Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A medical device with closed-loop responsive stimulation may include techniques to mitigate the impact on the therapy output of noise coupled into the medical device. A medical device according to this disclosure may determine the presence of noise and alter the closed loop policy to provide the necessary therapy to the patient and avoid prolonged under stimulation caused by the noise. The medical device may continue therapy, while testing for noise. When the device determines the noise level no longer affects the output therapy, the device may return the closed loop policy to a no-noise mode of operation. The medical device may also include techniques to mitigate the impact of manual adjustment while the medical device is subject to noise or is responding to changes in the patient's physiological signals.

Abstract: Embodiments of the invention include methods and structures for controlling developer critical dimension (DCD) variations across a wafer surface. Aspects of the invention include an apparatus having developer tubing and an internal cam. The internal cam is coupled to a fixed axis. A flexible divider is positioned between the developer tubing and the internal cam. The flexible divider is coupled to the internal cam such that rotation of the internal cam about the fixed axis is operable to change an inner diameter of the developer tubing.

Abstract: A machine learning architecture employs two machine learning networks that are joined by a statistical model allowing the imposition of a predetermined statistical model family into a learning process in which the networks translate between and data types. For example, the statistical model may enforce a Gaussian conditional probability between the latent variables in the translation process. In one application, MRI images may be translated into PET images with reduced mode collapse, blurring, or other “averaging” type behaviors.

Abstract: In an approach, a processor receives device identification information corresponding to at least one device local to a location of a transaction. A processor receives notification of an infected user. A processor determines that the infected user is associated with the transaction. A processor identifies a second user from the device identification information. A processor sends a notification to the second user.

Abstract: A resistor pack assembly including an anti-rotation housing. The anti-rotation housing includes a first surface, a second surface opposite the first surface, one or more anti-rotation lugs extending away from the first surface, and an internal cavity extending from the second surface into the anti-rotation housing towards the first surface. The resistor pack assembly also including a positive rail located at least partially within the internal cavity, a negative rail having an inner circular face and an outer circular face located radially outward from the inner circular face, and an insulator ring is interposed between the second surface of the anti-rotation housing and the outer circular face of the negative rail.

Abstract: Examples of the present disclosure describe implementing bitmap-based data replication when a primary form of data replication between a source device and a target device cannot be used. According to one example, a temporal identifier may be received from the target device. If the source device determines that the primary replication method is unable to be used to replicate data associated with the temporal identifier, a secondary replication method may be initiated. The secondary replication method may utilize a recovery bitmap identifying data blocks that have changed on the source device since a previous event.

Abstract: Technologies for silicon diffraction gratings are disclosed. In some embodiments, grating lines of the diffraction gratings may have several sub-lines that make up each grating line of the diffraction grating. The sub-lines may be sub-wavelength features. In some embodiments, several silicon diffraction gratings may be made from a wafer, such as a wafer with a diameter of 300 millimeters. The wafer may be etched precisely across the entire wafer, leading to a high yield of the diffraction gratings.

Abstract: A control module comprises software instructions for execution by an electronic data processor. An inductance estimator is configured to estimate direct inductance and quadrature inductance associated with the electric machine based on a first set of equations that assume constant rotor resistance and constant magnetic flux. A torque estimator is configured to estimate an observed torque associated with a rotor of the electric machine based a commanded direct-axis voltage and a commanded quadrature-axis voltage, where the observed torque is proportional to the observed power consumption of the electric machine. A pulse-width-modulation (PWM) module is configured to provide pulse-width modulated signals to the electric machine based on the commanded direct-axis voltage and a commanded quadrature-axis voltage. A back-electromotive force adjustment is derived from an estimated, observed torque and a commanded torque.

Abstract: The present disclosure describes methods of preparing carbanucleosides.

Abstract: Method for taking a test using a smartphone including placing the smartphone into connection with a device, placing the device on a head of a person with the smartphone in a position in which a display of the smartphone is visible to the person, coupling the smartphone to the device and displaying test questions on the display. Cheating is detected by, for example, monitoring presence of the device on the head of the person by periodically obtaining biometric data from the person and analyzing a change in the biometric data relative to previously obtained biometric data for the person, and when a change is present, stopping display of the test questions and generating and transmitting a communication to a test-providing institution derived from the change in biometric data.

Abstract: An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

Abstract: A disposable urine trap in the form of a foldable pad that envelops the male genitalia and closes around the organ to form a barrier that prevents urine from escaping the trap. The pad includes an asymmetric pair of wings that are separated by a gap and attached to the main body of the pad. The first wing is preferably trapezoidal and a second wing having an extending distal edge.

Abstract: A system for waterparks or other uses wherein the system combines an electric pump system that can draw water from a lake, a pool or the sea, and pump it through a hose system and sprinklers that can wet objects on or in the water such as a waterpark. It can be connected to floating platforms or other structures that can elevate the sprinklers off the water. The system features an inflatable platform that has an inflatable tower that allows a hose to extend from underwater, through the center of the tower, to a spray nozzle atop the tower that sprays water in any direction. The system can also be attached to any other waterpark structure with various fittings. This will allow a slow drip of water on some items so as to keep them slippery and wet.

Abstract: A coated hybrid electrode for a composite solid-state battery cell is disclosed. Systems and methods are further provided for forming an electrolyte coating including a solid ionically conductive polymer material in the coated hybrid electrode. In one example, the coated hybrid electrode can include an anode material coating, the solid polymer electrolyte coating, and a cathode material coating, such that the solid polymer electrolyte coating can function as a separator coating between the anode material coating and the cathode material coating, thus eliminating a need for a conventional battery separator. In some examples, a slurry-based coating process can be utilized for forming the solid polymer electrolyte coating. As such, the solid polymer electrolyte coating can be mechanically robust with uniform thickness. Further, a battery cell can be formed by utilizing a sub-assembly stacking technique to provide battery cell stiffness and increase precision and accuracy of coating.

Abstract: A method, apparatus, and system according to which a discharge manifold is pressurized by at least a first fracturing pump, said discharge manifold being adapted to communicate pressurized fluid to an oil and gas wellbore.

Abstract: A consumable assembly for supplying filament to a 3D printer includes a spool-less filament coil, a payout tube, and a compressive band. The coil of filament is wound in a configuration having a generally cylindrical outer perimeter and an open interior; the coil has a payout hole extending from an inner layer of the coil to an outer layer of the coil and includes a filament strand configured to be withdrawn through the payout hole in response to a pull force, to thereby withdraw filament from the interior of the coil. The payout tube is disposed in the payout hole and provides a filament port. A compressive band is disposed over the outer layer and is configured to exert a compressive radial force on the coil so that the coil maintains its cylindrical shape without deformation, and the filament strand may be drawn through the filament outlet free of kinks, twists or tangles.

Abstract: A system for error detection m a trading network comprises a memory operable to store a plurality of trader profiles, wherein a particular trader profile is associated with a particular trader. The particular trader profile comprises first contact data associated with a first client device and second contact data associated with a second client device. The memory is further operable to store at least one trading order associated with the particular trader. The system further comprises a processor communicatively coupled to the memory and operable to detect an alert associated with the first client device. In conjunction with detecting the alert, the processor is operable to determine a current status of the at least one trading order and to generate a status message regarding the determined status. The processor is further operable to transmit the status message to the second client device, wherein the transmission is based at least in part on the second contact data.

Abstract: An input shaft includes an annular main shaft extending along a longitudinal axis with an internal bore configured for fluid flow through the annular main shaft. A generator spline is included on an exterior surface of a first end of the main shaft. A gearbox spline is included on an exterior surface of a second end of the main shaft opposite the first end. At least one orifice is defined through the main shaft from the internal bore to the exterior surface of the second end of the main shaft for flow of fluid from the internal bore to the exterior surface for cooling and lubrication.

Abstract: Example high-density cable management bars are provided. In an example, a cable management bar comprises a cable channel configured to fit one or more cables and comprising a first end and a second end. The cable management bar can also comprise a first attachment point extending perpendicular from the first end. The cable management bar can also comprise a second attachment point extending perpendicular from the second end, the first attachment point and the second attachment point configured to attach to a rackmount computer, the cable management system configured to extend away from a rack in which the rackmount computer is located when attached to the rackmount computer via the first attachment point and the second attachment point, and when the rackmount computer is mounted in a rack.