Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: Described is a folding portable luggage scale. The folding portable luggage scale includes multiple folding arms connected via hinges, multiple load sensors, and an electronics housing including electronic components and a digital display. Electrical wires connect each load sensor with the electronics housing. The folding portable luggage scale is compact and lightweight for storage in luggage during travel.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322), the securing device (10) being configured to frictionally maintain its position relative to the objects and to itself, includes a device body (12) having a first end (12A), an opposed second end (12B), and a cross-sectional area. The device body (12) is formed from a material so that the device body (12) exhibits tensile strength of greater than four thousand five hundred kPa and less than nine thousand three hundred kPa. The material that forms the device body (12) has an average coefficient of static friction of greater than 0.75 and less than 1.75 relative to itself. A ratio of the tensile strength (in kPa) to the cross-sectional area (in square millimeters) is greater than 40:1 and less than 100:1. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: Described is a powered massage head. The powered massage includes an exterior portion, an interior portion, a top portion, and a bottom portion. The top portion is formed to contact a portion of a user's body. A motor is housed within the interior portion and a power source within the interior portion is configured for providing power to the motor. A control mechanism within the interior portion controls the motor. The powered massage head may be formed to attached with a massage board for use, or formed to be used independently.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322), the securing device (10) being configured to frictionally maintain its position relative to the objects and to itself, includes a device body (12) having a first end (12A), an opposed second end (12B), and a cross-sectional area. The device body (12) is formed from a material so that the device body (12) exhibits tensile strength of greater than four thousand five hundred kPa and less than nine thousand three hundred kPa. The material that forms the device body (12) has an average coefficient of static friction of greater than 0.75 and less than 1.75 relative to itself. A ratio of the tensile strength (in kPa) to the cross-sectional area (in square millimeters) is greater than 40:1 and less than 100:1. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: The present disclosure describes systems, methods, and non-transitory computer readable media for detecting user interactions to edit a digital image from a client device and modify the digital image for the client device by using a web-based intermediary that modifies a latent vector of the digital image and an image modification neural network to generate a modified digital image from the modified latent vector. In response to user interaction to modify a digital image, for instance, the disclosed systems modify a latent vector extracted from the digital image to reflect the requested modification. The disclosed systems further use a latent vector stream renderer (as an intermediary device) to generate an image delta that indicates a difference between the digital image and the modified digital image. The disclosed systems then provide the image delta as part of a digital stream to a client device to quickly render the modified digital image.

Abstract: Described is a weighing luggage rack having a rack portion with a top section and a bottom section, and a platform portion connected with the top section of the rack portion. In use, the platform portion is stacked on top of the rack portion. The weighing luggage rack further includes a weighing mechanism, and an electronic display configured to display a weight of an object placed thereon. Further embodiments include a weighing luggage rack with only a rack portion and a weighing luggage rack with only a platform portion.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322) includes a device body (12) that is formed from a material so that the device body (12) exhibits elongation of greater than four hundred percent. The material that forms the device body (12) has (i) an average dielectric strength of greater than 200 volts per mil and less than 700 volts per mil at 75 degrees Fahrenheit, and (ii) an average breakdown voltage of greater than 30,000 volts and less than 60,000 volts at 75 degrees Fahrenheit. The device body (12) is also formed from the material so that the device body (12) exhibits a tensile strength of between four thousand five hundred kPa and nine thousand three hundred kPa. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: A securing device (10) for securing a first object (320) relative to a second object (322) includes a device body (12) having a cross-sectional area, and which is formed from a material so that the device body (12) exhibits elongation of between six hundred percent and eight hundred percent. A ratio of the elongation (in percent) to the cross-sectional area (in square millimeters) is between approximately 5:1 and 10:1. The device body (12) is also formed from the material so that the device body (12) exhibits a tensile strength of between four thousand five hundred kPa and nine thousand three hundred kPa. A ratio of the tensile strength (in kPa) to the cross-sectional area (in square millimeters) is between approximately 50:1 and 85:1. The material that forms the device body (12) has an average kinetic coefficient of friction of between approximately 1.35 and 1.60 relative to itself. The material that forms the device body (12) can include thermoplastic elastomers, and can further include styrene.

Abstract: An improved system architecture uses a Generative Adversarial Network (GAN) including a specialized generator neural network to generate multiple resolution output images. The system produces a latent space representation of an input image. The system generates a first output image at a first resolution by providing the latent space representation of the input image as input to a generator neural network comprising an input layer, an output layer, and a plurality of intermediate layers and taking the first output image from an intermediate layer, of the plurality of intermediate layers of the generator neural network. The system generates a second output image at a second resolution different from the first resolution by providing the latent space representation of the input image as input to the generator neural network and taking the second output image from the output layer of the generator neural network.