Abstract: A method of forming an imaging fibre apparatus comprises: •arranging core rods 102 and cladding rods 104 to form at least one primary stack 100a, each primary stack 100a comprising a plurality of core rods 102 and cladding rods 104 arranged in a stack arrangement thereby to form a plurality of core regions within a cladding region; •performing a drawing process to form a plurality of drawn stacks from the at least one primary stack; •wherein the plurality of core rods and cladding rods are further arranged to have a selected shape such that the plurality of stacks stack together in a desired arrangement and wherein the stack arrangement comprises an at least partial outer layer of cladding rods thereby to provide separation between core regions of respective adjacent stacks when stacked in the desired arrangement, the method further comprising: •stacking the plurality of drawn stacks together in the desired arrangement to form a further stack; •drawing the further stack; and •using the drawn further stack to

Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: Embodiments of the disclosure include methods and systems for attaching an articulation section. In an embodiment, a medical instrument includes a first tubular member including a first end. The medical instrument also includes a second tubular member including a first end. The second tubular member includes a plurality of layers including an inner layer and a first layer including a fluorinated material. The inner layer includes a first section disposed under the first layer and a second section extending out from under the first layer. A portion of the first tubular member overlaps and is bonded to at least a portion of the second section of the inner layer of the second tubular member.

Abstract: A battery pack can include a plurality of battery cells arranged adjacent one another in a row. The battery pack can include a first spacer plate aligned with and positioned adjacent the first cell of the plurality of battery cells, a second spacer plate aligned with and positioned adjacent the last cell of the plurality of battery cells, and a housing enclosing the plurality of battery cells. The housing can include a first sidewall positioned adjacent the first spacer plate and a second sidewall positioned adjacent the second spacer plate such that the plurality of battery cells can be positioned between the first sidewall and the second sidewall. The battery pack can include a cover. A layer of adhesive can be disposed between the battery cells and the cover. Various techniques can be employed to improve the durability of the battery pack.

Abstract: A battery pack can include a plurality of battery cells arranged adjacent one another in a row. The battery pack can include a first spacer plate aligned with and positioned adjacent the first cell of the plurality of battery cells, a second spacer plate aligned with and positioned adjacent the last cell of the plurality of battery cells, and a housing enclosing the plurality of battery cells. The housing can include a first sidewall positioned adjacent the first spacer plate and a second sidewall positioned adjacent the second spacer plate such that the plurality of battery cells can be positioned between the first sidewall and the second sidewall. The battery pack can include a cover. A layer of adhesive can be disposed between the battery cells and the cover. Various techniques can be employed to improve the durability of the battery pack.

Abstract: A battery pack can include a plurality of battery cells arranged adjacent one another in a row. The battery pack can include a first spacer plate aligned with and positioned adjacent the first cell of the plurality of battery cells, a second spacer plate aligned with and positioned adjacent the last cell of the plurality of battery cells, and a housing enclosing the plurality of battery cells. The housing can include a first sidewall positioned adjacent the first spacer plate and a second sidewall positioned adjacent the second spacer plate such that the plurality of battery cells can be positioned between the first sidewall and the second sidewall. The battery pack can include a cover. A layer of adhesive can be disposed between the battery cells and the cover. Various techniques can be employed to improve the durability of the battery pack.

Abstract: A battery pack includes a housing defining a housing interior, a first stack of electrochemical cells disposed in the housing interior, a second stack of electrochemical cells disposed in the housing interior, and an electronics compartment disposed in the housing interior. The electronics compartment is positioned between the first stack of electrochemical cells and the second stack of electrochemical cells. Further, the electronics compartment extends along a majority of a length of the battery pack.

Abstract: An apparatus includes a thermal actuator switch configured to control a transfer of thermal energy through the thermal actuator switch. The thermal actuator switch includes first and second plates and a piston movable laterally between the first and second plates. The thermal actuator switch also includes a phase change material configured to (i) expand to move a surface of the piston into a first position and (ii) contract to allow the surface of the piston to move into a second position. The surface of the piston thermally contacts the first plate and increases thermal energy transfer between the first and second plates when in one of the first and second positions. The surface of the piston is spaced apart from the first plate and decreases thermal energy transfer between the first and second plates when in another of the first and second positions.

Abstract: A holster for receiving and withdrawing a handgun has a proximal wall portion with a handgun retention mechanism thereon. The mechanism having a first lever with a tab portion for actuation and release of a trigger guard, the lever having a snap fit into a lever region without a separate pin. A belt engaging member covers the lever region capturing the first lever therein. If a second retention mechanism is used, another lever with a tab portion is positioned so the tabs are stacked, depressing one also depresses the tab behind it, such that both mechanisms are released. Overmolded polymer layers in the holster body provides a softer interior handgun engagement surfaces. The holster body is split forwardly with a threaded fastener for clamping onto the handgun. No holster body is beneath or rearward of the tab portion, configured as a thumb button, allowing smooth transition to gripping the handgun.

Abstract: A holster for receiving and withdrawing a handgun has a first handgun retention mechanism. The mechanism having a first lever with a tab portion for actuation and release of a trigger guard, the lever having a snap fit into a lever region without a separate pin. A belt engaging member covers the lever region capturing the first lever therein. If a second retention mechanism is used, another lever with a tab portion is positioned so the tabs are stacked, depressing one also depresses the tab behind it, such that both mechanisms are released. Accessories for the holster or belt engaging members are also provided which include a leg strap adapter that is rotatable and height-adjustable with a leg strap, a red dot sight dust cover that can be incorporated with the holster and a quick detach system that can allow for quick attachment and detachment of a holster.

Abstract: Multichip module thermal management through backside metal systems and methods are disclosed. In one aspect, a multichip module includes one or more flip chip integrated circuits (ICs), each having a backside to which a metal heat conductor or spreader is attached. The presence of the metal heat conductor on the backside of the flip chip ICs allows for a better thermal path to remove heat from the ICs relative to the substrate. The improved thermal path reduces the likelihood of damage to the ICs or delamination of the module. A variety of methods are proposed to construct the backside metal systems. Additionally, a variety of capture features may be used to assist in structural integrity.

Abstract: A holster for receiving and withdrawing a handgun has a proximal wall portion with a handgun retention mechanism thereon. The mechanism having a first lever with a tab portion for actuation and release of a trigger guard, the lever having a snap fit into a lever region without a separate pin. A belt engaging member covers the lever region capturing the first lever therein. If a second retention mechanism is used, another lever with a tab portion is positioned so the tabs are stacked, depressing one also depresses the tab behind it, such that both mechanisms are released. Overmolded polymer layers in the holster body provides a softer interior handgun engagement surfaces. The holster body is split forwardly with a threaded fastener for clamping onto the handgun. No holster body is beneath or rearward of the tab portion, configured as a thumb button, allowing smooth transition to gripping the handgun.

Abstract: A system for determining one or more properties of one or more gases. The system comprises sensors configured to measure thermal conductivity and exothermic responses of a sample at multiple temperatures. Sensor responses to exposure to a gas sample at two or more temperatures are compensated and analyzed by a subsystem. The subsystem is configured to determine a thermal conductivity of the gas sample at each of the two or more temperatures and determine at least one component of the gas sample based at least in part on the thermal conductivity value of the sample at each of the two or more temperatures. Related systems and methods of determining one or more properties of a sample are also disclosed.

Abstract: A system and method for tissue perfusion to assess, maintain, mature, and possibly rehabilitate the tissue. The system of the present teachings includes a tissue enclosure having a fluid reservoir. Pumps, valves, and a controller move perfusate through the tissue. The system includes features to assist in monitoring the health of the tissue, and a removable tray to facilitate moving the tissue from a point of origin to the tissue enclosure. The system moves perfusate to and through the tissue, and provides nutrition to the tissue. The system includes an output flow rate/volume sensor, at least one infusion pump, disposable and durable parts, and a sensor suite.