Abstract: A vacuum degassing and solvent delivery apparatus for those solvents being utilized in high pressure liquid chromatographic operations and/or applications. The degassing and delivery apparatus of the present invention is designed for attachment directly to a solvent reservoir, such as a bottle having a threaded neck portion. The arrangement facilitates ease of installation and removal of the vacuum degassing, recycling and delivery apparatus so as to accommodate a variety of installation applications and requirements. The solvent degassing system of the present invention further includes the utilization of an atmospheric impermeable composite tubing structure which is effective for isolating fluids from atmospheric contamination during transport.

Abstract: A solvent debubbling/priming device for use in high pressure liquid chromatographic applications includes a valve adapted for releasable and sealed attachment to a bubble collecting/solvent reservoir. The valving portion of the device comprises a valve body with bores formed therein for controlled access and communication between the bubble collecting/solvent reservoir and the exterior of the valve, or atmosphere. The solvent debubbling/priming means includes a length of flexible tubing which has a flattened portion at its distal end and with the tubing being in communication with the bubble collecting/solvent reservoir. The flexible tubing along with its flattened portion provides a flow control and check valve which is chemically inert and free of potentially contaminating lubricants for effective utilization.

Abstract: A flow-through vacuum degassing unit for degassing a liquid includes a vacuum chamber adapted to be connected to a source for creating a vacuum in the chamber, inlet and outlet connections for admitting and discharging liquid to be degassed and one or more tubes for conducting the liquid through the chamber, wherein the tube is formed in a predetermined, memoried configuration and capable of self-supported containment in the vacuum chamber, the tube being of a thin-walled semi-permeable polymeric resin material.

Abstract: A screen printing plate cleaning cabinet comprising walls having an openable portion for placing a screen printing plate in the cabinet. A dispensing subsystem comprises a scanning spray head for discharging cleaning fluid against a screen printing plate and a filter and drain subsystem utilizes pneumatically powered pumps for removing residue and cleaning fluid and pumping the residue and cleaning fluid through filters.

Abstract: An improved solvent handling system for use with a liquid chromatograph is disclosed in which a manifold allows a source of pressurized gas to communicate with a plurality of solvent vessels. Individual check valves prevent return flow into the manifold and cross flow between the solvent vessels. A pressure equalization system is also provided for equalizing the pressure between each solvent vessel and the corresponding supply conduit. An individually manually operated vent is provided for sparging and pressure release.

Abstract: A microprocessor controlled, general purpose gene synthesizer for programmably synthesizing selected nucleotide sequences. Depending upon a programmed chemistry, metered volumes of selected bases and reagent/solvents are sequentially metered into the bottom of a reaction cell containing solid-supported nucleotides, where desired linkages are achieved in an agitated suspension. Self-refilling syringe metering and electrically initiated, pneumatically operated valving insures economical, non-contaminated synthesis. Preprogrammed, selectable chemistries and operator programmed sequences are operatively coupled under microprocessor control to ensure a general purpose synthesizer.

Abstract: A temperature control system for a liquid chromatographic column includes a thin film heater/sensor comprising a foil-like patterned heating element adhesively mounted between a pair of flexible electrically insulative layers. A patterned foil-like temperature sensing element is also coextensively adhesively mounted between the insulative layers in temperature sensing relationship to the heating element. The thin film heater/sensor is wrapped around the chromatographic column and is uniformly compressively secured in contact therewith by a spirally tubularly wound length of flexible wrapping. A remote temperature sensing element controls the heat output of the heating element a linear proportional fashion, thereby maintaining a predetermined temperature gradient over the length of the column. A pre and post-column heaters may be similarly wrapped with a thin film heater/sensors so as to appropriately control the temperature of the liquid entering or leaving the column.