Abstract: Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.

Abstract: A system for tracking a piece of medical equipment intraoperatively using a collinear array of fiducial markers positioned at known fixed distances relative to each other on the medical equipment and a camera capturing an image on a single image plane. Representations of the fiducial markers are segmented from a captured image, 3D orientation and position of the medical equipment are calculated using the segmented representations, and the orientation and position of the medical equipment are tracked relative to the camera. The orientation and position of the medical equipment may be registered within a 3D virtual space. The system may be used as part of a surgical navigation system.

Abstract: Systems and methods for co-registering medical images obtained with different imaging modalities are provided. For instance, images obtained with x-ray imaging, such as x-ray computed tomography (“CT”), can be co-registered with images obtained with magnetic resonance imaging (“MRI”). The different imaging modalities generate images that have different visualization characteristics for tissues; thus, in general, co-registration is accomplished by identifying different anatomical features in the different images and then utilizing a known spatial relationship between those anatomical features to co-register the different images.

Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.

Abstract: Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.

Abstract: Systems and methods are provided for transforming a displayed three-dimensional image corresponding to a position and orientation of a field of view of an imaging probe. A three dimensional image of a tissue in a first co-ordinate space can be displayed. A field of view of an imaging probe in a second co-ordinate space can be configured, where the imaging probe has a plurality of transmitters removably connected to it, the transmitters operable to determine the position and orientation of the field of view relative to the positions of the transmitters in the second co-ordinate space. The first and second co-ordinate spaces can be co-registered, and the position and orientation of the field of view in the second co-ordinate space can be transformed to the first co-ordinate space. The three-dimensional image can be displayed to correspond to the transformed position and orientation of the field of view.

Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract: Methods and systems for calculating dimensions for fabricating an artificial bone flap. Intra-operative data indicating dimensions of an opening in a portion of the patient's skull are obtained. 3D dimensions of the opening are calculated using the intra-operative data, registered to a reference image. The calculated 3D dimensions are provided for fabricating the artificial bone flap by a fabrication system.

Abstract: Systems, methods and devices are provided for intraoperatively confirming location of tissue structures during medical procedures. Preoperative image data of a patient's skeletal structure in a vicinity of an anatomical part undergoing a medical procedure is acquired. During the procedure, after exposing tissue intraoperative image data is acquired by scanning a selected region of tissue, in a vicinity of the skeletal structure using Polarization Sensitive-Optical Coherence Tomography (PS-OCT). Regions of tissue exhibiting structural organization in the vicinity of the skeletal structure are identified from the intraoperative (PS-OCT) image data. Geometrically correlating and registering the intraoperative (PS-OCT) image data with the preoperative image data of the skeletal structure in the vicinity of the anatomical part is then performed using a priori known anatomical information about the regions of tissue exhibiting structural information.

Abstract: A brain phantom is disclosed which includes an anatomically correct structure with a life-like sulci outer brain structure. The phantom is made of materials that mimic one or both of biomechanical and imaging properties of the human brain. The phantom may be a single phantom or it may be a kit including a biomechanical phantom and a separate imaging phantom. The imaging phantom includes structures which mimic white brain tracks or bundles which can be observed using DTI, and can include a post production DTI image to allow practitioners to practice imaging techniques on in addition to practicing surgical techniques.

Abstract: A magnetic resonance imaging (MRI) probe includes a coil section having an imaging coil, and a handle section connected to the coil section. The handle section has a phase shifter circuit with inductors, capacitors, and coax line electrically connected and is configured to provide appropriate phase shift. The handle section further has a coaxial cable winding electrically connected to the imaging coil, and wound cylindrically, and has a slot therethrough between the ends of the cylindrical winding. The handle section further has a pre-amp circuit mounted on a substrate and electrically connected to the cylindrical coax winding.

Abstract: System and methods are provided for adaptively and interoperatively configuring an automated arm used during a medical procedure. The automated arm is configured to position and orient an end effector on the automated arm a desired distance and orientation from a target. The end effector may be an external video scope and the target may be a surgical port. The positions and orientations of the end effector and the target may be continuously updated. The position of the arm may be moved to new locations responsive to user commands. The automated arm may include a multi-joint arm attached to a weighted frame. The weighted frame may include a tower and a supporting beam.

Abstract: Systems and methods are provided in which local tissue diagnostic measurements are correlated with archival local tissue diagnostic data from prior tissue analyses to supplement diagnostic measurements with tissue analysis data from prior tissue analyses having similar local tissue diagnostic data. The tissue analysis data may include information such as pathology data, outcome data, and diagnosis data. The archived local tissue diagnostic data and the tissue analysis data may be stored in a database, and employed for a wide variety of methods, involving preoperative, intraoperative, and/or postoperative phases of a medical procedure. Methods and systems are also provided for displaying, on a medical image shown in a user interface, hyperlinked reference markers associated with tissue analyses, where the reference markers are shown at locations corresponding to local tissue analyses, and where associated diagnostic data and/or tissue analysis may be viewed by selecting a given reference marker.

Abstract: Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery.

Abstract: The present invention provides a method and system for identification and isolation of cells from tissues using optical spectroscopy. The method includes accessing the cells using an access corridor, measuring the cells using optical spectroscopy, comparing the spectra of the cells to signature spectra, using the comparison to identify the cells and removing the cells into a container. The system includes an access corridor, a probe for measuring the cells, a resection tool, a collection tube and a collection container.

Abstract: A magnetic resonance imaging (MRI) system is provided. The system includes a main field magnet generating a main magnetic field B0. Moreover, the system further includes radio frequency (RF) receiver coils including a first combination of two coils, the two coils of the first combination decoupled based on quadrature decoupling such that the two coils of the first combination are able to receive signals orthogonal to each other and to B0. The two coils can be butterfly coils, the loop-plain of the butterfly coils arranged along a surface, the longitudinal axis of the butterfly coils being substantially orthogonal and crossing at substantially midpoint. The surface can be substantially orthogonal to B0 and be curved. The first of the two coils can also be a loop coil and the second of the two coils a butterfly coil.

Abstract: Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port.

Abstract: A method of data acquisition at a magnetic resonance imaging (MRI) system is provided. The system receives at least a portion of raw data for an image, and detects anomalies in the portion of raw data received. When anomalies are detected, the system can correct those anomalies dynamically, without waiting for a new scan to be ordered. The system can attempt to scan the offending portion of the raw data, either upon detection of the anomaly or at some point during the scan. The system can also correct anomalies using digital correction methods based on expected values. The anomalies can be detected based on variations from thresholds, masks and expected values all of which can be obtained using one of the ongoing scan, previously performed scans and apriori information relating to the type of scan being performed.