Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A multicore fiber-to-single core fiber adapting device, also referred a fan-in/fan-out (FIFO) device. More specifically, an optical fiber system comprising a multicore fiber, a tapered glass device that it is configured to connect a multicore fiber to a multiple single core fiber, and/or single mode fibers, advantageously having one or more protective layers to protect the tapered device. Associated methods of manufacture.

Abstract: Apparatus and methods for mitigating transverse mode instabilities (TMI) in high power fiber amplifiers that does not depend on active feedback loops. The apparatus and method involve the modulation of the amplitude and/or phase of selected spatial mode components of an input signal beam to increase the TMI threshold of the amplifier. Once the desired modal adjustments are made, the beam is input to a mode multiplexer whereupon an optimized output beam can be input to the active fiber of the amplifier system. By increasing the TMI threshold of the amplifier, the amplifier can be operated at higher power before TMI sets in. A control stage of the fiber amplifier system includes (a) a (seed) beam splitting section; (b) an amplitude and phase control component; and (c) a mode multiplexer that maps multiple individual signal beams to different fiber modes.

Abstract: In one aspect, a temperature sensing assembly for measuring temperature of a surface of a structure includes a thermocouple device and a docking device. The thermocouple device includes a temperature sensing junction point disposed within an elongate sheath to measure the temperature of the surface of the structure at a desired location. The thermocouple device further comprises a contact portion configured to contact the surface of the structure. The docking device has a bottom surface to attach to the surface of the structure adjacent the desired location. A line extends through the center of the sheath and the sheath has a cross-sectional area in a plane perpendicular to the line. The contact portion is configured such that, when the docking device is coupled to the surface, an area of contact between the contact portion and the surface of the structure is greater than the cross-sectional area of the sheath.

Abstract: In one aspect, a temperature sensing assembly for measuring temperature of a surface of a structure includes a thermocouple device and a docking device. The thermocouple device includes a temperature sensing junction point disposed within an elongate sheath to measure the temperature of the surface of the structure at a desired location. The thermocouple device further comprises a contact portion configured to contact the surface of the structure. The docking device has a bottom surface to attach to the surface of the structure adjacent the desired location. A line extends through the center of the sheath and the sheath has a cross-sectional area in a plane perpendicular to the line. The contact portion is configured such that, when the docking device is coupled to the surface, an area of contact between the contact portion and the surface of the structure is greater than the cross-sectional area of the sheath.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A bionanofluid includes a carbon-based nanomaterial substantially mono-dispersed in a fluid. The carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. A hybrid bionanofluid includes the bionanofluid, with the carbon-based nanomaterial further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi-metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product includes the bionanofluid or hybrid bionanofluid. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.

Abstract: A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.

Abstract: A method for boosting the efficiency of chlorine dioxide production in a chemical facility. A chloride donor is introduced into a feed of sulfuric acid or a reducing agent, both of which are injected into the recirculation lines, or other areas, of a chlorine dioxide producing facility. The chloride donor provides the intermediate chemical species necessary for the efficient generation of chlorine dioxide at high acidities and/or the high local acidity in the wake zone of the acid injection location, thereby enabling greater efficiency in the reduction of chlorine dioxide from sodium chlorate.

Abstract: A temperature sensing assembly for measuring the temperature of an inner wall of a high temperature vessel includes a thermocouple assembly having multiple junction points to provide indications of temperature. The assembly further includes support structures for supporting the thermocouple assembly in the interior space of the vessel and to maintain the junction points proximate the inner wall of the vessel.

Abstract: A practical active dressing (PAD) is disclosed that includes a honey-based composition which is to be applied to a patient's wound. Additionally a method of manufacturing a practical active dressing is disclosed. The formulation, with considerable wound and ulcer healing capacity and strong antimicrobial activity, incorporate the combination of active ingredients of ripe honey, gelling agents, plant extracts and chemical compounds.

Abstract: A bionanofluid includes a carbon-based nanomaterial substantially mono-dispersed in a fluid. The carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. A hybrid bionanofluid includes the bionanofluid, with the carbon-based nanomaterial further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi-metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product includes the bionanofluid or hybrid bionanofluid. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.

Abstract: Described are passenger seat assemblies comprising: at least one seat pan; an inflatable seat adjacent to the at least one seat pan; and at least one inflation system comprising a transport device and a delivery mechanism coupled to the transport device, wherein the transport device is configured to inject an inflating substance into the inflatable seat via the delivery mechanism, wherein the delivery mechanism is coupled to the inflatable seat via an opening. The passenger seat assemblies may further comprise a support structure. The inflating substance may be air. The inflatable seat may comprise at least one structural chamber. The inflatable seat may also have utility apart from the passenger seat assembly.

Abstract: A headless suspended mass transfer and reaction tower system used for the scrubbing, stripping or chemical reaction between gases and liquids. The system comprises an elongated shell having a closed top end and a suspension member configured to suspend the tower from an external suspension support. Various embodiments of the system can be adapted for the purposes of chemical vent scrubbing, absorption, odor abatement, gas-liquid chemical reactions, or similar processes. The tower can be operated in the classical counter current or concurrent flow modes, under pressure, or in a partial vacuum.

Abstract: A suspended mass transfer and reaction tower system used for the scrubbing, stripping or chemical reaction between gases and liquids. The system comprises a top head having a suspension means, a bottom head, and a shell capable of retaining and supporting a suspended packing bundle. The shell is capable of securely and removably attaching to the top head and bottom head, thereby creating a single tower capable of being suspended by the suspension means in the top head. Various embodiments of the system can be adapted for the purposes of chemical vent scrubbing, absorption, odor abatement, gas-liquid chemical reactions, or similar processes. The tower can be operated in the classical counter current or concurrent flow modes, under pressure, or in a partial vacuum.

Abstract: Described are passenger seat assemblies comprising: at least one seat pan; an inflatable seat adjacent to the at least one seat pan; and at least one inflation system comprising a transport device and a delivery mechanism coupled to the transport device, wherein the transport device is configured to inject an inflating substance into the inflatable seat via the delivery mechanism, wherein the delivery mechanism is coupled to the inflatable seat via an opening. The passenger seat assemblies may further comprise a support structure. The inflating substance may be air. The inflatable seat may comprise at least one structural chamber. The inflatable seat may also have utility apart from the passenger seat assembly.

Abstract: A headless suspended mass transfer and reaction tower system used for the scrubbing, stripping or chemical reaction between gases and liquids. The system comprises an elongated shell having a closed top end and a suspension member configured to suspend the tower from an external suspension support. Various embodiments of the system can be adapted for the purposes of chemical vent scrubbing, absorption, odor abatement, gas-liquid chemical reactions, or similar processes. The tower can be operated in the classical counter current or concurrent flow modes, under pressure, or in a partial vacuum.