Abstract: An intervention apparatus is described having a probe with an orifice insertion portion, the insertion portion being configured for insertion into an orifice of a patient. The apparatus also having an intervention tool securement and adjustment mechanism removably attached to the probe. The probe providing support to hold the mechanism in a position relative to the patient, and the adjustment mechanism providing adjustment of an entry point and an angle of entry for an intervention tool to the patient. In embodiments, magnetic resonance imaging, trans-orifice intervention and transperineal intervention are described. Methods for imaging and/or intervention are also described.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port.

Abstract: Disclosed herein is a method for producing an evolvable tissue model of a patient and, using this model, modelling physical transformations of the tissue (e.g. deformation) of the tissue model by interacting the tissue model with influence models which model interactions with the tissue such as surgical instruments, pressure, swelling, temperature changes etc. The model is produced from a set of input data of the tissue which includes directional information of the tissue. The directional information is used to produce an oriented tissue map. A tissue model is then produced from the oriented tissue map such that the tissue model reflects the directionality of the tissue component. When the tissue model is subjected to an influence that causes tissue deformation over a period of time, the tissue model directionally deforms over the period of time in a manner which reflects a trajectory of the influence interacting with the directionality of the tissue component.

Abstract: An intervention apparatus is described having a probe with an orifice insertion portion, the insertion portion being configured for insertion into an orifice of a patient. The apparatus also having an intervention tool securement and adjustment mechanism removably attached to the probe. The probe providing support to hold the mechanism in a position relative to the patient, and the adjustment mechanism providing adjustment of an entry point and an angle of entry for an intervention tool to the patient. In embodiments, magnetic resonance imaging, trans-orifice intervention and transperineal intervention are described. Methods for imaging and/or intervention are also described.

Abstract: Methods and systems for calculating dimensions for fabricating an artificial bone flap. Intra-operative data indicating dimensions of an opening in a portion of the patient's skull are obtained. 3D dimensions of the opening are calculated using the intra-operative data, registered to a reference image. The calculated 3D dimensions are provided for fabricating the artificial bone flap by a fabrication system.

Abstract: An automated positioning device and associated method for use in a medical procedure is provided. The automated positioning device comprises a computing device having a processor coupled to a memory, a multi-joint positioning arm electrically coupled to the computing device and controlled by the computing device, and a sensor module attached to the multi-joint positioning arm and providing a proximity signal to the computing device indicating proximity of a target. The computing device provides a control signal to the multi-joint positioning arm to move the multi-joint positioning arm in response to the proximity signal.

Abstract: A medical navigation system is provided. The medical navigation system includes a computing device having a processor coupled to a memory, a wireless communication component and a display for displaying an image. The medical navigation system further includes a sensor module attached to a medical device. The sensor module includes a housing for housing components of the sensor module and for attaching to the medical device, a processor housed in the housing, a memory coupled to the processor, a wireless communication component coupled to the processor, a battery coupled to the processor, and a sensor coupled to the processor. The sensor generates a signal to be transmitted wirelessly via the sensor module wireless communication component and receivable by the computing device wireless communication component, the signal representing movement of the medical device.

Abstract: Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port.

Abstract: Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.

Abstract: Systems and methods are provided in which devices that are employed during a medical procedure are adaptively configured during the medical procedure, based on input or feedback that is associated with the current state, phase or context of the medical procedure. In some example embodiments, the input is obtained via the identification of one or more medical instruments present within a region of interest, and this input may be employed to determine configuration parameters for configuring the device. In other example embodiments, the input may be based on the image-based detection of a measure associated with the phase or context of the medical procedure, and this input may be employed to adaptively control the device based on the inferred context or phase of the medical procedure. In other embodiments, images from one imaging modality may be employed to adaptively switch to another imaging modality.

Abstract: Systems and methods are provided in which devices that are employed during a medical procedure are adaptively configured during the medical procedure, based on input or feedback that is associated with the current state, phase or context of the medical procedure. In some example embodiments, the input is obtained via the identification of one or more medical instruments present within a region of interest, and this input may be employed to determine configuration parameters for configuring the device. In other example embodiments, the input may be based on the image-based detection of a measure associated with the phase or context of the medical procedure, and this input may be employed to adaptively control the device based on the inferred context or phase of the medical procedure. In other embodiments, images from one imaging modality may be employed to adaptively switch to another imaging modality.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: Systems and methods for rapidly ramping the magnetic field of a superconducting magnet, such as a superconducting magnet adapted for use in a magnetic resonance imaging system, are provided. The magnetic field can be rapidly ramped up or down by changing the current density in the superconducting magnet while monitoring and controlling the superconducting magnet's temperature to remain below a transition temperature. A superconducting switch is used to connect the superconducting magnet and a power supply in a connected circuit. The current generated by the power supply is then adjusted to increase or decrease the current density in the superconducting magnet to respectively ramp up or ramp down the magnetic field strength in a controlled manner. The ramp rate at which the magnetic field strength is changed is determined and optimized based on the operating parameters of the superconducting magnet and the current being generated by the power supply.

Abstract: An automated positioning device and associated method for use in a medical procedure is provided. The automated positioning device comprises a computing device having a processor coupled to a memory, a multi-joint positioning arm electrically coupled to the computing device and controlled by the computing device, and a sensor module attached to the multi-joint positioning arm and providing a proximity signal to the computing device indicating proximity of a target. The computing device provides a control signal to the multi-joint positioning arm to move the multi-joint positioning arm in response to the proximity signal.

Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract: Systems and methods are provided in which local tissue diagnostic measurements are correlated with archival local tissue diagnostic data from prior tissue analyses to supplement diagnostic measurements with tissue analysis data from prior tissue analyses having similar local tissue diagnostic data. The tissue analysis data may include information such as pathology data, outcome data, and diagnosis data. The archived local tissue diagnostic data and the tissue analysis data may be stored in a database, and employed for a wide variety of methods, involving preoperative, intraoperative, and/or postoperative phases of a medical procedure. Methods and systems are also provided for displaying, on a medical image shown in a user interface, hyperlinked reference markers associated with tissue analyses, where the reference markers are shown at locations corresponding to local tissue analyses, and where associated diagnostic data and/or tissue analysis may be viewed by selecting a given reference marker.

Abstract: The present disclosure discloses anatomical phantoms having one or more distinct regions spectroscopically differentiated from each other by inclusion of spectroscopically active components each having a distinct fluorescence/emission/scattering spectrum. The distinct regions may represent different anatomical components of the corresponding real anatomical part and/or tumor mimics (or other diseased tissue) and different anatomical components of the corresponding real anatomical part, or just tumor mimics and a remainder of the anatomical part. The spectroscopically active materials may be dyes such as the cyanine dyes, or spectroscopically active nanoparticles.

Abstract: An electronic device is provided including a processor, an input device coupled to the processor, a memory coupled to the processor; and a module saved in the memory. The module configures the processor to, during a procedure phase of a medical procedure, identify pieces of equipment to be used in the medical procedure using input from the input device; track the pieces of equipment being used in the medical procedure using input from the input device; and account for each of the pieces of equipment at completion of the medical procedure using input from the input device.

Abstract: Methods and systems for providing feedback to guide selection of an artificial bone flap. A user interface for planning a neurosurgical procedure is provided, the neurosurgical procedure including closing of an opening in a portion of a patient's skull using an artificial bone flap. 3D dimensions of the opening are determined using at least pre-operative three-dimensional (3D) imaging data. One or more parameters for selecting an artificial bone flap are determined, where the one or more parameters are based on at least the 3D dimensions of the opening. Output indicating one or more recommended available artificial bone flaps suitable for closing the opening is provided, the recommendation being based on the determined one or more parameters.