Abstract: An assembly and a method for manufacturing an assembly for transmitting torque to an aircraft actuator. The assembly and method include a torque tube having a longitudinal axis and an end fitting. The ending fitting includes a connector portion and an engagement portion that is inserted into the torque tube. The engagement portion includes a first end adjacent the connector portion, a second end opposite the first end, and a coupling region between the first and second end that includes an outer coupling surface having an outer diameter and a continuous groove formed thereon. The continuous groove includes two axial grooves that extend along the outer coupling surface along the longitudinal axis and a first parallel groove that extends circumferentially about the longitudinal axis along the outer coupling surface that joins the two axial grooves.

Abstract: A container that includes a microwave interactive web at least partially overlying and joined to a three-dimensional support, wherein the three-dimensional support may be formed prior to having the microwave interactive web mounted thereto. The three-dimensional support may be a preformed container that is sufficiently rigid and dimensionally stable for use in containing food.

Abstract: The present invention provides a novel method for preparing a cell-binding agent cytotoxic agent conjugate. The method comprises the step of reacting a cell-binding agent with a cytotoxic agent or a cytotoxic agent-linker compound having a reactive group capable of forming a covalent bond with the cell-binding agent at a pH between 4 to 9 in the presence of a buffer solution with high ionic strength, wherein the cell-binding agent comprises a lysine ?-NH2 group that forms a covalent bond with the cytotoxic agent or the cytotoxic agent-linker compound having an amine-reactive group. The cell-binding agent-cytotoxic agent conjugates prepared according to the methods described herein are also included in the present invention.

Abstract: An assembly and a method for manufacturing an assembly for transmitting torque to an aircraft actuator. The assembly and method include a torque tube having a longitudinal axis and an end fitting. The ending fitting includes a connector portion and an engagement portion that is inserted into the torque tube. The engagement portion includes a first end adjacent the connector portion, a second end opposite the first end, and a coupling region between the first and second end that includes an outer coupling surface having an outer diameter and a continuous groove formed thereon. The continuous groove includes two axial grooves that extend along the outer coupling surface along the longitudinal axis and a first parallel groove that extends circumferentially about the longitudinal axis along the outer coupling surface that joins the two axial grooves.

Abstract: A microwave heating construct comprises a base, a wall extending upwardly around the base for defining a cavity for receiving a food item, and a microwave energy shielding element overlying a lower margin of the wall, the microwave energy shielding element having an upper edge including a substantially incurved portion.

Abstract: This invention relates to antibody-drug conjugates capable of delivering cytotoxic compounds to cancers expressing the guanylyl cyclase C (GCC) transmembrane cell surface receptor.

Abstract: MET is a receptor tyrosine kinase found on the surface of tumor cells. The present invention includes anti-MET antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.

Abstract: The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Abstract: Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1-Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Abstract: A container that includes a microwave interactive web at least partially overlying and joined to a three-dimensional support, wherein the three-dimensional support may be formed prior to having the microwave interactive web mounted thereto. The three-dimensional support may be a preformed container that is sufficiently rigid and dimensionally stable for use in containing food.

Abstract: A method for treating water is provided. The method includes feeding gas through a dielectric barrier discharge (DBD) jet device having an electrode and a ground electrode disposed in water comprising at least one organic toxin derived from a biological organism to generate a cavity in the water, and powering the electrode such that a plasma jet is generated in the cavity. The plasma jet interacts with the water to generate oxidizing agents that oxidize and decompose organic toxins in the water.

Abstract: Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Abstract: A construct for heating a food item in a microwave oven includes a base, a wall extending upwardly from the base, a microwave energy shielding element overlying at least a portion of the wall, and a microwave energy diffusing element circumscribed by the microwave energy shielding element. The microwave energy diffusing element includes a plurality of microwave energy reflective elements within a microwave energy transparent area.

Abstract: The disclosed embodiments relate to a system for identifying entities (such as companies) that are associated with members of an online social network. During operation, the system obtains text strings from member records in the online social network, wherein each text string is an identifier for an entity that is associated with a member. The system also obtains connection information specifying connections among members of the online social network, and possibly location information for the members. Finally, the system uses the text strings, the connection information and the location information to identify entities that are associated with members of the online social network.

Abstract: Dynamically modelling geospatial words in social media, in one aspect, generates a word set based on frequencies of words occurring in GPS annotated text data generated by a GPS-enabled device containing latitude and longitude coordinates. Locations are partitioned by mapping GPS coordinates in the GPS annotated text data to a set of discrete non-overlapped locations. A text stream contained in the GPS annotated text data is segmented into time windows. Footprints of locations in time windows are generated. Geospatial weights associated with words in the word set may be generated based on localness of words determined based on the footprints. Words in a text message are extracted and scores are determined for the set of discrete non-overlapped locations associated with the words.

Abstract: Dynamically modelling geospatial words in social media, in one aspect, generates a word set based on frequencies of words occurring in GPS annotated text data generated by a GPS-enabled device containing latitude and longitude coordinates. Locations are partitioned by mapping GPS coordinates in the GPS annotated text data to a set of discrete non-overlapped locations. A text stream contained in the GPS annotated text data is segmented into time windows. Footprints of locations in time windows are generated. Geospatial weights associated with words in the word set are generated based on localness of words determined based on the footprints. Words in a text message are extracted and scores are determined for the set of discrete non-overlapped locations associated with the words.

Abstract: Dynamically modelling geospatial words in social media, in one aspect, generates a word set based on frequencies of words occurring in GPS annotated text data generated by a GPS-enabled device containing latitude and longitude coordinates. Locations are partitioned by mapping GPS coordinates in the GPS annotated text data to a set of discrete non-overlapped locations. A text stream contained in the GPS annotated text data is segmented into time windows. Footprints of locations in time windows are generated. Geospatial weights associated with words in the word set may be generated based on localness of words determined based on the footprints. Words in a text message are extracted and scores are determined for the set of discrete non-overlapped locations associated with the words.

Abstract: Dynamically modelling geospatial words in social media, in one aspect, generates a word set based on frequencies of words occurring in GPS annotated text data generated by a GPS-enabled device containing latitude and longitude coordinates. Locations are partitioned by mapping GPS coordinates in the GPS annotated text data to a set of discrete non-overlapped locations. A text stream contained in the GPS annotated text data is segmented into time windows. Footprints of locations in time windows are generated. Geospatial weights associated with words in the word set are generated based on localness of words determined based on the footprints. Words in a text message are extracted and scores are determined for the set of discrete non-overlapped locations associated with the words.