Patents by Inventor Camilo Colaco

Camilo Colaco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190241923
    Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
    Type: Application
    Filed: February 7, 2019
    Publication date: August 8, 2019
    Inventors: Camilo Colaco, Ian McENTEE
  • Patent number: 10240179
    Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 26, 2019
    Assignee: Immunobiology Limited
    Inventors: Camilo Colaco, Ian McEntee
  • Patent number: 10040820
    Abstract: The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: August 7, 2018
    Assignee: Immunobiology Limited
    Inventors: Camilo Colaco, Colin Richard Bignell
  • Patent number: 9593143
    Abstract: The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.
    Type: Grant
    Filed: September 7, 2009
    Date of Patent: March 14, 2017
    Assignee: IMMUNOBIOLOGY LTD
    Inventors: Camilo Colaco, Kamram Salim
  • Publication number: 20140017274
    Abstract: The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
    Type: Application
    Filed: March 23, 2012
    Publication date: January 16, 2014
    Applicant: Immunobiology Limited
    Inventors: Camilo Colaco, Ian Mcentee
  • Publication number: 20120225067
    Abstract: The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion protein may further comprise a linker sequence or hinge portion which joins the Fc receptor binding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 6, 2012
    Applicant: IMMUNOBIOLOGY LTD
    Inventor: CAMILO COLACO
  • Publication number: 20120135029
    Abstract: The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.
    Type: Application
    Filed: June 21, 2010
    Publication date: May 31, 2012
    Applicant: IMMUNOBIOLOGY LIMITED
    Inventors: Camilo Colaco, Colin Richard Bignell
  • Publication number: 20110206725
    Abstract: The present invention provides a method for the purification of complexes comprising a stress protein complexed to a peptide or peptide fragment, from a source mixture, typically a cell lysate. The improved method of the invention provides for protein complexes to be purified using ion exchange based methods, without the need to use chemicals such as chaotropes and ampholytes. The purified complexes can be used as the immunogenic determinant in vaccine compositions for the treatment or prevention of infectious diseases or cancerous conditions.
    Type: Application
    Filed: September 7, 2009
    Publication date: August 25, 2011
    Applicant: IMMUNOBIOLOGY LIMITED
    Inventors: Camilo Colaco, Kamram Salim
  • Patent number: 7785631
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: August 31, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Patent number: 7780991
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: August 24, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Patent number: 7744925
    Abstract: The present invention encompasses a therapeutic composition in solid dose form that is suitable for pulmonary administration. The therapeutic composition may comprise therapeutic particles in a glassy state. The therapeutic composition preferably comprises a bioactive material such as insulin, and a sugar alcohol. The components are optionally in solid solution. The therapeutic composition can preferably remain in a glassy state when stored at elevated temperatures, and/or extended periods.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: June 29, 2010
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Publication number: 20090186025
    Abstract: The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion peptide may further comprise a linker sequence or hinge portion which joins the Fc receptor biding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.
    Type: Application
    Filed: March 22, 2007
    Publication date: July 23, 2009
    Applicant: ImmunoBiology Limited
    Inventor: Camilo Colaco
  • Publication number: 20080193546
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 14, 2008
    Inventors: Bruce J. ROSER, Jaap KAMPINGA, Camilo COLACO, Julian BLAIR
  • Patent number: 7056495
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 6, 2006
    Assignee: Quadrant Drug Delivery Ltd.
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Publication number: 20050276846
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 15, 2005
    Inventors: Bruce Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Publication number: 20050276845
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 15, 2005
    Inventors: Bruce Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Publication number: 20050276759
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 15, 2005
    Inventors: Bruce Roser, Jaap Kampinga, Camilo Colaco, Julian Blair
  • Publication number: 20050175635
    Abstract: The present invention relates to a method for isolating and identifying specific immunogenic pathogen-specific peptides associated with stress proteins induced by the treatment of pathogens and pathogen-infected cells with stress inducing stimuli. The invention also relates to the use of the antigenic fragments derived from complexes thereof with heat shock or other stresses proteins as the immunogenic determinant in vaccine compositions.
    Type: Application
    Filed: February 22, 2001
    Publication date: August 11, 2005
    Inventor: Camilo Colaco
  • Publication number: 20050163750
    Abstract: The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.
    Type: Application
    Filed: March 18, 2005
    Publication date: July 28, 2005
    Applicant: Elan Drug Delivery Limited
    Inventors: Bruce Roser, Camilo Colaco, Jaap Kampinga, Christopher Smith
  • Patent number: 6893657
    Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: May 17, 2005
    Assignee: Quadrant Drug Delivery Ltd.
    Inventors: Bruce J. Roser, Jaap Kampinga, Camilo Colaco, Julian Blair