Abstract: The present invention relates to compounds: and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

Abstract: The present invention relates to compounds: and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

Abstract: The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.

Abstract: An improved reflective structure utilizing a water transfer printing means for adhesion onto an object in a detachable/non-detachable manner includes a substrate, an isolation layer, an ink layer and a cover layer. The substrate is used for adhesion onto an object, and the isolation layer (an essential oil) is disposed over the substrate and dissolvable in water such that the thickness of the entire structure is reduced. The ink layer has a high polymer content and is printed onto the surface of the isolation layer to provide different patterns. The glass bead layer is capable of reflecting light and is disposed onto the ink layer surface. The cover layer is disposed over the surface of the glass bead layer. Alternatively, the glass bead layer is disposed over the cover layer, and the cover layer is disposed on the ink layer, so that the reflective structure is flexible for complicated, curved shapes.

Abstract: A high reflection ratio material has: a surface layer having a resin layer with an adhesive; a glass bead layer disposed over the surface layer, wherein the glass bead layer having at least one glass beads disposed apart from; the primer layer disposed over the glass bead layer and used for securing the glass beads; the color layer disposed over the primer layer, and the color layer is a printed on the primer layer using a UV OFFSET printing technique; the mirror layer disposed over the color layer and capable of reflecting light to enhance the color layer; and the base disposed over the mirror layer. When a user tears off the surface layer, light shines on the glass bead layer, the light is able to pass through the gap and to sequentially shine and be reflected by the mirror layer, which can increase the brightness.

Abstract: The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to be detected is added onto 5?-terminal of one primer. The asymmetric PCR amplification provided includes the steps: 1) preparative denaturing; 2) repetitiously denaturing, primers annealing, extending cycles as the first stage of PCR amplification; 3) repetitiously denaturing, primer extending cycles as the second stage of PCR amplification, wherein an unrelated nucleic acids sequence to target sequence to be detected is added onto 5?-terminal of one PCR primer of each pair in extension.

Abstract: A heat sink assembly includes a heat sink and a clip. The heat sink includes a base and a plurality of fins extending upwardly from a top surface of the base. The clip includes a pressing body, two bending portions slantwise to the pressing body and extending from two opposite ends of the pressing body, and two locking arms extending from two ends of the bending portions. The pressing body of the clip abuts against the top surface of the base. The bending portions are extended downwardly from the pressing body to be located adjacent to two sides of the base to prevent the clip from moving horizontally along a lateral direction of the heat sink.

Abstract: The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.

Abstract: A heat sink assembly includes a heat sink and a clip. The heat sink includes a base and a plurality of fins extending upwardly from a top surface of the base. The clip includes a pressing body, two bending portions slantwise to the pressing body and extending from two opposite ends of the pressing body, and two locking arms extending from two ends of the bending portions. The pressing body of the clip abuts against the top surface of the base. The bending portions are extended downwardly from the pressing body to be located adjacent to two sides of the base to prevent the clip from moving horizontally along a lateral direction of the heat sink.

Abstract: A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.

Abstract: A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilling is done with a flat bottom, preferably by a two-step drilling process. Then, the end of the capillary can be inserted into the hole so that its end is substantially flush with the flat bottom of the hole, thereby eliminating dead volume. Testing has shown that this connection provides very little band broadening of samples transported through the capillary channel into the capillary tube. The tip of the capillary tube can be tapered, so that it is suitable for use as an electrospray source for a mass spectrometer.