Patents by Inventor C. Smith

C. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210246143
    Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 12, 2021
    Inventors: Anna ERICSSON, Neal GREEN, Gary GUSTAFSON, Bingsong HAN, David R. LANCIA, JR., Lorna MITCHELL, David RICHARD, Tatiana SHELEKHIN, Chase C. SMITH, Zhongguo WANG, Xiaozhang ZHENG
  • Patent number: 11083204
    Abstract: A package for raw dough products is disclosed that includes a tray defining an interior storage space, and a collapsible baking pad having an upper surface configured to support a plurality of raw dough products and adapted for movement between a nested condition dimensioned for placement within the interior storage space of the tray for shipping and a flattened condition separated from the tray for baking the raw dough products.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 10, 2021
    Assignee: WESTROCK SHARED SERVICES, LLC
    Inventor: Kenneth C. Smith
  • Publication number: 20210236497
    Abstract: Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.
    Type: Application
    Filed: April 16, 2020
    Publication date: August 5, 2021
    Applicant: OYAGEN, INC.
    Inventors: Harold C. SMITH, Ryan P. BENNETT
  • Publication number: 20210241972
    Abstract: An exemplary system includes a transmitter coil configured to wirelessly transmit a signal to a receiver coil and an electrically conductive shield between the transmitter coil and the receiver coil and connected to an electrical ground. The electrically conductive shield is positioned to shunt electric field energy generated by the transmitter coil to the electrical ground and allow magnetic field energy to pass from the transmitter coil to the receiver coil.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 5, 2021
    Inventors: Marc E. Tognaccini, Douglas C. Smith
  • Publication number: 20210214141
    Abstract: A bag-in-box packaging includes an outer box, a collapsible inner box disposed within an interior of the outer box, and a dispensing tap coupled to the inner bag. The outer box includes a side wall, a tap access feature formed in the side wall, and a removable top wall. The top wall includes overlapping first and second top flaps. The first top flap is hingedly connected to a front side of the side wall along a first tear line. The second top flap is hingedly connected to a rear side of the side wall along a second tear line. The rear side of the side wall is disposed opposite the front side. The top wall is separable from the side wall along the first and second tear lines.
    Type: Application
    Filed: March 26, 2021
    Publication date: July 15, 2021
    Inventor: Kenneth C. SMITH
  • Patent number: 11059823
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: July 13, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Tatiana Koudriakova, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Russell C. Smith, Mark S. Tichenor, Aihua Wang
  • Patent number: 11060409
    Abstract: A turbine blade of ceramic matrix composite material construction adapted for use in a gas turbine engine includes an airfoil assembly. The airfoil assembly includes an airfoil and at least one reinforcement inset coupled to the airfoil assembly. The reinforcement inset is configured to resist damage to the airfoil assembly due to objects impacting the airfoil assembly.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: July 13, 2021
    Inventors: Edward M. Jones, Michael J. Whittle, James C. Smith, Emma C. Steedman, Ian Edmonds
  • Publication number: 20210206768
    Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
    Type: Application
    Filed: March 16, 2021
    Publication date: July 8, 2021
    Inventors: Genesis M. Bacani, Wenying Chai, Tatiana Koudriakova, Paul J. Krawczuk, Kevin D. Kreutter, Kristi Leonard, Michele C. Rizzolio, Mark Seierstad, Russell C. Smith, Mark S. Tichenor, Jennifer D. Venable, Aihua Wang
  • Patent number: 11053142
    Abstract: The exemplary embodiments provides a desalination device comprising an electrochemical cell comprising a porous positive electrode, a porous negative electrode, and a membrane positioned between the porous positive electrode and the porous negative electrode, the electrodes comprising a network of conductive material comprising a plurality of electrode active materials dispersed throughout the conductive material, the porous negative electrode and the porous positive electrode have the same electrode active material, a power supply to supply a current to the electrochemical cell, an inlet for providing a feed stream to the electrochemical cell, a first outlet line for removing a concentrated effluent and a second outlet line for removing a desalinated effluent. Also provided is a desalination device having a plurality of electrochemical channels with alternating anion and cation selective membranes, and a porous negative and positive electrode having the same electrode active material.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: July 6, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Kyle C. Smith, Rylan Doyle Dmello
  • Patent number: 11052393
    Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: July 6, 2021
    Assignee: The General Hospital Corporation
    Inventors: Ravi Kapur, Kyle C. Smith, Mehmet Toner
  • Publication number: 20210198996
    Abstract: A drilling system for drilling a wellbore that includes a drill string rotatable in a first direction. The system also includes a bottom hole assembly (BHA) that includes: a drill bit, a housing with a bore, a first fluid-driven motor in fluid communication with the bore and connected with and configured to rotate a portion of the BHA in a second direction opposite the first direction, a second fluid-driven motor in fluid communication with the bore and connected with and configured to rotate the drill bit, a valve in fluid communication with a vent including a flow path arranged to direct fluid away from any one or both of the fluid-driven motors, and a controller in communication with and configured to adjust a drilling parameter of the BHA by controlling the valve to adjust a flow rate of the fluid output from the valve into the vent.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 1, 2021
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Richard T. Hay, Raymond C. Smith
  • Publication number: 20210190693
    Abstract: An embodiment of a system is described that comprises a light source configured to produce a light beam; a collimating lens disposed on a movable mount, wherein the collimating lens is configured to capture the light beam and produce a substantially collimated beam; and an aspheric diffuse ring optic configured to receive the collimated beam and produce a spot on a surface that comprises a non-uniform radial intensity distribution.
    Type: Application
    Filed: December 17, 2020
    Publication date: June 24, 2021
    Inventor: Malcolm C. Smith
  • Patent number: 11041206
    Abstract: The present invention provides a method of assessing whether an individual is at high risk or low risk of inflammatory bowel disease (IBD) progression by determining the expression level of two or more genes in a whole blood sample. Also provided are methods for treating IBD in an individual who is determined to be at high risk or low risk for IBD progression, and kits for assessing whether an individual is at high risk or low risk for IBD progression. Arrays, and methods of providing arrays, of patient-identified selected gene expression products from a whole blood sample of a patient are also provided.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: June 22, 2021
    Assignee: Cambridge Enterprise Limited
    Inventors: Paul A. Lyons, Kenneth G. C. Smith, Eoin F. McKinney, Daniele Biasci, James Lee
  • Patent number: 11041610
    Abstract: Method and apparatus for a laterally extendable backup light system for placement on the trailer of the 18-wheeler tractor trailer truck device. The light is mounted underneath an outer edge of the trailer of the tractor-trailer so that they would be extendable laterally away from the edge of the trailer so that the light portion of the present invention would extend far enough outwardly to travel beyond the outer edge of the trailer so that the beam of light emanating therefrom would illuminate the area behind the rear of the trailer. An air cylinder operated by an electrical actuator controlled by the driver and/or the transmission of the truck would actuate the light portion so that the light portion would extends from an enclosure and beyond the edge of the trailer of the truck-trailer when the transmission is placed in reverse and then the light portion would be retracted back into the enclosure by an electrical actuator when the transmission is taken out of reverse.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: June 22, 2021
    Inventor: James C. Smith
  • Publication number: 20210182452
    Abstract: Systems and methods for automatically generating cutting lists and panel layouts for roofing projects are disclosed. An exemplary system includes a job management service configured to receive user input for material requirements and store the requirements in a job data file. Prior to processing the requirements, the job management service verifies that a roof data file defines a roof geometry. The job data file and roof data file are moved to an active watch folder, wherein a three-dimensional (3D) roof model is automatically generated by a roof generation engine. The roof generation engine automatically generates cut lists and panel layouts based on mapping the material requirements to the 3D roof model.
    Type: Application
    Filed: December 16, 2019
    Publication date: June 17, 2021
    Applicant: J.R. Systems Pty. Ltd. t/a AppliCad
    Inventor: Raymond C. Smith
  • Publication number: 20210177859
    Abstract: Medicaments for use in treating T-cell acute lymphoblastic leukemia, acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, breast cancer, ovarian cancer, melanoma, lung cancer, pancreatic cancer, glioblastoma, sarcoma, desmoid tumors, adenoid cystic carcinoma, colorectal cancer, head and neck cancer, cervical cancer, prostate cancer, liver cancer, or skin cancer in a patient comprising combination therapy with 4,4,4-trifluoro-N-[(1S)-2-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]butanamide, or a phamlaceutically acceptable salt or hydrate thereof, and 8-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 5, 2017
    Publication date: June 17, 2021
    Applicant: Eli Lilly and Company
    Inventors: Bharvin Kumar PATEL, Michele C. SMITH
  • Publication number: 20210180402
    Abstract: A lock module comprising a housing, a lock pawl, and an actuator. The lock pawl may be moveable between an extended position and a retracted position, wherein the lock pawl extends from the housing by a greater distance in the extended position than in the retracted position. The actuator may be configured to selectively couple to the lock pawl, the lock module being in a locked configuration when the actuator is coupled to the lock pawl. The lock pawl may be configured to move in a first direction as a closure moves from a first position to a second position and the lock pawl may be configured to move in a second direction as the closure moves from the second position to the first position. The first direction may be opposite the second direction. The lock pawl may be configured to block movement of the closure when the lock module is in the locked configuration.
    Type: Application
    Filed: December 15, 2020
    Publication date: June 17, 2021
    Applicant: CornellCookson, LLC
    Inventors: James Janick, Brandon C. Smith, John Bullen
  • Patent number: 11035898
    Abstract: A thermally conductive material, device, and method for predictably maintaining the temperature state and condition of the contact elements and support hardware of a tester interface, such as a probe card, for a testing apparatus, such as automated test equipment (ATE), that has a predetermined configuration applicable for the particular pin contact elements, thermal conditions. The thermally conductive device also has a substrate having a predefined form factor which can be readily introduced into the testing apparatus during normal testing operations. Unlike a patterned substrate that is constrained to specific probe element layouts, the unpatterned surface of the heat conductive device facilitates use with multiple probe card designs within numerous automated test equipment (ATE) tools.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: June 15, 2021
    Assignee: International Test Solutions, Inc.
    Inventors: Alan E. Humphrey, Jerry J. Broz, Wayne C. Smith, Mark M. Stark
  • Patent number: 11032602
    Abstract: Techniques have been developed to facilitate the livestreaming of group audiovisual performances. Audiovisual performances including vocal music are captured and coordinated with performances of other users in ways that can create compelling user and listener experiences. For example, in some cases or embodiments, duets with a host performer may be supported in a sing-with-the-artist style audiovisual livestream in which aspiring vocalists request or queue particular songs for a live radio show entertainment format. The developed techniques provide a communications latency-tolerant mechanism for synchronizing vocal performances captured at geographically-separated devices (e.g., at globally-distributed, but network-connected mobile phones or tablets or at audiovisual capture devices geographically separated from a live studio).
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: June 8, 2021
    Assignee: Smule, Inc.
    Inventors: Anton Holmberg, Benjamin Hersh, Jeannie Yang, Perry R. Cook, Jeffrey C. Smith
  • Patent number: 11031778
    Abstract: In an embodiment, an apparatus includes: a signal pad; a first diode having a first terminal coupled to the signal pad and a second terminal, the first diode having a first polarity; a second diode having a second terminal coupled to the signal pad and a first terminal, the second diode having a second polarity; a first insulated gate bipolar transistor (IGBT) having a first polarity, the first IGBT coupled between the second terminal of the first diode and a reference voltage node; and a second IGBT having the first polarity, the second IGBT coupled between the first terminal of the second diode and the reference voltage node.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: June 8, 2021
    Assignee: Silicon Laboratories Inc.
    Inventor: Jeremy C. Smith