The present application relates to fusion proteins, chimeric antigen bearing cells expressing fusion proteins and compositions comprising chimeric antigen bearing cells expressing fusion proteins. The application further relates to methods of using the fusion proteins, cells and compositions for modulating an immune response.
    Type: Application
    Filed: February 2, 2021
    Publication date: September 2, 2021
    Inventors: Michael C. Jensen, Adam Johnson
  • Patent number: 11029831
    Abstract: Systems, methods, and devices can allow applications to provide complication data to be displayed in a complication of a watch face. A client application can create a complication data object according to a template to efficiently select how the complication data is to be displayed. For example, a complication controller on the watch can receive new data and determine which template to use. The complication data object can be sent to a display manager that can identify the selected template and display the data according to the template.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: June 8, 2021
    Assignee: APPLE INC.
    Inventors: Eliza C. Block, David A. Schimon, Eric Lance Wilson, Joshua H. Shaffer, Paul W. Salzman, Christopher C. Jensen, Timothy C. Lee, Daniel B. Pollack, Alexander Ledwith, Kevin Will Chen, Lawrence Y. Yang, Alan C. Dye
  • Patent number: 11023949
    Abstract: A method of fulfilling custom food orders includes obtaining feedback from a user through an ordering application. The feedback relates to a first food item of a first food order following fulfillment of the first food order. The first food item includes a first ingredient. The method includes determining a preferred variation associated with the first ingredient based on the feedback and a first recipe used to make the first food item. The method includes updating a taste profile associated with the user based on the preferred variation. The method includes receiving, from the user, a second food order including a second food item. The method includes retrieving a second recipe associated with the second food item. The method includes selectively modifying the second recipe based on the taste profile. The method includes controlling a food assembly apparatus to prepare the second food item according to the second recipe.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: June 1, 2021
    Assignee: Creator, Inc.
    Inventors: Paul Radcliffe, David Bordow, Jeff C. Jensen, Steven Frehn, Alexandras Vardakostas, John Lawrence McDonald, Harry Shapiro Hawk
  • Publication number: 20210145880
    Abstract: A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
    Type: Application
    Filed: September 22, 2020
    Publication date: May 20, 2021
    Inventors: Yvonne Y. CHEN, Eugenia ZAH, Michael C. JENSEN
  • Publication number: 20210145873
    Abstract: The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific T cells that express a viral antigen T cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting T-cells which express viral antigen. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.
    Type: Application
    Filed: July 2, 2020
    Publication date: May 20, 2021
    Inventors: Laurence J.N. Cooper, Michael C. Jensen
  • Publication number: 20210139583
    Abstract: Aspects of the invention described herein include methods of treating, inhibiting, ameliorating and/or eliminating a virus or cancer cells in a subject utilizing genetically engineered human T-cells having receptors for a molecule presented by the virus or the cancer cells, wherein the genetically engineered T cells are isolated utilizing a two-stage MTX selection that employs increasing concentrations of MTX.
    Type: Application
    Filed: November 12, 2020
    Publication date: May 13, 2021
    Inventors: Michael C. Jensen, Suzie Pun, Nataly Kacherovsky
  • Publication number: 20210103968
    Abstract: A method for fulfilling custom food orders includes: in response to request for a custom food order from a patron through an ordering portal executing on a computing device, retrieving a location of the computing device; identifying a set of food assembly apparatuses within a threshold distance of the location of the computing device; aggregating a list of ingredients currently loaded into the set of food assembly apparatuses; in response to selection of a particular ingredient in the list of ingredients for the custom food order, removing ingredients, from the list of ingredients, unique to a food assembly apparatus not currently loaded with the particular ingredient; selecting a particular food assembly apparatus, from the set, currently loaded with a set of ingredients specified in the custom food order; and inserting the custom food order into a food order queue assigned to the particular food assembly apparatus.
    Type: Application
    Filed: October 19, 2020
    Publication date: April 8, 2021
    Inventors: Steven FREHN, Alexandros VARDAKOSTAS, Jeff C. JENSEN
  • Patent number: 10968431
    Abstract: The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount. The method comprises administering as the CTL preparation a preparation consisting essentially of an in vitro expanded primate CTL population, the CTL population enriched prior to expansion for central memory T lymphocytes, and depleted prior to expansion of effector memory T lymphocytes. In some embodiments, the method may further comprise concurrently administering Interleukin-15 to the subject in an amount effective to increase the proliferation of the central memory T cells in the subject. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: April 6, 2021
    Assignees: City of Hope, Fred Hutchinson Cancer Research Center
    Inventors: Stanley R. Riddell, Susanna Carolina Berger, Michael C. Jensen
  • Publication number: 20210085719
    Abstract: Disclosed herein are methods of engineering a bi-specific T-cell expressing chimeric antigen receptors for promoting the in vivo expansion and activation of an effector cell and a second chimeric antigen receptor or TcR specific for a ligand on a tumor. Methods of administering to subjects in need, bi-specific chimeric antigen receptor bearing cells are also provided.
    Type: Application
    Filed: November 3, 2020
    Publication date: March 25, 2021
    Inventor: Michael C. Jensen
  • Publication number: 20210075122
    Abstract: The techniques described herein relate to a Radio Frequency (RF) communication module for a hand-held mobile electronic device. The Radio Frequency (RF) communication module includes a circuit board and a plurality of antennas disposed on a top side and bottom side of the circuit board. The plurality of antennas comprise a first subset of antennas comprising end-fire antennas and a second subset of antennas comprising broadside antennas. The first subset of antennas and the second subset of antennas also have a bandwidth of approximately 40 percent. The Radio Frequency (RF) communication module also includes a shielded area comprising circuitry coupled to the circuit board for controlling the antennas.
    Type: Application
    Filed: July 20, 2020
    Publication date: March 11, 2021
    Applicant: Intel IP Corporation
    Inventors: Trang Thuy Thai, Sidharth Dalmia, Jonathan C. Jensen, Josef Hagn, Baljit Singh, Bhagyashree S. Ganore, Daniel Roberts Cox, Evan A. Chenelly
  • Publication number: 20210066935
    Abstract: The embodiments set forth a technique for coordinating notifications across computing devices placed onto a wireless charging apparatus. According to some embodiments, the technique can involve the wireless charging apparatus (1) receiving, from a first computing device, first information that includes (i) a first unique identifier (ID) associated with the first computing device, and (ii) one or more unique IDs that are each associated with a respective auxiliary computing device known to the first computing device. Subsequently, the wireless charging apparatus can receive, from a second computing device, second information that at least includes a second unique ID associated with the second computing device. Finally, the wireless charging apparatus can, in response to determining that the second unique ID is included in the one or more unique IDs, and cause both the first and second computing devices to display respective notifications in a coordinated manner.
    Type: Application
    Filed: September 11, 2020
    Publication date: March 4, 2021
    Inventors: Brandon R. GARBUS, Christopher C. JENSEN, Alexei E. KOSUT
  • Publication number: 20210052649
    Abstract: The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In embodiments the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a polynucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. It has been surprisingly found that the length of the spacer region can affects the ability of chimeric receptor modified T cells to recognize target cells in vitro and affects in vivo efficacy of the chimeric receptor modified T cells. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.
    Type: Application
    Filed: September 9, 2020
    Publication date: February 25, 2021
    Inventors: Michael C. Jensen, Stanley R. Riddell, Michael Hudecek
  • Patent number: 10919950
    Abstract: The present application relates to fusion proteins, chimeric antigen bearing cells expressing fusion proteins and compositions comprising chimeric antigen bearing cells expressing fusion proteins. The application further relates to methods of using the fusion proteins, cells and compositions for modulating an immune response.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: February 16, 2021
    Assignee: Seattle Children's Hospital
    Inventors: Michael C. Jensen, Adam Johnson
  • Publication number: 20210040448
    Abstract: Some embodiments provided herein relate to methods and compositions for making genetically modified T cells. In some such embodiments, CD4+ and CD8+ T cells are cultured in a single serum-free volume. In some embodiments, co-cultured CD4+ and CD8+ T cells can be transduced with a lentiviral vector, and a population of transduced T cells can be harvested within a shorter period of time than other conventional methods.
    Type: Application
    Filed: February 4, 2019
    Publication date: February 11, 2021
    Inventors: Michael C. Jensen, Joshua Gustafson
  • Patent number: RE48665
    Abstract: Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains formaldehyde. The technique relies on the use of 2-imidazolidone and a protease enzyme, such as proteinase K, at elevated temperatures. Advantageously, RNA can be isolated and used as a template in nucleic acid amplification reactions.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 3, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Deborah C. Jensen, Brett W. Kirkconnell, Timothy J. Wilson