Patents by Inventor Carl A. Alexander

Carl A. Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230095342
    Abstract: In one aspect the invention provides a method of operating a time of flight camera which includes the steps of capturing a sequence of time of flight camera data frames using a set of step frequency modulation signals to provide a time of flight camera data set, then completing a spectral analysis of the dataset which identifies frequency and phase value pairs indicative of the range of the camera to an object represented in the data frames. Next an estimated camera range value to an object represented in the data frames is determined using the frequency value, then a corrected camera range value is determined using the estimated camera range value and the phase value. A camera output is then provided which identifies the corrected range values of at least one object represented in the data frames of the dataset.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 30, 2023
    Applicant: Waikatolink Limited
    Inventors: Carl Alexander LICKFOLD, Lee Vincent STREETER
  • Patent number: 11602543
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: March 14, 2023
    Assignee: A2 Biotherapeutics, Inc.
    Inventors: Carl Alexander Kamb, Dora Toledo Warshaviak, Talar Tokatlian, Agnes Hamburger
  • Patent number: 11602544
    Abstract: The disclosure provides immune cells comprising a first activator receptor and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: March 14, 2023
    Assignee: A2 Biotherapeutics, Inc.
    Inventors: Julyun Oh, Han Xu, Carl Alexander Kamb
  • Publication number: 20230029341
    Abstract: Provided are polynucleotides comprising nucleic acid sequences encoding chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are vectors and immune cells comprising said polynucleotides.
    Type: Application
    Filed: December 11, 2020
    Publication date: January 26, 2023
    Inventors: Carl Alexander Kamb, Agnes E. Hamburger, Breanna Diandreth, Mark E. Daris, Kiran Deshmukh
  • Publication number: 20220389075
    Abstract: Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.
    Type: Application
    Filed: November 10, 2020
    Publication date: December 8, 2022
    Inventors: Julyun OH, Chang Yi, Dora Toledo Warshaviak, Jee Young Mock, Mark Daris, Agnes Hamburger, James Johnston, Carl Alexander Kamb
  • Publication number: 20220370498
    Abstract: The disclosure relates to immune cells for use in adoptive cell therapy that express an inhibitory receptor, useful for treating a disease or disorder, for example, cancer. The disclosure provides immune cells with reduced or eliminated HLA expression, that express an inhibitory receptor, methods of making same, shRNAs targeting HLA-A mRNA, and polynucleotides and vectors encoding same.
    Type: Application
    Filed: April 14, 2022
    Publication date: November 24, 2022
    Inventors: Agnes E. HAMBURGER, Carl Alexander KAMB, Breanna DIANDRETH
  • Publication number: 20220370497
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
    Type: Application
    Filed: May 10, 2022
    Publication date: November 24, 2022
    Inventors: Carl Alexander Kamb, Dora Toledo Warshaviak, Talar Tokatlian, Agnes Hamburger
  • Publication number: 20220339194
    Abstract: The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.
    Type: Application
    Filed: June 28, 2022
    Publication date: October 27, 2022
    Inventors: Yuta Ando, Agnes Hamburger, Jee Young Mock, Julyun OH, Han Xu, Carl Alexander Kamb
  • Patent number: 11481005
    Abstract: In a display assistant device, a speaker is mounted in a waveguide structure which is at least partially disposed beneath a display screen. The waveguide structure is mounted in an exterior housing which includes speaker grills distributed on a plurality of surfaces of the exterior housing, permitting sound waves from the speaker to be projected outside the exterior housing. A cover structure is disposed on top of the waveguide structure to conceal the waveguide structure and speaker within the exterior housing. The cover structure has a tilted bottom surface configured to be suspended above the waveguide structure and to be separated by a first space. Sound waves projected from an upper portion of the speaker are reflected by the tilted bottom surface and are guided through the first space to exit the device from a speaker grill portion located on a rear side of the exterior housing.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: October 25, 2022
    Assignee: Google LLC
    Inventors: James Nelson Castro, Carl Alexander Cepress, Liang Ching Tseng, Darren Torrie, Frances Maria Hui Kwee, Rex Pinegar Price
  • Publication number: 20220315931
    Abstract: The disclosure relates to immune cells for use in adoptive cell therapy useful for treating a disease or disorder, for example, cancer. The disclosure provides immune cells with reduced or eliminated B2M expression, that express an inhibitory receptor, methods of making same, shRNAs targeting B2M mRNA, and polynucleotides and vectors encoding same.
    Type: Application
    Filed: March 28, 2022
    Publication date: October 6, 2022
    Inventors: Agnes E. HAMBURGER, Carl Alexander KAMB, Breanna DIANDRETH
  • Publication number: 20220289818
    Abstract: Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 15, 2022
    Inventors: Carl Alexander Kamb, Agnes E. Hamburger, Breanna Diandreth, Mark E. Daris, Kiran Deshmukh
  • Patent number: 11433100
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to CEA, and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: September 6, 2022
    Assignee: A2 Biotherapeutics, Inc.
    Inventors: Xueyin Wang, Carl Alexander Kamb, Han Xu, Mark L. Sandberg, Dora Toledo Warshaviak
  • Patent number: 11436463
    Abstract: A transaction card is disclosed. The transaction card may include a first card component of non-plastic card material having a thickness of no more than about 0.3 mm, a second card component of composite fiber material having a thickness of no more than about 0.3 mm, and an adhesive for affixing the first layer and second layer together. The non-plastic card material may be selected from a group including wood, bamboo, steel, copper, aluminum, silver, gold, platinum, granite, marble, and slate and the composite fiber material may include at least one of a glass fiber composite, a carbon fiber composite, or a natural fiber composite.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: September 6, 2022
    Assignee: Capital One Services, LLC
    Inventors: Carl Alexander Cepress, Elwin Ching Yee Ong
  • Publication number: 20220273721
    Abstract: The disclosure provides immune cells comprising a first activator receptor and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
    Type: Application
    Filed: May 17, 2022
    Publication date: September 1, 2022
    Inventors: Julyun OH, Han XU, Carl Alexander KAMB
  • Publication number: 20220162287
    Abstract: Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 26, 2022
    Inventors: Carl Alexander KAMB, Agnes E. HAMBURGER, Breanna DIANDRETH, Mark E. DARIS, Kiran DESHMUKH
  • Publication number: 20220153807
    Abstract: Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Inventors: Carl Alexander KAMB, Agnes E. HAMBURGER, Breanna DIANDRETH, Mark E. DARIS, Kiran DESHMUKH
  • Patent number: 11285644
    Abstract: Methods and apparatuses are provided for manufacturing a transaction card. The disclosed methods and apparatuses may be used to form a transaction card frame within a mold. The transaction card frame may include one or more recessed portions formed within a first surface of the transaction card frame. The one or more recessed portions may be configured for affixing one or more electronic components.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: March 29, 2022
    Assignee: Capital One Services, LLC
    Inventors: Carl Alexander Cepress, Elwin Ching Yee Ong
  • Publication number: 20220054551
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to CEA, and a second inhibitory receptor, and methods of making and using same for the treatment of cancer.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Inventors: Xueyin WANG, Carl Alexander KAMB, Han XU, Mark L. SANDBERG, Dora Toledo WARSHAVIAK
  • Patent number: 11254726
    Abstract: Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: February 22, 2022
    Assignee: A2 Biotherapeutics, Inc.
    Inventors: Carl Alexander Kamb, Agnes E. Hamburger, Breanna Diandreth, Mark E. Daris, Kiran Deshmukh
  • Publication number: 20210276234
    Abstract: Methods and apparatuses are provided for manufacturing a transaction card. The disclosed methods and apparatuses may be used to form a transaction card frame within a mold. The transaction card frame may include one or more recessed portions formed within a first surface of the transaction card frame. The one or more recessed portions may be configured for affixing one or more electronic components.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 9, 2021
    Applicant: Capital One Services, LLC
    Inventors: Carl Alexander Cepress, Elwin Ching Yee Ong